{"id":"https://openalex.org/W7119077064","doi":"https://doi.org/10.1007/s00432-025-06407-3","title":"Harnessing early postoperative MRD and VAF dynamics for precision prognosis in resected colorectal liver metastases","display_name":"Harnessing early postoperative MRD and VAF dynamics for precision prognosis in resected colorectal liver metastases","publication_year":2026,"publication_date":"2026-01-07","ids":{"openalex":"https://openalex.org/W7119077064","doi":"https://doi.org/10.1007/s00432-025-06407-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/41501499"},"language":"en","primary_location":{"id":"doi:10.1007/s00432-025-06407-3","doi":"https://doi.org/10.1007/s00432-025-06407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-025-06407-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-025-06407-3.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s00432-025-06407-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049504343","display_name":"Peisi Li","orcid":"https://orcid.org/0000-0003-0683-2396","observed_orcids":["https://orcid.org/0000-0003-0683-2396"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peisi Li","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046681850","display_name":"T. li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tuoyang Li","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070074072","display_name":"Mingzhe Huang","orcid":"https://orcid.org/0000-0002-8103-9382","observed_orcids":["https://orcid.org/0000-0002-8103-9382"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhe Huang","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-8103-9382","affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070074072","display_name":"Mingzhe Huang","orcid":"https://orcid.org/0000-0002-8103-9382","observed_orcids":["https://orcid.org/0000-0002-8103-9382"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingzhe Huang","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-8103-9382","affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121990538","display_name":"Peiji Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiting Liu","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121990538","display_name":"Peiji Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiji Liu","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120958116","display_name":"Yuanhui Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanhui Wu","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143774386","display_name":"Xuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Li","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066496684","display_name":"Rongzhao He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongzhao He","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001807251","display_name":"Yingguo Gan","orcid":"https://orcid.org/0000-0001-9188-4814","observed_orcids":["https://orcid.org/0000-0001-9188-4814"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingguo Gan","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112912982","display_name":"Yisong Hong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yisong Hong","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133105151","display_name":"Puning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Puning Wang","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. wangpn3@mail.sysu.edu.cn","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. wangpn3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. wangpn3@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100535772","display_name":"Jinxin Lin","orcid":"https://orcid.org/0000-0002-2089-7084","observed_orcids":["https://orcid.org/0000-0002-2089-7084"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinxin Lin","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. linjx69@mail.sysu.edu.cn","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-2089-7084","affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. linjx69@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. linjx69@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077893427","display_name":"Meijin Huang","orcid":"https://orcid.org/0000-0002-1116-0929","observed_orcids":["https://orcid.org/0000-0002-1116-0929"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meijin Huang","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-5483-4591","affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077893427","display_name":"Meijin Huang","orcid":"https://orcid.org/0000-0002-1116-0929","observed_orcids":["https://orcid.org/0000-0002-1116-0929"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210093460","display_name":"Sixth Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/005pe1772","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093460"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meijin Huang","raw_affiliation_strings":["Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-5483-4591","affiliations":[{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, 510655, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China","institution_ids":[]},{"raw_affiliation_string":"Guangdong Institute of Gastroenterology, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancun Erheng Road, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Key Laboratory of Human Microbiome and Chronic Diseases, Sun Yat-Sen University, Ministry of Education, Guangzhou, Guangdong, China. hmjin@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070074072","https://openalex.org/A5077893427","https://openalex.org/A5100535772","https://openalex.org/A5133105151"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210093460"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01388616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"152","issue":"1","first_page":"28","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.5922999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.5922999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.3659999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.9380000233650208},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8519999980926514},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9829999804496765},{"id":"https://openalex.org/keywords/variant-allele-frequency","display_name":"variant allele frequency","score":0.8360000252723694},{"id":"https://openalex.org/keywords/liver-resection","display_name":"hepatectomy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.828000009059906},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7200000286102295},{"id":"https://openalex.org/keywords/adjuvant-treatment-decision-making","display_name":"adjuvant treatment decision-making","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9036999940872192},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.7221999764442444},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6748999953269958},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.6686000227928162},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.604200005531311},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5187000036239624},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.48339998722076416},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C152043487","wikidata":"https://www.wikidata.org/wiki/Q1229600","display_name":"Distributed File System","level":2,"score":0.3474000096321106},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.3352000117301941},{"id":"https://openalex.org/C2777982462","wikidata":"https://www.wikidata.org/wiki/Q2481887","display_name":"Adjuvant therapy","level":3,"score":0.3285999894142151},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32589998841285706},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.31709998846054077},{"id":"https://openalex.org/C2993277928","wikidata":"https://www.wikidata.org/wiki/Q7248370","display_name":"Prognostic model","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2705000042915344},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.2605000138282776},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.2599000036716461}],"mesh":[{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074141","descriptor_name":"Circulating Tumor DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006498","descriptor_name":"Hepatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011184","descriptor_name":"Postoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018365","descriptor_name":"Neoplasm, Residual","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00432-025-06407-3","doi":"https://doi.org/10.1007/s00432-025-06407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-025-06407-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-025-06407-3.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:41501499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41501499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cancer research and clinical oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b729ba47c8b0446795c6e99770390185","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b729ba47c8b0446795c6e99770390185","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cancer Research and Clinical Oncology, Vol 152, Iss 1, Pp 1-11 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12779790","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12779790/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Cancer Res Clin Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00432-025-06407-3","doi":"https://doi.org/10.1007/s00432-025-06407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00432-025-06407-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00432-025-06407-3.pdf","source":{"id":"https://openalex.org/S10075937","display_name":"Journal of Cancer Research and Clinical Oncology","issn_l":"0084-5353","issn":["0084-5353","0171-5216","0301-1585","1432-1335"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cancer Research and Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7583627700805664}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2380222265","display_name":null,"funder_award_id":"82272965","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3196580398","display_name":null,"funder_award_id":"81972245","funder_id":"https://openalex.org/F4320321160","funder_display_name":"Sun Yat-sen University"},{"id":"https://openalex.org/G5320797337","display_name":null,"funder_award_id":"81972245","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5382982982","display_name":null,"funder_award_id":"2022A1515012656","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G5629011502","display_name":null,"funder_award_id":"P20150227202010251","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5884262380","display_name":null,"funder_award_id":"P20150227202010251","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7090465066","display_name":null,"funder_award_id":"81972245","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7107642532","display_name":null,"funder_award_id":"No. 2022A1515012656, HY","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G7572115936","display_name":null,"funder_award_id":"82372715","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G799127221","display_name":null,"funder_award_id":"82173067","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8327317718","display_name":null,"funder_award_id":"No. 82372715, YL; No. 81972245, YL; No. 82173067, YL; No. 82272965, HY","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8637031340","display_name":null,"funder_award_id":"P20150227202010251","funder_id":"https://openalex.org/F4320321160","funder_display_name":"Sun Yat-sen University"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320335785","display_name":"Project 211","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119077064.pdf","grobid_xml":"https://content.openalex.org/works/W7119077064.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W2053351683","https://openalex.org/W2107721849","https://openalex.org/W2142436044","https://openalex.org/W2154018281","https://openalex.org/W2171237493","https://openalex.org/W2262414037","https://openalex.org/W2344528818","https://openalex.org/W2460179076","https://openalex.org/W2751668751","https://openalex.org/W2783686102","https://openalex.org/W2913858058","https://openalex.org/W2978373708","https://openalex.org/W2980567593","https://openalex.org/W3040650012","https://openalex.org/W3120785315","https://openalex.org/W3122882833","https://openalex.org/W3128646645","https://openalex.org/W3130224122","https://openalex.org/W3150444504","https://openalex.org/W3157552357","https://openalex.org/W3159201011","https://openalex.org/W3159598242","https://openalex.org/W3178723556","https://openalex.org/W3184841442","https://openalex.org/W3203274060","https://openalex.org/W3212458558","https://openalex.org/W4285492196","https://openalex.org/W4392365827","https://openalex.org/W4402582106","https://openalex.org/W4403238084","https://openalex.org/W4405310932","https://openalex.org/W4405365503","https://openalex.org/W4406707783","https://openalex.org/W4409889617"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Circulating":[1],"tumor":[2,180],"DNA":[3],"(ctDNA)":[4],"shows":[5],"promise":[6],"for":[7,243],"predicting":[8],"recurrence":[9],"in":[10,33,209,229,260],"colorectal":[11],"cancer":[12],"liver":[13,37,59],"metastases":[14,154],"(CRLM)":[15],"patients.":[16],"We":[17,40],"investigated":[18],"the":[19],"prognostic":[20,207],"value":[21,208],"of":[22,167,227],"perioperative":[23],"ctDNA,":[24],"particularly":[25],"2":[26,56,111,217],"week":[27,112,218],"postoperative":[28,110,140],"minimal":[29],"residual":[30],"disease":[31],"(MRD),":[32],"CRLM":[34,47,231],"patients":[35,48,62,120,130,211,232],"undergoing":[36],"resection.":[38],"METHODS:":[39],"prospectively":[41],"collected":[42],"blood":[43],"samples":[44],"from":[45],"94":[46],"before":[49],"(after":[50],"neoadjuvant":[51],"therapy,":[52],"if":[53],"any)":[54],"and":[55,68,86,152,233,246],"weeks":[57],"after":[58],"metastasectomy.":[60],"63":[61],"had":[63,124],"both":[64],"assessments.":[65],"ctDNA":[66,95,99,219],"status":[67,100,114,221],"variant":[69],"allele":[70],"fraction":[71],"(VAF)":[72],"were":[73,91,164],"determined":[74],"using":[75,83],"targeted":[76],"sequencing.":[77],"Disease-free":[78],"survival":[79],"(DFS)":[80],"was":[81,101,115],"analyzed":[82],"Kaplan-Meier":[84],"curves":[85],"Cox":[87],"regression.":[88],"Baseline":[89],"characteristics":[90],"compared":[92],"based":[93],"on":[94],"status.":[96],"RESULTS:":[97],"Preoperative":[98],"not":[102],"associated":[103],"with":[104,177],"DFS":[105,127,199,228],"(p":[106,134,183,200,212],"=":[107,122,132,144,156,162,184,201,213],"0.77).":[108],"However,":[109],"MRD":[113,141,170,238],"a":[116,173,189,223],"strong":[117],"predictor;":[118],"MRD-positive":[119,210],"(N":[121,131],"31)":[123],"significantly":[125],"worse":[126,198],"than":[128],"MRD-negative":[129,187,261],"32)":[133],"<":[135,150],"0.001).":[136],"In":[137],"multivariate":[138],"analysis,":[139],"positivity":[142,171],"(HR":[143,155],"5.52,":[145],"95%":[146,158],"CI:":[147,159],"2.46-12.39,":[148],"p":[149,161],"0.001)":[151],"multiple":[153],"3.42,":[157],"1.42-8.25,":[160],"0.006)":[163],"independent":[165,225],"predictors":[166],"DFS.":[168],"Postoperative":[169,216],"showed":[172],"trend":[174],"towards":[175],"association":[176],"higher":[178,190],"primary":[179],"T":[181],"stage":[182],"0.095).":[185],"Among":[186],"patients,":[188],"maximum":[191],"absolute":[192],"VAF":[193,253],"change":[194],"(Max\u0394VAF)":[195],"suggested":[196],"potentially":[197],"0.053),":[202],"while":[203],"it":[204],"held":[205],"no":[206],"0.99).":[214],"CONCLUSIONS:":[215],"(MRD)":[220],"is":[222],"potent,":[224],"predictor":[226],"resected":[230],"outperforms":[234],"preoperative":[235],"ctDNA.":[236],"Early":[237],"assessment":[239],"should":[240],"be":[241],"considered":[242],"risk":[244],"stratification":[245],"may":[247],"help":[248],"guide":[249],"adjuvant":[250],"treatment":[251],"decisions.":[252],"dynamics":[254],"might":[255],"further":[256],"refine":[257],"prognosis,":[258],"especially":[259],"cases.":[262]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-01-08T00:00:00"}