{"id":"https://openalex.org/W7119071124","doi":"https://doi.org/10.3390/cancers18020198","title":"L1CAM Promotes Human Endometrial Cancer Via NF-\u03baB Activation","display_name":"L1CAM Promotes Human Endometrial Cancer Via NF-\u03baB Activation","publication_year":2026,"publication_date":"2026-01-08","ids":{"openalex":"https://openalex.org/W7119071124","doi":"https://doi.org/10.3390/cancers18020198","pmid":"https://pubmed.ncbi.nlm.nih.gov/41595121"},"language":"en","primary_location":{"id":"doi:10.3390/cancers18020198","doi":"https://doi.org/10.3390/cancers18020198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18020198","pdf_url":"https://www.mdpi.com/2072-6694/18/2/198/pdf?version=1767856755","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/18/2/198/pdf?version=1767856755","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051868000","display_name":"Hiroyuki Kurosu","orcid":"https://orcid.org/0000-0002-0140-3763","observed_orcids":["https://orcid.org/0000-0002-0140-3763"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kurosu","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan","Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":"https://orcid.org/0000-0002-0140-3763","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088240663","display_name":"Hiroshi Asano","orcid":"https://orcid.org/0000-0002-1033-3920","observed_orcids":["https://orcid.org/0000-0002-1033-3920"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Asano","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1033-3920","affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103594674","display_name":"Salah-eldin Alaa-eldin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86310350","display_name":"Aswan University","ror":"https://ror.org/048qnr849","country_code":"EG","type":"education","lineage":["https://openalex.org/I86310350"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Alaa-eldin Salah-eldin","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Aswan University, Sahary, Aswan P.O. Box 81528, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Aswan University, Sahary, Aswan P.O. Box 81528, Egypt","institution_ids":["https://openalex.org/I86310350"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuya Hamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Hamada","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058285797","display_name":"Shugo Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shugo Tanaka","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112905799","display_name":"Asuka Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asuka Ishii","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005961738","display_name":"Issei Kawakita","orcid":"https://orcid.org/0000-0002-1001-1868","observed_orcids":["https://orcid.org/0000-0002-1001-1868"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Issei Kawakita","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078997926","display_name":"Kentaro Kumagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kentaro Kumagai","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113330217","display_name":"Kensuke Nakazono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kensuke Nakazono","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122263635","display_name":"Yuko Katayama","orcid":"https://orcid.org/0009-0003-1088-5607","observed_orcids":["https://orcid.org/0009-0003-1088-5607"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuko Katayama","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":"https://orcid.org/0009-0003-1088-5607","affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147833403","display_name":"Rino Saito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rino Saito","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120031780","display_name":"Chihiro Terasaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chihiro Terasaka","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102936541","display_name":"Sari Iwasaki","orcid":"https://orcid.org/0000-0002-2075-1122","observed_orcids":["https://orcid.org/0000-0002-2075-1122"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sari Iwasaki","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147846008","display_name":"Satoshi Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Tanaka","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083911091","display_name":"Atsushi Niida","orcid":"https://orcid.org/0000-0002-6851-8004","observed_orcids":["https://orcid.org/0000-0002-6851-8004"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Niida","raw_affiliation_strings":["Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo 106-8639, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo 106-8639, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036752654","display_name":"Hidemichi Watari","orcid":"https://orcid.org/0000-0002-4189-6187","observed_orcids":["https://orcid.org/0000-0002-4189-6187"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidemichi Watari","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009265963","display_name":"Koji Taniguchi","orcid":"https://orcid.org/0000-0002-8091-6005","observed_orcids":["https://orcid.org/0000-0002-8091-6005"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koji Taniguchi","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University,  Sapporo 060-8638,  Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009265963"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":5.4463,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.93157087,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"18","issue":"2","first_page":"198","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.8432999849319458,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l1cam","display_name":"L1CAM","score":0.968999981880188},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5770000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ikk-inhibitor","display_name":"IKK inhibitor","score":0.7889999747276306},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9660000205039978},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.718999981880188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7035999894142151},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6495000123977661},{"id":"https://openalex.org/C206592519","wikidata":"https://www.wikidata.org/wiki/Q1437419","display_name":"L1","level":3,"score":0.646399974822998},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5033000111579895},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4830999970436096},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4708000123500824},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4551999866962433},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.45350000262260437},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4318999946117401},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4318000078201294},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.41909998655319214},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4059999883174896},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.39430001378059387},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.3765999972820282},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.3749000132083893},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3580999970436096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3578999936580658},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.30720001459121704},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2989000082015991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29490000009536743},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.27649998664855957},{"id":"https://openalex.org/C2778515176","wikidata":"https://www.wikidata.org/wiki/Q1209744","display_name":"Uterine cancer","level":3,"score":0.2630999982357025}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cancers18020198","doi":"https://doi.org/10.3390/cancers18020198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18020198","pdf_url":"https://www.mdpi.com/2072-6694/18/2/198/pdf?version=1767856755","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:41595121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41595121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12839394","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12839394/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers (Basel)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/cancers18020198","doi":"https://doi.org/10.3390/cancers18020198","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers18020198","pdf_url":"https://www.mdpi.com/2072-6694/18/2/198/pdf?version=1767856755","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.520211935043335}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1160810528","display_name":null,"funder_award_id":"JPMJSP2119","funder_id":"https://openalex.org/F4320338243","funder_display_name":"JST-Mirai Program"},{"id":"https://openalex.org/G1398243659","display_name":"Study on the role of inflammation in gastrointestinal cancer and regeneration","funder_award_id":"15K21775","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1546158482","display_name":"\u5148\u7aef\u30e2\u30c7\u30eb\u52d5\u7269\u652f\u63f4\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0","funder_award_id":"22H04922","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1752530023","display_name":null,"funder_award_id":"JP20gm6210008","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G2102962636","display_name":"\u8178\u306e\u518d\u751f\u306b\u304a\u3051\u308b\u708e\u75c7\u8a18\u61b6\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e","funder_award_id":"21gm6210008h9904","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G282441840","display_name":null,"funder_award_id":"JP19gm6210008","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G3361386922","display_name":"Platform for Advanced Genome Science","funder_award_id":"16H06279","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G342479731","display_name":"Platform for Advanced Genome Science","funder_award_id":"22H04925","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3453774835","display_name":null,"funder_award_id":"JPMJSP2119","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3501255619","display_name":null,"funder_award_id":"JP MJSP2119","funder_id":"https://openalex.org/F4320323533","funder_display_name":"Hokkaido University"},{"id":"https://openalex.org/G4992230424","display_name":"Development of new gene panel system for molecular classification of endometrial cancer and genetic analysis to search for therapeutic targets","funder_award_id":"24K02581","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5133498890","display_name":null,"funder_award_id":"JP18gm6210008","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G697504518","display_name":null,"funder_award_id":"#JP16H06276","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8250089966","display_name":null,"funder_award_id":"JP16H06276","funder_id":"https://openalex.org/F4320323467","funder_display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research"}],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320309791","display_name":"Suzuken Memorial Foundation","ror":"https://ror.org/03yvcwz92"},{"id":"https://openalex.org/F4320309916","display_name":"Akiyama Life Science Foundation","ror":"https://ror.org/04198sg47"},{"id":"https://openalex.org/F4320310389","display_name":"Novartis Foundation","ror":"https://ror.org/02f9zrr09"},{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320313844","display_name":"Okinaka Memorial Institute for Medical Research","ror":"https://ror.org/03ge26363"},{"id":"https://openalex.org/F4320318912","display_name":"SGH Foundation","ror":"https://ror.org/01tsvpv45"},{"id":"https://openalex.org/F4320322203","display_name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","ror":"https://ror.org/043s0fn12"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320323467","display_name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","ror":"https://ror.org/045p8e908"},{"id":"https://openalex.org/F4320323514","display_name":"Daiichi Sankyo Foundation of Life Science","ror":"https://ror.org/05j492n53"},{"id":"https://openalex.org/F4320323533","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702"},{"id":"https://openalex.org/F4320323572","display_name":"Foundation for Promotion of Cancer Research","ror":"https://ror.org/029aqdy80"},{"id":"https://openalex.org/F4320323961","display_name":"Suhara Memorial Foundation","ror":"https://ror.org/02x0e6v58"},{"id":"https://openalex.org/F4320324271","display_name":"Astellas Foundation for Research on Metabolic Disorders","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320324518","display_name":"Kobayashi Foundation for Cancer Research","ror":"https://ror.org/02qjq5342"},{"id":"https://openalex.org/F4320325287","display_name":"SENSHIN Medical Research Foundation","ror":"https://ror.org/021tj4g88"},{"id":"https://openalex.org/F4320325290","display_name":"Terumo Foundation for Life Sciences and Arts","ror":"https://ror.org/02kbe5v55"},{"id":"https://openalex.org/F4320325293","display_name":"Yasuda Memorial Medical Foundation","ror":"https://ror.org/017cjzj15"},{"id":"https://openalex.org/F4320325449","display_name":"Kanae Foundation for the Promotion of Medical Science","ror":null},{"id":"https://openalex.org/F4320325456","display_name":"Princess Takamatsu Cancer Research Fund","ror":"https://ror.org/00q3q5393"},{"id":"https://openalex.org/F4320325467","display_name":"Waksman Foundation of Japan","ror":"https://ror.org/015qvcc59"},{"id":"https://openalex.org/F4320327417","display_name":"Hitachi Global Foundation","ror":"https://ror.org/02xcybn77"},{"id":"https://openalex.org/F4320331739","display_name":"Toray Science Foundation","ror":"https://ror.org/055mcfk05"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338243","display_name":"JST-Mirai Program","ror":null},{"id":"https://openalex.org/F4320338262","display_name":"Daiichi Sankyo Europe","ror":"https://ror.org/01qhj1g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7119071124.pdf","grobid_xml":"https://content.openalex.org/works/W7119071124.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1532191554","https://openalex.org/W1973223945","https://openalex.org/W1979760206","https://openalex.org/W1998812648","https://openalex.org/W2041440766","https://openalex.org/W2067706102","https://openalex.org/W2080185672","https://openalex.org/W2136865103","https://openalex.org/W2137573595","https://openalex.org/W2157942810","https://openalex.org/W2159722075","https://openalex.org/W2262284635","https://openalex.org/W2511088334","https://openalex.org/W2570729870","https://openalex.org/W2785091318","https://openalex.org/W2793281906","https://openalex.org/W2970591810","https://openalex.org/W2989951595","https://openalex.org/W3017082393","https://openalex.org/W3047152751","https://openalex.org/W3092284014","https://openalex.org/W3114074286","https://openalex.org/W3136632344","https://openalex.org/W3164034212","https://openalex.org/W3164186737","https://openalex.org/W4283014623","https://openalex.org/W4319160026","https://openalex.org/W4378450724","https://openalex.org/W4381309093","https://openalex.org/W4385064156","https://openalex.org/W4392343318","https://openalex.org/W4405916598"],"related_works":[],"abstract_inverted_index":{"Background/Objectives:":[0],"Endometrial":[1],"cancer":[2,61,90,191],"is":[3],"one":[4],"of":[5,56,88,114,121,136,143,194],"the":[6,39,53,86,93,112,126,134,174,195,202],"most":[7],"common":[8],"gynecological":[9],"malignancies,":[10],"with":[11,167],"increasing":[12],"incidence":[13],"and":[14,73,96,110,154,169,185],"mortality":[15],"rates,":[16],"particularly":[17],"in":[18,45,58,160,188,214],"developed":[19],"countries.":[20],"L1":[21],"cell":[22,64,69,71,98],"adhesion":[23],"molecule":[24],"(L1CAM)":[25],"has":[26],"been":[27],"identified":[28],"as":[29,118,138],"a":[30,139,148,207],"poor":[31],"prognostic":[32],"factor":[33],"for":[34,211],"human":[35,59,161,189,216],"endometrial":[36,60,89,190,217],"cancer;":[37],"however,":[38],"molecular":[40],"mechanisms":[41],"underlying":[42],"its":[43],"role":[44,135],"tumor":[46],"progression":[47],"remain":[48],"unclear.":[49],"Methods:":[50],"We":[51],"investigated":[52],"biological":[54],"significance":[55],"L1CAM":[57,79,84,100,131,152,182],"using":[62],"multiple":[63],"lines.":[65],"Functional":[66],"analyses,":[67],"including":[68],"proliferation,":[70],"cycle,":[72],"apoptosis":[74],"assays,":[75],"were":[76],"performed":[77],"after":[78],"knockdown":[80,101],"or":[81],"overexpression.":[82],"Results:":[83],"promoted":[85],"transition":[87],"cells":[91],"from":[92],"G0/G1":[94],"phase":[95],"enhanced":[97,173],"proliferation.":[99],"inhibited":[102],"NF-\u03baB":[103,107,137,156,196],"signaling":[104,197],"by":[105,130],"reducing":[106],"(p65)":[108,157],"phosphorylation":[109],"downregulating":[111],"expression":[113,153],"downstream":[115,141],"targets":[116],"such":[117],"TNF.":[119],"Overexpression":[120],"constitutively":[122],"active":[123],"IKK\u03b2":[124],"restored":[125],"proliferation":[127,184],"defect":[128],"caused":[129],"knockdown,":[132],"supporting":[133],"key":[140],"effector":[142],"L1CAM.":[144],"Immunohistochemical":[145],"analysis":[146],"revealed":[147],"significant":[149],"correlation":[150],"between":[151],"nuclear":[155],"positivity":[158],"rates":[159],"patient":[162],"samples.":[163],"Furthermore,":[164],"combination":[165],"therapy":[166],"cisplatin":[168],"an":[170],"IKK":[171],"inhibitor":[172],"anti-proliferative":[175],"effect.":[176],"Conclusions:":[177],"Our":[178],"study":[179],"demonstrated":[180],"that":[181],"promotes":[183],"chemotherapy":[186],"resistance":[187],"through":[192],"activation":[193],"pathway.":[198],"Therapeutic":[199],"strategies":[200],"targeting":[201],"L1CAM-NF-\u03baB":[203],"pathway":[204],"may":[205],"represent":[206],"promising":[208],"treatment":[209],"option":[210],"improving":[212],"prognosis":[213],"L1CAM-positive":[215],"cancer.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-04T09:36:47.201465","created_date":"2026-01-08T00:00:00"}