{"id":"https://openalex.org/W7119045858","doi":"https://doi.org/10.1186/s12986-025-01064-2","title":"Maternal red blood cell folate metabolites were dynamically associated with neonatal amino acids and acylcarnitines in heel blood: a prospective cohort study","display_name":"Maternal red blood cell folate metabolites were dynamically associated with neonatal amino acids and acylcarnitines in heel blood: a prospective cohort study","publication_year":2026,"publication_date":"2026-01-07","ids":{"openalex":"https://openalex.org/W7119045858","doi":"https://doi.org/10.1186/s12986-025-01064-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/41501784"},"language":"en","primary_location":{"id":"doi:10.1186/s12986-025-01064-2","doi":"https://doi.org/10.1186/s12986-025-01064-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-025-01064-2","pdf_url":null,"source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12986-025-01064-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122243402","display_name":"Ruihua Yang","orcid":"https://orcid.org/0009-0006-5297-0000","observed_orcids":["https://orcid.org/0009-0006-5297-0000"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruihua Yang","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122140970","display_name":"Wei Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zheng","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122032641","display_name":"Yixuan Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Lu","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124115126","display_name":"Yujie Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Zhang","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112618267","display_name":"Lirui Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lirui Zhang","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122045318","display_name":"Xin Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Yan","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028838774","display_name":"Tengda Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengda Chen","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ziyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyu Wang","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123418293","display_name":"Xincong Shi","orcid":"https://orcid.org/0009-0005-6069-8812","observed_orcids":["https://orcid.org/0009-0005-6069-8812"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xincong Shi","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuanyuan Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuanyuan Kong","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China. kongyuanyuan1971@mail.ccmu.edu.cn","Department of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. kongyuanyuan1971@mail.ccmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China. kongyuanyuan1971@mail.ccmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Newborn Screening Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. kongyuanyuan1971@mail.ccmu.edu.cn","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100393103","display_name":"Guanghui Li","orcid":"https://orcid.org/0000-0003-2290-1515","observed_orcids":["https://orcid.org/0000-0003-2290-1515","https://orcid.org/0000-0001-6828-8774"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guanghui Li","raw_affiliation_strings":["Beijing Maternal and Child Health Care Hospital, Beijing, China. liguanghui@ccmu.edu.cn","Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. liguanghui@ccmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Maternal and Child Health Care Hospital, Beijing, China. liguanghui@ccmu.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Department of Nutrition, Endocrinology, and Metabolism, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. liguanghui@ccmu.edu.cn","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100393103"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01213787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"1","first_page":"9","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/red-blood-cell-folate","display_name":"red blood cell folate","score":0.7710000276565552},{"id":"https://openalex.org/keywords/5-methyltetrahydrofolate","display_name":"5-methyltetrahydrofolate","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tetrahydrofolate","display_name":"tetrahydrofolate","score":0.9869999885559082},{"id":"https://openalex.org/keywords/5-formyltetrahydrofolate","display_name":"5-formyltetrahydrofolate","score":0.9890000224113464},{"id":"https://openalex.org/keywords/unmetabolized-folic-acid","display_name":"unmetabolized folic acid","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phenylalanine-and-tyrosine-metabolism","display_name":"phenylalanine and tyrosine metabolism","score":0.8659999966621399},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"urea cycle","score":0.8669999837875366},{"id":"https://openalex.org/keywords/arginine-and-proline-metabolism","display_name":"arginine and proline metabolism","score":0.9409999847412109},{"id":"https://openalex.org/keywords/fatty-acid-beta-oxidation","display_name":"fatty acid beta-oxidation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/prenatal-nutrition","display_name":"prenatal nutrition","score":0.47699999809265137},{"id":"https://openalex.org/keywords/fetal-programming","display_name":"fetal programming","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7052000164985657},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6308000087738037},{"id":"https://openalex.org/C2777248721","wikidata":"https://www.wikidata.org/wiki/Q174647","display_name":"Heel","level":2,"score":0.5605999827384949},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5081999897956848},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4837999939918518},{"id":"https://openalex.org/C148257392","wikidata":"https://www.wikidata.org/wiki/Q2358629","display_name":"Clinical nutrition","level":2,"score":0.4830000102519989},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4657999873161316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45829999446868896},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.41350001096725464},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.39959999918937683},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3946000039577484},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.37689998745918274},{"id":"https://openalex.org/C2994280701","wikidata":"https://www.wikidata.org/wiki/Q4862551","display_name":"Amino acid metabolism","level":3,"score":0.36160001158714294},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.31610000133514404},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C2779750884","wikidata":"https://www.wikidata.org/wiki/Q187706","display_name":"Vitamin B12","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.2915000021457672},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26589998602867126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25519999861717224}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12986-025-01064-2","doi":"https://doi.org/10.1186/s12986-025-01064-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-025-01064-2","pdf_url":null,"source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:41501784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41501784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition & metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:863a2e856e724e6982c1597adeeb2a77","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/863a2e856e724e6982c1597adeeb2a77","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutrition & Metabolism, Vol 23, Iss 1, Pp 1-16 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12809961","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12809961/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nutr Metab (Lond)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12986-025-01064-2","doi":"https://doi.org/10.1186/s12986-025-01064-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12986-025-01064-2","pdf_url":null,"source":{"id":"https://openalex.org/S69338484","display_name":"Nutrition & Metabolism","issn_l":"1743-7075","issn":["1743-7075"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition &amp; Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6735000014305115}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.42648041248321533}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323114","display_name":"Beijing Municipal Health Commission","ror":"https://ror.org/0374a5s68"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W2004168520","https://openalex.org/W2013720766","https://openalex.org/W2054871304","https://openalex.org/W2062118620","https://openalex.org/W2071208072","https://openalex.org/W2095559553","https://openalex.org/W2103538230","https://openalex.org/W2128495572","https://openalex.org/W2147537998","https://openalex.org/W2150910607","https://openalex.org/W2158305865","https://openalex.org/W2293639513","https://openalex.org/W2469250587","https://openalex.org/W2616235706","https://openalex.org/W2618630581","https://openalex.org/W2782624078","https://openalex.org/W2801840020","https://openalex.org/W2804486748","https://openalex.org/W2809192789","https://openalex.org/W2898409819","https://openalex.org/W2899173353","https://openalex.org/W2904375134","https://openalex.org/W2921388099","https://openalex.org/W2979284510","https://openalex.org/W2980645163","https://openalex.org/W2997046468","https://openalex.org/W3022932616","https://openalex.org/W3033727421","https://openalex.org/W3091660427","https://openalex.org/W3128547795","https://openalex.org/W3162156137","https://openalex.org/W3162445641","https://openalex.org/W3165776587","https://openalex.org/W3186795619","https://openalex.org/W3195953296","https://openalex.org/W4206398669","https://openalex.org/W4211032164","https://openalex.org/W4292662648","https://openalex.org/W4293760984","https://openalex.org/W4296614189","https://openalex.org/W4297242717","https://openalex.org/W4319656656","https://openalex.org/W4360612760","https://openalex.org/W4385442153","https://openalex.org/W4385613211","https://openalex.org/W4388422807","https://openalex.org/W4389478096","https://openalex.org/W4389580555","https://openalex.org/W4396219691","https://openalex.org/W4402428461"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Animal":[1],"studies":[2],"indicate":[3],"maternal":[4,120,296,309],"folic":[5,76],"acid":[6,15,77],"intake":[7],"alters":[8],"offspring":[9],"amino":[10],"acids":[11,234,271],"(AAs)":[12],"and":[13,38,53,59,74,86,96,111,129,142,152,173,189,195,199,208,214,225,245,250,257,259,265,279,288,299],"fatty":[14,233,270],"profiles,":[16],"affecting":[17],"their":[18,32,54],"long-term":[19],"health.":[20],"However,":[21],"human":[22],"data":[23],"on":[24],"specific":[25],"folate":[26,58,121,131,172,298,311],"metabolites":[27,61,122],"remain":[28],"limited.":[29],"We":[30,42],"explored":[31],"dynamic":[33],"associations":[34,118,191,317],"with":[35,123,179,185,206,222,227,247,269,306,318],"neonatal":[36,124,180,187,307,319],"AAs":[37,95],"acylcarnitines":[39],"(ACs).":[40],"METHODS:":[41],"conducted":[43],"a":[44,156],"prospective":[45],"cohort":[46],"study,":[47],"involving":[48],"4130":[49],"singleton":[50],"pregnant":[51],"women":[52],"neonates.":[55],"Maternal":[56],"total":[57,130,297],"related":[60,242,282],"in":[62,81,193,197,202,211,231,237,253,274,292],"red":[63],"blood":[64,107],"cell":[65],"(RBC),":[66],"including":[67,93],"5-methyltetrahydrofolate":[68],"(5-MTHF),":[69],"tetrahydrofolate":[70],"(THF),":[71],"5-formyltetrahydrofolate":[72],"(5-CHO-THF),":[73],"unmetabolized":[75],"(UMFA),":[78],"were":[79,99,114,183],"measured":[80],"6-17":[82],"(T1),":[83],"20-26":[84],"(T2),":[85],"32-36":[87],"(T3)":[88],"gestational":[89],"weeks.":[90],"Neonatal":[91],"metabolites,":[92,188,308,312],"11":[94],"31":[97],"ACs,":[98,229],"routinely":[100],"tested":[101],"72":[102],"h":[103],"postpartum":[104],"using":[105],"heel":[106],"samples.":[108],"Linear":[109],"regression":[110],"pathway":[112],"analysis":[113],"used":[115],"to":[116,137,146,243,283],"evaluate":[117],"between":[119],"metabolic":[125,320],"pathways.":[126],"RESULTS:":[127],"5-MTHF":[128,174,300],"levels":[132,154,301],"significantly":[133],"increased":[134],"from":[135,144],"T1":[136,194,203],"T2":[138,145,198,238],"(p":[139,148,160,168],"<":[140,161,169],"0.001),":[141],"stabilized":[143],"T3":[147,240],">":[149],"0.05).":[150],"THF":[151,182,201,236],"5-CHO-THF":[153,262],"showed":[155,175,302],"continuous":[157],"upward":[158],"trend":[159],"0.001).":[162,170],"Conversely,":[163],"UMFA":[164,276],"declined":[165,196],"throughout":[166],"pregnancy":[167],"Total":[171],"no":[176,303],"significant":[177,304],"correlations":[178],"metabolism.":[181,216,261],"associated":[184,221],"multiple":[186],"the":[190,212,232,254,284],"peaked":[192],"T3.":[200],"positively":[204,220,241],"correlated":[205,268],"phenylalanine":[207,213],"tyrosine,":[209],"involved":[210,230,252],"tyrosine":[215],"And":[217],"it":[218],"was":[219],"7":[223],"ACs":[224],"negatively":[226,246],"9":[228],"\u03b2-oxidation.":[235],"or":[239],"arginine,":[244],"citrulline,":[248],"glycine,":[249],"ornithine,":[251],"urea":[255,285],"cycle":[256],"arginine":[258,287],"proline":[260,289],"displayed":[263],"similar":[264],"weaker":[266,280],"impacts,":[267],"\u03b2-oxidation":[272],"only":[273,291],"T1.":[275,293],"exhibited":[277,315],"different":[278],"influence,":[281],"cycle,":[286],"metabolism":[290],"CONCLUSIONS:":[294],"Although":[295],"association":[305],"certain":[310],"especially":[313],"THF,":[314],"trimester-specific":[316],"pathways,":[321],"warranting":[322],"clinical":[323],"attention.":[324]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-01-08T00:00:00"}
