{"id":"https://openalex.org/W7119002087","doi":"https://doi.org/10.1186/s13068-025-02729-z","title":"Characterization of strain degeneration in the RL-P37 strain lineage of Trichoderma reesei","display_name":"Characterization of strain degeneration in the RL-P37 strain lineage of Trichoderma reesei","publication_year":2026,"publication_date":"2026-01-06","ids":{"openalex":"https://openalex.org/W7119002087","doi":"https://doi.org/10.1186/s13068-025-02729-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41495811"},"language":"en","primary_location":{"id":"doi:10.1186/s13068-025-02729-z","doi":"https://doi.org/10.1186/s13068-025-02729-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13068-025-02729-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210233465","display_name":"Biotechnology for Biofuels and Bioproducts","issn_l":"2731-3654","issn":["2731-3654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-2","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology for Biofuels and Bioproducts","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13068-025-02729-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008962786","display_name":"Caroline Danner","orcid":"https://orcid.org/0000-0001-7212-828X","observed_orcids":["https://orcid.org/0000-0001-7212-828X"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Caroline Danner","raw_affiliation_strings":["Christian Doppler Laboratory for Optimized Expression of Carbohydrate-Active Enzymes, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Optimized Expression of Carbohydrate-Active Enzymes, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122165252","display_name":"Armin Gabriel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Armin Gabriel","raw_affiliation_strings":["Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067767356","display_name":"Christian Zimmermann","orcid":"https://orcid.org/0000-0002-6440-2100","observed_orcids":["https://orcid.org/0000-0002-6440-2100"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christian Zimmermann","raw_affiliation_strings":["Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024407452","display_name":"Robert Ludwig Mach","orcid":"https://orcid.org/0000-0003-2375-7244","observed_orcids":["https://orcid.org/0000-0003-2375-7244"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Robert L. Mach","raw_affiliation_strings":["Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuriy Karpenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Yuriy Karpenko","raw_affiliation_strings":["Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076586919","display_name":"Igor Nikolaev","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Nikolaev","raw_affiliation_strings":["IFF Health & Biosciences, Willem Einthovenstraat 4, 2342BH, Oegstgeest, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IFF Health & Biosciences, Willem Einthovenstraat 4, 2342BH, Oegstgeest, Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040171871","display_name":"Sharief Barends","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharief Barends","raw_affiliation_strings":["IFF Health & Biosciences, Willem Einthovenstraat 4, 2342BH, Oegstgeest, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IFF Health & Biosciences, Willem Einthovenstraat 4, 2342BH, Oegstgeest, Netherlands","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049196128","display_name":"Astrid Rosa Mach-Aigner","orcid":"https://orcid.org/0000-0002-7575-2317","observed_orcids":["https://orcid.org/0000-0002-7575-2317"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Astrid R. Mach-Aigner","raw_affiliation_strings":["Christian Doppler Laboratory for Optimized Expression of Carbohydrate-Active Enzymes, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria. astrid.mach-aigner@tuwien.ac.at","Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria. astrid.mach-aigner@tuwien.ac.at"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Optimized Expression of Carbohydrate-Active Enzymes, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria. astrid.mach-aigner@tuwien.ac.at","institution_ids":["https://openalex.org/I145847075"]},{"raw_affiliation_string":"Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Str. 1a, 1060, Vienna, Austria. astrid.mach-aigner@tuwien.ac.at","institution_ids":["https://openalex.org/I145847075"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049196128"],"corresponding_institution_ids":["https://openalex.org/I145847075"],"apc_list":{"value":1990,"currency":"GBP","value_usd":2440},"apc_paid":{"value":1990,"currency":"GBP","value_usd":2440},"fwci":1.789,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.77224731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"19","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.5746999979019165,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.22200000286102295,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.17870000004768372,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trichoderma-reesei","display_name":"Trichoderma reesei","score":0.953000009059906},{"id":"https://openalex.org/keywords/strain-degeneration","display_name":"strain degeneration","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hyphal-morphology","display_name":"hyphal morphology","score":0.9139999747276306},{"id":"https://openalex.org/keywords/filamentous-fungi","display_name":"filamentous fungi","score":0.6769999861717224},{"id":"https://openalex.org/keywords/strain-monitoring","display_name":"strain monitoring","score":0.5410000085830688},{"id":"https://openalex.org/keywords/cellulase-production","display_name":"cellulase production","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C141603559","wikidata":"https://www.wikidata.org/wiki/Q410324","display_name":"Cellulase","level":3,"score":0.9401000142097473},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.7766000032424927},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.6780999898910522},{"id":"https://openalex.org/C2776125036","wikidata":"https://www.wikidata.org/wiki/Q2749932","display_name":"Trichoderma reesei","level":4,"score":0.6500999927520752},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6234999895095825},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.6122000217437744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6057000160217285},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5210000276565552},{"id":"https://openalex.org/C2908559767","wikidata":"https://www.wikidata.org/wiki/Q159341","display_name":"Filamentous fungus","level":3,"score":0.5203999876976013},{"id":"https://openalex.org/C2779678110","wikidata":"https://www.wikidata.org/wiki/Q764","display_name":"Fungus","level":2,"score":0.3898000121116638},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34049999713897705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2948000133037567},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.26089999079704285},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2533000111579895},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s13068-025-02729-z","doi":"https://doi.org/10.1186/s13068-025-02729-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13068-025-02729-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210233465","display_name":"Biotechnology for Biofuels and Bioproducts","issn_l":"2731-3654","issn":["2731-3654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-2","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology for Biofuels and Bioproducts","raw_type":"journal-article"},{"id":"pmid:41495811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41495811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology for biofuels and bioproducts","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11659095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12853576","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:23f9edc29d4746088c2d70543137c6e1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/23f9edc29d4746088c2d70543137c6e1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biotechnology for Biofuels and Bioproducts, Vol 19, Iss 1, Pp 1-14 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12853576","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12853576/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biotechnol Biofuels Bioprod","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s13068-025-02729-z","doi":"https://doi.org/10.1186/s13068-025-02729-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13068-025-02729-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210233465","display_name":"Biotechnology for Biofuels and Bioproducts","issn_l":"2731-3654","issn":["2731-3654"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-2","norway-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology for Biofuels and Bioproducts","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Industry, innovation and infrastructure","score":0.5884042978286743,"id":"https://metadata.un.org/sdg/9"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323591","display_name":"Christian Doppler Forschungsgesellschaft","ror":"https://ror.org/00mv8h305"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W21840422","https://openalex.org/W1725994061","https://openalex.org/W1971597295","https://openalex.org/W2019462270","https://openalex.org/W2032967267","https://openalex.org/W2056561062","https://openalex.org/W2063838036","https://openalex.org/W2071492220","https://openalex.org/W2086907581","https://openalex.org/W2095065963","https://openalex.org/W2096947765","https://openalex.org/W2118829612","https://openalex.org/W2121244715","https://openalex.org/W2127297472","https://openalex.org/W2315069336","https://openalex.org/W2409267134","https://openalex.org/W2494850533","https://openalex.org/W2508906503","https://openalex.org/W2527739344","https://openalex.org/W2618962964","https://openalex.org/W2788004430","https://openalex.org/W3028872426","https://openalex.org/W3127690937","https://openalex.org/W3131375864","https://openalex.org/W3201666303","https://openalex.org/W3202484899","https://openalex.org/W4220826627","https://openalex.org/W4224849971","https://openalex.org/W4381470547","https://openalex.org/W4390346331","https://openalex.org/W4400112399","https://openalex.org/W4408155600"],"related_works":[],"abstract_inverted_index":{"Spontaneous":[0],"strain":[1,68,148,180],"degeneration,":[2,170],"defined":[3],"as":[4,174],"the":[5,26,62,94,98,154],"loss":[6,42],"of":[7,43,75],"an":[8],"essential":[9],"biological":[10],"function":[11],"during":[12],"prolonged":[13],"usage,":[14],"is":[15],"frequently":[16],"observed":[17],"in":[18,70,138,150],"microorganisms":[19],"and":[20,79,88,117,158,160,169],"poses":[21],"a":[22,32,71,144],"significant":[23],"challenge":[24],"to":[25,166],"biotechnology":[27],"industry.":[28],"In":[29,121],"Trichoderma":[30],"reesei,":[31,77,152],"filamentous":[33],"fungus":[34],"widely":[35],"used":[36],"for":[37,146,178],"large-scale":[38],"cellulase":[39,44,112,123,167],"production,":[40],"spontaneous":[41],"productivity":[45,157],"has":[46],"been":[47],"reported.":[48],"However,":[49],"studies":[50],"on":[51,57],"this":[52],"phenomenon":[53],"have":[54],"focused":[55],"solely":[56],"industrial":[58,73,179],"strains":[59],"derived":[60],"from":[61],"Rut-C30":[63],"lineage.":[64],"This":[65],"study":[66,142],"analyzes":[67],"degeneration":[69,95,149],"different":[72],"lineage":[74],"T.":[76,151],"RL-P37,":[78],"its":[80],"hypercellulase-producing":[81],"descendant,":[82],"GEN-3A.":[83],"We":[84],"found":[85],"that":[86],"RL-P37":[87],"GEN-3A":[89,101],"are":[90],"also":[91],"affected":[92],"by":[93,110],"phenomenon,":[96],"with":[97,127],"highly":[99,129],"productive":[100],"showing":[102],"greater":[103],"susceptibility.":[104],"The":[105],"degenerated":[106,139],"phenotype":[107],"was":[108,125],"characterized":[109],"reduced":[111],"productivity,":[113],"altered":[114],"growth":[115],"behavior,":[116],"distinct":[118],"morphological":[119,134,163],"changes.":[120],"particular,":[122],"hyperproduction":[124,168],"associated":[126],"bulbous,":[128],"branched":[130],"hyphae,":[131],"while":[132],"these":[133],"traits":[135],"were":[136],"lost":[137],"isolates.":[140],"Our":[141],"establishes":[143],"framework":[145],"characterizing":[147],"highlights":[153],"trade-off":[155],"between":[156],"stability,":[159],"identifies":[161],"distinctive":[162],"signatures":[164],"linked":[165],"which":[171],"may":[172],"serve":[173],"early":[175],"phenotypic":[176],"indicators":[177],"monitoring.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-01-08T00:00:00"}
