{"id":"https://openalex.org/W7118724916","doi":"https://doi.org/10.1111/all.70209","title":"Single\u2010Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations","display_name":"Single\u2010Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations","publication_year":2026,"publication_date":"2026-01-07","ids":{"openalex":"https://openalex.org/W7118724916","doi":"https://doi.org/10.1111/all.70209","pmid":"https://pubmed.ncbi.nlm.nih.gov/41498390"},"language":"en","primary_location":{"id":"doi:10.1111/all.70209","doi":"https://doi.org/10.1111/all.70209","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.70209","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.70209","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.70209","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079544024","display_name":"Sofia Papavasileiou","orcid":"https://orcid.org/0000-0002-4066-5715","observed_orcids":["https://orcid.org/0000-0002-4066-5715"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Sofia Papavasileiou","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0002-4066-5715","affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002956847","display_name":"Jiezhen Mo","orcid":"https://orcid.org/0000-0002-9404-3786","observed_orcids":["https://orcid.org/0000-0002-9404-3786"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jiezhen Mo","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070110411","display_name":"Daryl Zhong Hao Boey","orcid":"https://orcid.org/0000-0001-5770-3709","observed_orcids":["https://orcid.org/0000-0001-5770-3709"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daryl Boey","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000249682","display_name":"Chenyan Wu","orcid":"https://orcid.org/0000-0002-8456-3825","observed_orcids":["https://orcid.org/0000-0002-8456-3825"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Chenyan Wu","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116229112","display_name":"Magnus Tronstad","orcid":"https://orcid.org/0009-0009-1307-6948","observed_orcids":["https://orcid.org/0009-0009-1307-6948"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Magnus Tronstad","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023545163","display_name":"Lucille Margerie","orcid":"https://orcid.org/0000-0001-9537-1231","observed_orcids":["https://orcid.org/0000-0001-9537-1231"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lucille Margerie","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0001-9537-1231","affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106460715","display_name":"Remi\u2010Andr\u00e9 Olsen","orcid":"https://orcid.org/0009-0002-8357-5186","observed_orcids":["https://orcid.org/0009-0002-8357-5186"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Remi\u2010Andr\u00e9 Olsen","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Science for Life Laboratory Stockholm University  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Science for Life Laboratory Stockholm University  Stockholm Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006016525","display_name":"J\u00f6rg A. Bachmann","orcid":"https://orcid.org/0000-0002-7212-813X","observed_orcids":["https://orcid.org/0000-0002-7212-813X"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]},{"id":"https://openalex.org/I2800139495","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22","country_code":"SE","type":"facility","lineage":["https://openalex.org/I2800139495"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg A. Bachmann","raw_affiliation_strings":["Department of Biochemistry and Biophysics, Science for Life Laboratory Stockholm University  Stockholm Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Science for Life Laboratory Stockholm University  Stockholm Sweden","institution_ids":["https://openalex.org/I161593684","https://openalex.org/I2800139495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043150099","display_name":"Jing Hui Low","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jing Hui Low","raw_affiliation_strings":["Singapore Immunology Network (SIgN), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network (SIgN), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112912445","display_name":"Jocelyn Ong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Jocelyn Ong","raw_affiliation_strings":["Singapore Immunology Network (SIgN), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network (SIgN), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012439436","display_name":"Lars Heede Blom","orcid":"https://orcid.org/0000-0003-2027-727X","observed_orcids":["https://orcid.org/0000-0003-2027-727X"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Lars Heede Blom","raw_affiliation_strings":["Allergy Clinic, Department of Dermatology and Allergy Herlev and Gentofte University Hospital  Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2027-727X","affiliations":[{"raw_affiliation_string":"Allergy Clinic, Department of Dermatology and Allergy Herlev and Gentofte University Hospital  Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035499204","display_name":"Anand Kumar Andiappan","orcid":"https://orcid.org/0000-0002-8442-1544","observed_orcids":["https://orcid.org/0000-0002-8442-1544"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anand Kumar Andiappan","raw_affiliation_strings":["A*STAR Skin Research Labs (A*SRL), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore","Singapore Immunology Network (SIgN), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A*STAR Skin Research Labs (A*SRL), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore","institution_ids":["https://openalex.org/I115228651"]},{"raw_affiliation_string":"Singapore Immunology Network (SIgN), agency for Science Technology and Research (A*STAR)  Singapore Republic of Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016859188","display_name":"Gunnar P. Nilsson","orcid":"https://orcid.org/0000-0001-6795-5512","observed_orcids":["https://orcid.org/0000-0001-6795-5512"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunnar Nilsson","raw_affiliation_strings":["Department of Medical Sciences Uppsala University  Uppsala Sweden","Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0001-6795-5512","affiliations":[{"raw_affiliation_string":"Department of Medical Sciences Uppsala University  Uppsala Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085510498","display_name":"Joakim S. Dahlin","orcid":"https://orcid.org/0000-0003-3007-9875","observed_orcids":["https://orcid.org/0000-0003-3007-9875"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Joakim S. Dahlin","raw_affiliation_strings":["Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden"],"raw_orcid":"https://orcid.org/0000-0003-3007-9875","affiliations":[{"raw_affiliation_string":"Division of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, and Center for Molecular Medicine and Karolinska University Hospital  Stockholm Sweden","institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5085510498"],"corresponding_institution_ids":["https://openalex.org/I1335113835","https://openalex.org/I28166907"],"apc_list":{"value":5300,"currency":"USD","value_usd":5300},"apc_paid":{"value":5300,"currency":"USD","value_usd":5300},"fwci":7.7336,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.96836942,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"81","issue":"6","first_page":"2059","last_page":"2068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.10920000076293945,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/basophils","display_name":"basophils","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cell-surface-markers","display_name":"cell surface markers","score":0.7139999866485596},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cite-seq","display_name":"CITE-seq","score":0.7620000243186951},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.703000009059906},{"id":"https://openalex.org/keywords/long-read-rna-sequencing","display_name":"long-read RNA sequencing","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6912999749183655},{"id":"https://openalex.org/C2777456892","wikidata":"https://www.wikidata.org/wiki/Q107988","display_name":"Basophil","level":4,"score":0.6154999732971191},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5575000047683716},{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.4253999888896942},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3815000057220459},{"id":"https://openalex.org/C206345919","wikidata":"https://www.wikidata.org/wiki/Q20380951","display_name":"Resource (disambiguation)","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3521000146865845},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3361999988555908},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31380000710487366},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3061999976634979},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28999999165534973},{"id":"https://openalex.org/C2987857752","wikidata":"https://www.wikidata.org/wiki/Q12147","display_name":"Human health","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2694999873638153},{"id":"https://openalex.org/C3018243681","wikidata":"https://www.wikidata.org/wiki/Q19088","display_name":"Eukaryotic cell","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.25209999084472656},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/all.70209","doi":"https://doi.org/10.1111/all.70209","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.70209","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.70209","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.20.639059","doi":"https://doi.org/10.1101/2025.02.20.639059","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.02.20.639059","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41498390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41498390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13256280","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13256280/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13256280/pdf/ALL-81-2059.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Allergy","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/all.70209","doi":"https://doi.org/10.1111/all.70209","is_oa":true,"landing_page_url":"https://doi.org/10.1111/all.70209","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.70209","source":{"id":"https://openalex.org/S68090385","display_name":"Allergy","issn_l":"0105-4538","issn":["0105-4538","1398-9995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3451876804","display_name":"Single-cell multi-omics analysis charts the basophil and mast cell differentiation trajectories in normal and aberrant hematopoiesis","funder_award_id":"2022-00558","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G4632909464","display_name":null,"funder_award_id":"2022-06725","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G8869864247","display_name":"NAISS","funder_award_id":"2022-06725","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320321491","display_name":"Cancerfonden","ror":"https://ror.org/0527jb766"},{"id":"https://openalex.org/F4320322315","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320323220","display_name":"Alexander S. Onassis Public Benefit Foundation","ror":"https://ror.org/017nq0d63"},{"id":"https://openalex.org/F4320325677","display_name":"Science for Life Laboratory","ror":"https://ror.org/04ev03g22"},{"id":"https://openalex.org/F4320336376","display_name":"Uppsala Multidisciplinary Center for Advanced Computational Science","ror":"https://ror.org/0554ckj21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7118724916.pdf","grobid_xml":"https://content.openalex.org/works/W7118724916.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W237995705","https://openalex.org/W1971905966","https://openalex.org/W2005851413","https://openalex.org/W2035700261","https://openalex.org/W2047787274","https://openalex.org/W2088976989","https://openalex.org/W2739492614","https://openalex.org/W2911922390","https://openalex.org/W3092450628","https://openalex.org/W3093971913","https://openalex.org/W3132523507","https://openalex.org/W3164692211","https://openalex.org/W4220808341","https://openalex.org/W4292544198","https://openalex.org/W4323044982","https://openalex.org/W4361270405","https://openalex.org/W4398765545","https://openalex.org/W4399551757","https://openalex.org/W4400082517","https://openalex.org/W4404566604"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Basophils":[2],"are":[3],"implicated":[4],"in":[5,195],"various":[6],"diseases":[7],"including":[8],"allergies,":[9],"but":[10],"a":[11,28,163,179,184],"comprehensive":[12],"single\u2010cell":[13,29,73,102,141,165],"characterization":[14],"of":[15,33,62,90,147,193],"human":[16,35],"basophils":[17,56,194],"has":[18],"yet":[19],"to":[20,26,46,78],"be":[21],"performed.":[22],"Here,":[23],"we":[24],"aimed":[25],"generate":[27],"omics\u2010based":[30],"reference":[31,188],"resource":[32,166],"circulating":[34],"basophils,":[36],"integrating":[37],"transcriptomic":[38,81],"and":[39,64,71,88,117,151,186,197],"large\u2010scale":[40],"immunoprofiling":[41],"data.":[42,82],"We":[43,161],"also":[44],"sought":[45],"investigate":[47],"basophil":[48,109,173],"heterogeneity":[49],"at":[50],"the":[51,80,123,126,145,148],"molecular":[52,187],"level.":[53],"Methods":[54],"Circulating":[55],"were":[57,76],"analyzed":[58],"using":[59],"cellular":[60,185],"indexing":[61],"transcriptomes":[63],"epitopes":[65],"by":[66,112],"sequencing":[67],"(CITE\u2010seq).":[68],"Both":[69],"short\u2010":[70],"long\u2010read":[72],"RNA\u2010sequencing":[74,103,142],"platforms":[75],"used":[77],"capture":[79],"Results":[83],"CITE\u2010seq":[84],"enabled":[85],"accurate":[86],"identification":[87],"profiling":[89],"side":[91],"scatter":[92],"low":[93],"lineage":[94],"\u2212":[95],"CCR3":[96],"+":[97,99],"Fc\u03b5RI":[98],"basophils.":[100],"Short\u2010read":[101],"data":[104],"revealed":[105],"two":[106,149,169],"previously":[107],"unresolved":[108],"populations,":[110],"defined":[111],"66":[113],"differentially":[114],"expressed":[115],"genes":[116],"reproducibly":[118],"identified":[119],"across":[120],"donors.":[121],"Despite":[122],"transcriptional":[124],"differences,":[125],"populations":[127,150],"displayed":[128],"similar":[129],"immunophenotypes":[130],"based":[131],"on":[132],"more":[133],"than":[134],"100":[135],"investigated":[136],"cell":[137],"surface":[138],"markers.":[139],"Long\u2010read":[140],"analysis":[143],"confirmed":[144],"existence":[146],"provided":[152],"further":[153],"insights":[154],"into":[155],"their":[156],"gene":[157],"expression":[158],"profiles.":[159],"Conclusions":[160],"present":[162],"multimodal":[164],"that":[167],"defines":[168],"novel":[170],"transcriptionally":[171],"distinct":[172],"populations.":[174],"This":[175],"resource,":[176],"accessible":[177],"through":[178],"user\u2010friendly":[180],"web":[181],"interface,":[182],"constitutes":[183],"map":[189],"for":[190],"future":[191],"studies":[192],"health":[196],"disease.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-01-08T00:00:00"}
