{"id":"https://openalex.org/W7118635536","doi":"https://doi.org/10.3389/fddev.2025.1700455","title":"Anti-HER2-targeted therapies: effects on human in vitro blood-brain barrier models","display_name":"Anti-HER2-targeted therapies: effects on human in vitro blood-brain barrier models","publication_year":2026,"publication_date":"2026-01-07","ids":{"openalex":"https://openalex.org/W7118635536","doi":"https://doi.org/10.3389/fddev.2025.1700455","pmid":"https://pubmed.ncbi.nlm.nih.gov/41574208"},"language":"en","primary_location":{"id":"doi:10.3389/fddev.2025.1700455","doi":"https://doi.org/10.3389/fddev.2025.1700455","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fddev.2025.1700455","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2025.1700455/pdf","source":{"id":"https://openalex.org/S4386621893","display_name":"Frontiers in Drug Delivery","issn_l":"2674-0850","issn":["2674-0850"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2025.1700455/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025966390","display_name":"Carolin Julia Curtaz","orcid":"https://orcid.org/0000-0002-3574-4005","observed_orcids":["https://orcid.org/0000-0002-3574-4005"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin J. Curtaz","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rebecca Gebert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rebecca Gebert","raw_affiliation_strings":["Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112839389","display_name":"Achim W\u00f6ckel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Achim W\u00f6ckel","raw_affiliation_strings":["Department of Gynecology and Obstetrics, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004835573","display_name":"Patrick Meybohm","orcid":"https://orcid.org/0000-0002-2666-8696","observed_orcids":["https://orcid.org/0000-0002-2666-8696"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Meybohm","raw_affiliation_strings":["Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085232992","display_name":"Ma\u0142gorzata Burek","orcid":"https://orcid.org/0000-0001-6148-2195","observed_orcids":["https://orcid.org/0000-0001-6148-2195"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Malgorzata Burek","raw_affiliation_strings":["Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital W\u00fcrzburg, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085232992"],"corresponding_institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":2.5279,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83022343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"5","issue":null,"first_page":"1700455","last_page":"1700455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9409999847412109},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.8709999918937683},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9079999923706055},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":1.0},{"id":"https://openalex.org/keywords/lapatinib","display_name":"lapatinib","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tucatinib","display_name":"tucatinib","score":1.0},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.6660000085830688},{"id":"https://openalex.org/keywords/hcmec-d3","display_name":"hCMEC/D3","score":0.925000011920929},{"id":"https://openalex.org/keywords/transendothelial-electrical-resistance","display_name":"transendothelial electrical resistance","score":0.8849999904632568},{"id":"https://openalex.org/keywords/endothelial-permeability","display_name":"endothelial permeability","score":0.7250000238418579},{"id":"https://openalex.org/keywords/efflux-pumps","display_name":"efflux pumps","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.871999979019165},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.8180000185966492},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.8500000238418579},{"id":"https://openalex.org/keywords/claudin-5","display_name":"claudin-5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9480000138282776},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2777329042","wikidata":"https://www.wikidata.org/wiki/Q420323","display_name":"Lapatinib","level":5,"score":0.7087000012397766},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5544999837875366},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.515999972820282},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.47760000824928284},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.47620001435279846},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4343999922275543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4207000136375427},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.41119998693466187},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.3874000012874603},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3540000021457672},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3528999984264374},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.3334999978542328},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.32919999957084656},{"id":"https://openalex.org/C179661763","wikidata":"https://www.wikidata.org/wiki/Q21113119","display_name":"CXCL2","level":5,"score":0.3188999891281128},{"id":"https://openalex.org/C2779880527","wikidata":"https://www.wikidata.org/wiki/Q4959796","display_name":"Breast disease","level":4,"score":0.3100000023841858},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.3082999885082245},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30059999227523804},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.2939999997615814},{"id":"https://openalex.org/C193176779","wikidata":"https://www.wikidata.org/wiki/Q5016050","display_name":"Caco-2","level":3,"score":0.2935999929904938},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.27889999747276306},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C512196","wikidata":"https://www.wikidata.org/wiki/Q4650095","display_name":"Abcg2","level":5,"score":0.2777999937534332},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.27459999918937683},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26010000705718994},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.25870001316070557}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fddev.2025.1700455","doi":"https://doi.org/10.3389/fddev.2025.1700455","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fddev.2025.1700455","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2025.1700455/pdf","source":{"id":"https://openalex.org/S4386621893","display_name":"Frontiers in Drug Delivery","issn_l":"2674-0850","issn":["2674-0850"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Drug Delivery","raw_type":"journal-article"},{"id":"pmid:41574208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41574208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in drug delivery","raw_type":"Journal Article"},{"id":"pmh:oai:opus.bibliothek.uni-wuerzburg.de:43874","doi":null,"is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-438740","pdf_url":null,"source":{"id":"https://openalex.org/S4306401635","display_name":"Online Publication Service of W\u00fcrzburg University (W\u00fcrzburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I25974101","host_organization_name":"University of W\u00fcrzburg","host_organization_lineage":["https://openalex.org/I25974101"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12819789","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12819789/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Drug Deliv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/fddev.2025.1700455","doi":"https://doi.org/10.3389/fddev.2025.1700455","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fddev.2025.1700455","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/drug-delivery/articles/10.3389/fddev.2025.1700455/pdf","source":{"id":"https://openalex.org/S4386621893","display_name":"Frontiers in Drug Delivery","issn_l":"2674-0850","issn":["2674-0850"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Drug Delivery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.6757758259773254}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332076","display_name":"Vogel Stiftung","ror":"https://ror.org/03qqaft37"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7118635536.pdf","grobid_xml":"https://content.openalex.org/works/W7118635536.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1969580999","https://openalex.org/W1978863320","https://openalex.org/W2031675248","https://openalex.org/W2046895286","https://openalex.org/W2052578334","https://openalex.org/W2056856515","https://openalex.org/W2107325549","https://openalex.org/W2107798346","https://openalex.org/W2110444464","https://openalex.org/W2136504773","https://openalex.org/W2139085578","https://openalex.org/W2161888863","https://openalex.org/W2164190676","https://openalex.org/W2277219084","https://openalex.org/W2519946849","https://openalex.org/W2551079320","https://openalex.org/W2611412318","https://openalex.org/W2742070230","https://openalex.org/W2743362345","https://openalex.org/W2756562465","https://openalex.org/W2799868296","https://openalex.org/W3020093841","https://openalex.org/W3024580289","https://openalex.org/W3030461309","https://openalex.org/W3049428549","https://openalex.org/W3157950444","https://openalex.org/W3216658647","https://openalex.org/W4206166022","https://openalex.org/W4212864919","https://openalex.org/W4214500240","https://openalex.org/W4221104895","https://openalex.org/W4281786463","https://openalex.org/W4283260308","https://openalex.org/W4285028518","https://openalex.org/W4286587274","https://openalex.org/W4290673816","https://openalex.org/W4306849886","https://openalex.org/W4309313960","https://openalex.org/W4310566600","https://openalex.org/W4312067218","https://openalex.org/W4360992863","https://openalex.org/W4366463033","https://openalex.org/W4400099408","https://openalex.org/W4404452346","https://openalex.org/W4405314873"],"related_works":[],"abstract_inverted_index":{"Metastatic":[0],"breast":[1,17,45,234],"cancer":[2,18,46,235],"is":[3],"associated":[4],"with":[5,93,143,156,179],"very":[6],"poor":[7],"overall":[8],"survival":[9],"and":[10,34,39,86,106,121,134,145,181,211,222],"a":[11,157],"reduced":[12],"quality":[13],"of":[14,52,58,96,136,141,160,190,225,231,251],"life.":[15],"HER2-positive":[16,44,233],"forms":[19],"brain":[20],"metastases":[21],"at":[22,147],"the":[23,50,56,59,187,200,212,229,237,248],"late":[24],"stages.":[25],"Established":[26],"therapies":[27,54,227],"such":[28],"as":[29],"trastuzumab,":[30,97],"pertuzumab,":[31,98],"trastuzumab/pertuzumab,":[32,99],"lapatinib":[33,100,144],"tucatinib":[35,102,146],"are":[36,40,244],"widely":[37],"used":[38],"selectively":[41],"toxic":[42,165],"to":[43,119,246],"cell":[47,88,111,131,153],"line.":[48,89],"However,":[49],"effects":[51,224],"these":[53],"on":[55,130,236],"properties":[57],"blood-brain":[60],"barrier":[61],"(BBB)":[62],"remain":[63],"unclear.":[64],"We":[65,109],"investigated":[66],"this":[67],"using":[68,171],"an":[69],"in":[70,151,164,174,184,186,239],"vitro":[71,175,240],"human":[72],"BBB":[73,173,191,238],"model":[74],"derived":[75],"from":[76],"CD34":[77],"+":[78],"cells":[79,84],"differentiated":[80],"into":[81],"brain-like":[82],"endothelial":[83,137],"(BLECs)":[85],"hCMEC/D3":[87],"BLECs":[90,142],"were":[91,169],"treated":[92],"different":[94,220],"concentrations":[95,149],"or":[101],"for":[103,228],"24":[104],"h":[105],"48":[107],"h.":[108],"measured":[110],"viability,":[112,132],"transendothelial":[113],"electrical":[114],"resistance":[115],"(TEER),":[116],"paracellular":[117],"permeability":[118,133],"fluorescein":[120],"mRNA":[122,188],"expression":[123,189],"profiles.":[124],"Most":[125],"treatments":[126],"showed":[127],"no":[128],"effect":[129],"TEER":[135],"cells.":[138],"While":[139],"treatment":[140,155,230],"low":[148],"resulted":[150,163,183],"increased":[152],"viability/metabolism,":[154],"higher":[158],"concentration":[159],"5":[161],"\u03bcg/mL":[162],"effects.":[166],"These":[167],"results":[168],"confirmed":[170],"another":[172],"model,":[176],"hCMEC/D3.":[177],"Treatment":[178],"trastuzumab":[180],"trastuzumab/pertuzumab":[182],"changes":[185],"marker":[192],"genes":[193],"encoding":[194],"efflux":[195],"pumps":[196],"(P-gp":[197],"(ABCB1)/BCRP":[198],"(ABCG2)),":[199],"glucose":[201],"transporter":[202],"GLUT-1":[203],"(SLC2A1),":[204],"tight":[205],"junction":[206],"proteins":[207],"(occludin":[208],"(OCLN)/claudin-5":[209],"(CLDN5))":[210],"pro-inflammatory":[213],"chemokine":[214],"CCL2.":[215],"In":[216],"conclusion,":[217],"we":[218],"demonstrate":[219],"time-":[221],"concentration-dependent":[223],"anti-HER2-targeted":[226],"advanced":[232],".":[241],"Further":[242],"experiments":[243],"required":[245],"assess":[247],"clinical":[249],"relevance":[250],"our":[252],"results.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2026-01-08T00:00:00"}
