{"id":"https://openalex.org/W7118635520","doi":"https://doi.org/10.21608/asfr.2025.437193.1092","title":"Effects of Dietary Pyrethroid (Cypermethrin) on the Growth Performance, Cholinesterase Enzyme Activity, and Tissue Histopathology of Nile Tilapia Oreochromis niloticus","display_name":"Effects of Dietary Pyrethroid (Cypermethrin) on the Growth Performance, Cholinesterase Enzyme Activity, and Tissue Histopathology of Nile Tilapia Oreochromis niloticus","publication_year":2025,"publication_date":"2025-12-30","ids":{"openalex":"https://openalex.org/W7118635520","doi":"https://doi.org/10.21608/asfr.2025.437193.1092"},"language":"en","primary_location":{"id":"doi:10.21608/asfr.2025.437193.1092","doi":"https://doi.org/10.21608/asfr.2025.437193.1092","is_oa":true,"landing_page_url":"https://doi.org/10.21608/asfr.2025.437193.1092","pdf_url":null,"source":{"id":"https://openalex.org/S4210193497","display_name":"Aquatic Science and Fish Resources (ASFR) /Aquatic Science and Fish Resources (ASFR)","issn_l":"2682-4086","issn":["2682-4086","2682-4108"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Science and Fish Resources (ASFR)","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21608/asfr.2025.437193.1092","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077532977","display_name":"Arjay Pataueg","orcid":"https://orcid.org/0000-0002-2776-1219","observed_orcids":["https://orcid.org/0000-0002-2776-1219"]},"institutions":[{"id":"https://openalex.org/I4405280403","display_name":"Cavite State University - Naic","ror":"https://ror.org/02wv29361","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210142002","https://openalex.org/I4405280403"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Arjay  Bongtiwon Pataueg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119009187","display_name":"Yves Roy M. Tibayan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142002","display_name":"Cavite State University","ror":"https://ror.org/043say313","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210142002"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Yves  Roy M. Tibayan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119009188","display_name":"Shiela Mae P. Tarucan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280403","display_name":"Cavite State University - Naic","ror":"https://ror.org/02wv29361","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210142002","https://openalex.org/I4405280403"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Shiela Mae  P. Tarucan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119009189","display_name":"Arnel Y. Rebato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405280403","display_name":"Cavite State University - Naic","ror":"https://ror.org/02wv29361","country_code":"PH","type":"education","lineage":["https://openalex.org/I4210142002","https://openalex.org/I4405280403"]}],"countries":["PH"],"is_corresponding":false,"raw_author_name":"Arnel  Y. Rebato","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014228089","display_name":"Uthpala M. Padeniya","orcid":"https://orcid.org/0000-0003-3436-1894","observed_orcids":["https://orcid.org/0000-0003-3436-1894"]},"institutions":[{"id":"https://openalex.org/I82497590","display_name":"Auburn University","ror":"https://ror.org/02v80fc35","country_code":"US","type":"education","lineage":["https://openalex.org/I82497590"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uthpala Padeniya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027428119","display_name":"Christopher Lyon Brown","orcid":"https://orcid.org/0000-0002-4578-3593","observed_orcids":["https://orcid.org/0000-0002-4578-3593"]},"institutions":[{"id":"https://openalex.org/I8991828","display_name":"Pukyong National University","ror":"https://ror.org/0433kqc49","country_code":"KR","type":"education","lineage":["https://openalex.org/I8991828"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Christopher  L. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39097932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"0","issue":"0","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cypermethrin","display_name":"cypermethrin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pyrethroid-insecticides","display_name":"pyrethroid insecticides","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oreochromis-niloticus","display_name":"Oreochromis niloticus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dietary-pesticide-exposure","display_name":"dietary pesticide exposure","score":0.7360000014305115},{"id":"https://openalex.org/keywords/growth-performance","display_name":"growth performance","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cholinesterase-activity","display_name":"cholinesterase activity","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brain-cholinesterase","display_name":"brain cholinesterase","score":0.7400000095367432},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.8899999856948853},{"id":"https://openalex.org/keywords/toxicity-thresholds","display_name":"toxicity thresholds","score":0.6549999713897705},{"id":"https://openalex.org/keywords/fish-feed-contamination","display_name":"fish feed contamination","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C2778658382","wikidata":"https://www.wikidata.org/wiki/Q4621959","display_name":"Oreochromis","level":3,"score":0.9283000230789185},{"id":"https://openalex.org/C2780129523","wikidata":"https://www.wikidata.org/wiki/Q311170","display_name":"Nile tilapia","level":4,"score":0.8833000063896179},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7088000178337097},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.6865000128746033},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.6847000122070312},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46799999475479126},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.453000009059906},{"id":"https://openalex.org/C22830521","wikidata":"https://www.wikidata.org/wiki/Q649967","display_name":"Feed conversion ratio","level":3,"score":0.42250001430511475},{"id":"https://openalex.org/C2911062015","wikidata":"https://www.wikidata.org/wiki/Q110577","display_name":"Coregonus clupeaformis","level":3,"score":0.4212000072002411},{"id":"https://openalex.org/C2779286987","wikidata":"https://www.wikidata.org/wiki/Q47793","display_name":"Tilapia","level":3,"score":0.41510000824928284},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.4120999872684479},{"id":"https://openalex.org/C2779437720","wikidata":"https://www.wikidata.org/wiki/Q412024","display_name":"Cypermethrin","level":3,"score":0.39629998803138733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3723999857902527},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.35359999537467957},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3221000134944916},{"id":"https://openalex.org/C2780138947","wikidata":"https://www.wikidata.org/wiki/Q393855","display_name":"Dry matter","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C46254838","wikidata":"https://www.wikidata.org/wiki/Q5156536","display_name":"Completely randomized design","level":2,"score":0.29260000586509705},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.27399998903274536},{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.26910001039505005}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.21608/asfr.2025.437193.1092","doi":"https://doi.org/10.21608/asfr.2025.437193.1092","is_oa":true,"landing_page_url":"https://doi.org/10.21608/asfr.2025.437193.1092","pdf_url":null,"source":{"id":"https://openalex.org/S4210193497","display_name":"Aquatic Science and Fish Resources (ASFR) /Aquatic Science and Fish Resources (ASFR)","issn_l":"2682-4086","issn":["2682-4086","2682-4108"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Science and Fish Resources (ASFR)","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5354272","doi":"https://doi.org/10.2139/ssrn.5354272","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5354272","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21608/asfr.2025.437193.1092","doi":"https://doi.org/10.21608/asfr.2025.437193.1092","is_oa":true,"landing_page_url":"https://doi.org/10.21608/asfr.2025.437193.1092","pdf_url":null,"source":{"id":"https://openalex.org/S4210193497","display_name":"Aquatic Science and Fish Resources (ASFR) /Aquatic Science and Fish Resources (ASFR)","issn_l":"2682-4086","issn":["2682-4086","2682-4108"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Science and Fish Resources (ASFR)","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.9208999872207642}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.6299000978469849}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W33469685","https://openalex.org/W263997924","https://openalex.org/W1511377738","https://openalex.org/W1971146568","https://openalex.org/W1974126049","https://openalex.org/W1989848826","https://openalex.org/W1994259055","https://openalex.org/W2008059919","https://openalex.org/W2012361130","https://openalex.org/W2017659703","https://openalex.org/W2027956912","https://openalex.org/W2042734720","https://openalex.org/W2068561081","https://openalex.org/W2081519756","https://openalex.org/W2090048349","https://openalex.org/W2104344865","https://openalex.org/W2114891756","https://openalex.org/W2117937820","https://openalex.org/W2273287350","https://openalex.org/W2318487204","https://openalex.org/W2604995257","https://openalex.org/W2620902476","https://openalex.org/W2748268306","https://openalex.org/W2781614204","https://openalex.org/W2927726339","https://openalex.org/W2954932593","https://openalex.org/W3010455025","https://openalex.org/W3093845670","https://openalex.org/W3128556577","https://openalex.org/W3176180285","https://openalex.org/W3206186505","https://openalex.org/W4200170441","https://openalex.org/W4211106922","https://openalex.org/W4280531810","https://openalex.org/W4281678330","https://openalex.org/W4295221628","https://openalex.org/W4297464109","https://openalex.org/W4312774894","https://openalex.org/W4313647340","https://openalex.org/W4382776506","https://openalex.org/W4389398714","https://openalex.org/W4392959383","https://openalex.org/W4399327461","https://openalex.org/W4400108663","https://openalex.org/W4402642103","https://openalex.org/W7037005945"],"related_works":[],"abstract_inverted_index":{"An":[0],"eight-week":[1],"feeding":[2,248],"trial":[3],"was":[4],"conducted":[5],"to":[6,33,97,147,183,188,214],"investigate":[7],"the":[8,15,170,196,229],"effects":[9],"of":[10,23,52,55,87,160,163,173,186,200,233,247],"dietary":[11,184,234],"Cypermethrin":[12],"(CYP)":[13],"on":[14,220],"growth":[16,81],"performance,":[17],"cholinesterase":[18,132,198,210],"activities,":[19],"and":[20,43,66,83,91,109,128,134,141,165],"tissue":[21],"histopathology":[22],"Nile":[24,57],"tilapia":[25,58],"(O.":[26],"niloticus).":[27],"Five":[28],"experimental":[29],"diets":[30],"were":[31,60,67,93,111,123,143,167],"formulated":[32],"contain":[34],"0":[35],"(CYP0),":[36],"1":[37],"(CYP1),":[38],"5":[39],"(CYP5),":[40],"25":[41],"(CYP25),":[42],"50":[44],"(CYP50)":[45],"mg":[46],"CYP/100g":[47,216],"feed":[48,190,217],"diet.":[49,218],"A":[50],"total":[51,85],"450":[53],"pcs":[54],"Juvenile":[56],"(5.35\u00b10.47g)":[59],"randomly":[61],"distributed":[62],"into":[63],"15":[64],"tanks":[65],"fed":[68,89],"twice":[69],"daily":[70],"for":[71,224],"eight":[72,245],"weeks.":[73],"Results":[74],"showed":[75],"that":[76,181],"fish":[77,88,101,120,174],"body":[78,102,225],"weight,":[79],"specific":[80],"rate,":[82],"final":[84],"length":[86],"CYP25":[90],"CYP50":[92,110,142],"significantly":[94,112,144,194,206],"reduced":[95,145],"compared":[96,146],"CYP0,":[98,126,148],"(p<0.05).":[99,116,130],"The":[100,117],"weight":[103,226],"gain":[104,227],"in":[105,125,137,169,236],"treatments":[106,138],"CYP5,":[107,129,139],"CYP25,":[108,140],"lower":[113],"than":[114],"CYP0":[115],"most":[118],"favorable":[119],"conversion":[121],"ratio":[122],"found":[124],"CYP1,":[127],"Liver":[131],"(AChE":[133],"BChE)":[135],"activities":[136,199,211],"p<0.05.":[149],"Necrosis,":[150],"edema,":[151],"mononuclear":[152],"cell":[153],"infiltration,":[154],"villi":[155],"fusion,":[156],"hypertrophy,":[157],"congestion,":[158],"dilation":[159],"sinusoids,":[161],"degeneration":[162],"nerves":[164],"fibers":[166],"evident":[168],"sampled":[171],"tissues":[172],"treated":[175],"with":[176],"CYP.":[177],"This":[178],"study":[179],"suggests":[180],"exposure":[182],"CYP":[185,235],"up":[187],"50mg/100g":[189],"diet":[191],"may":[192],"not":[193],"affect":[195],"brain":[197],"O.":[201,237],"niloticus.":[202],"However,":[203],"it":[204],"will":[205],"decrease":[207],"its":[208],"liver":[209],"when":[212],"exposed":[213],"5mg":[215],"Based":[219],"broken-line":[221],"regression":[222],"model":[223],"(%),":[228],"threshold":[230],"toxicity":[231],"level":[232],"niloticus":[238],"could":[239],"be":[240],"approximately":[241],"1.075mg/100g":[242],"feed,":[243],"over":[244],"weeks":[246],"period.":[249]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-01-08T00:00:00"}