{"id":"https://openalex.org/W7118564656","doi":"https://doi.org/10.5281/zenodo.18151652","title":"BEYOND THE NEEDLE: ADVANCES AND FUTURE PROSPECTS IN NEEDLE-FREE INJECTION SYSTEMS","display_name":"BEYOND THE NEEDLE: ADVANCES AND FUTURE PROSPECTS IN NEEDLE-FREE INJECTION SYSTEMS","publication_year":2026,"publication_date":"2026-01-05","ids":{"openalex":"https://openalex.org/W7118564656","doi":"https://doi.org/10.5281/zenodo.18151652"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.18151652","doi":"https://doi.org/10.5281/zenodo.18151652","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18151652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.18151652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122210663","display_name":"1*Gattu Jyothi, 2Kaithoju Sravya, 3Kanche Niharika, 4Kasala Akash, 5Kali Kavyasri, 6Kalapala Pandu Ranga Deepika","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"1*Gattu Jyothi, 2Kaithoju Sravya, 3Kanche Niharika, 4Kasala Akash, 5Kali Kavyasri, 6Kalapala Pandu Ranga Deepika","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5122210663"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00894712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parenteral-drug-delivery","display_name":"parenteral drug delivery","score":0.9649999737739563},{"id":"https://openalex.org/keywords/painless-injection","display_name":"painless injection","score":0.6809999942779541},{"id":"https://openalex.org/keywords/insulin-delivery","display_name":"insulin delivery","score":0.7210000157356262},{"id":"https://openalex.org/keywords/vaccine-delivery","display_name":"vaccine delivery","score":0.9340000152587891},{"id":"https://openalex.org/keywords/drug-self-administration","display_name":"self-administration","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.824999988079071},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"nanotechnology","score":0.8999999761581421},{"id":"https://openalex.org/keywords/formulation-stability","display_name":"formulation stability","score":0.6290000081062317},{"id":"https://openalex.org/keywords/needle-phobia","display_name":"needle phobia","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2994527087","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin delivery","level":4,"score":0.5367000102996826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5078999996185303},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4650000035762787},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.40290001034736633},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.364300012588501},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.34209999442100525},{"id":"https://openalex.org/C2983266536","wikidata":"https://www.wikidata.org/wiki/Q3509543","display_name":"Electronic systems","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32359999418258667},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3077999949455261},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C2984430287","wikidata":"https://www.wikidata.org/wiki/Q186249","display_name":"Pharmaceutical technology","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2924000024795532},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2750999927520752},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.262800008058548}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.18151652","doi":"https://doi.org/10.5281/zenodo.18151652","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18151652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.18151653","doi":"https://doi.org/10.5281/zenodo.18151653","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18151653","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.18151652","doi":"https://doi.org/10.5281/zenodo.18151652","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.18151652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.45275750756263733,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Conventional":[0],"needle-based":[1],"injections":[2,141],"have":[3],"long":[4],"been":[5],"central":[6],"to":[7,56],"parenteral":[8],"drug":[9],"delivery,":[10],"but":[11],"they":[12],"are":[13],"often":[14],"linked":[15],"with":[16,105],"pain,":[17],"needle":[18],"phobia,":[19],"infection":[20],"risk,":[21],"and":[22,34,77,87,95,102,109,115,126,138],"poor":[23],"patient":[24],"compliance.":[25],"To":[26],"overcome":[27],"these":[28],"issues,":[29],"the":[30,40,63,70],"demand":[31],"for":[32,82],"painless":[33,140],"user-friendly":[35],"delivery":[36,100],"methods":[37],"has":[38],"driven":[39],"development":[41],"of":[42],"needle-free":[43],"injection":[44],"systems":[45],"(NFIS).":[46],"These":[47],"devices":[48],"use":[49],"high-pressure":[50],"gas,":[51],"springs,":[52],"or":[53,59],"electronic":[54,96],"mechanisms":[55],"propel":[57],"liquid":[58],"powdered":[60],"drugs":[61],"through":[62],"skin":[64],"without":[65],"a":[66,132],"needle.":[67],"By":[68],"removing":[69],"needle,":[71],"NFIS":[72,130],"minimise":[73],"cross-contamination,":[74],"improve":[75],"comfort,":[76],"support":[78],"easier":[79],"self-administration,":[80],"especially":[81],"chronic":[83],"treatments":[84],"like":[85],"insulin":[86],"vaccines.":[88],"Recent":[89],"advances\u2014including":[90],"micro-jet":[91],"injectors,":[92],"micro-needle":[93],"patches,":[94],"precision":[97],"systems\u2014have":[98],"enhanced":[99],"accuracy":[101],"control.":[103],"Integration":[104],"digital":[106],"tools,":[107],"microfluidics,":[108],"nanotechnology":[110],"is":[111],"enabling":[112],"more":[113],"personalised":[114],"data-driven":[116],"therapy.":[117],"Although":[118],"challenges":[119],"such":[120],"as":[121],"formulation":[122],"stability,":[123],"device":[124],"cost,":[125],"regulatory":[127],"barriers":[128],"remain,":[129],"offer":[131],"promising":[133],"step":[134],"toward":[135],"safer,":[136],"precise,":[137],"nearly":[139],"in":[142],"modern":[143],"healthcare.":[144]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-01-08T00:00:00"}