{"id":"https://openalex.org/W7118176552","doi":"https://doi.org/10.1038/s44161-025-00762-7","title":"Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization","display_name":"Sphingosine kinase 1 is integral for elastin deficiency-induced arterial hypermuscularization","publication_year":2026,"publication_date":"2026-01-05","ids":{"openalex":"https://openalex.org/W7118176552","doi":"https://doi.org/10.1038/s44161-025-00762-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/41492020","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13091694"},"language":"en","primary_location":{"id":"doi:10.1038/s44161-025-00762-7","doi":"https://doi.org/10.1038/s44161-025-00762-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s44161-025-00762-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210241135","display_name":"Nature Cardiovascular Research","issn_l":"2731-0590","issn":["2731-0590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/41492020/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121925771","display_name":"Junichi Saito","orcid":"https://orcid.org/0000-0002-4297-727X","observed_orcids":["https://orcid.org/0000-0002-4297-727X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junichi Saito","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, CT, USA. jsaito@augusta.edu","Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA. jsaito@augusta.edu","Stem Cell Center, Yale University, New Haven, CT, USA. jsaito@augusta.edu"],"raw_orcid":"https://orcid.org/0000-0002-4297-727X","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, CT, USA. jsaito@augusta.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA. jsaito@augusta.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University, New Haven, CT, USA. jsaito@augusta.edu","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033014407","display_name":"Jui M. Dave","orcid":"https://orcid.org/0000-0002-5448-4798","observed_orcids":["https://orcid.org/0000-0002-5448-4798"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jui M. Dave","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, CT, USA","Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","Stem Cell Center, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014772959","display_name":"Eunate Gallardo\u2010Vara","orcid":"https://orcid.org/0000-0003-4733-0878","observed_orcids":["https://orcid.org/0000-0003-4733-0878"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eunate Gallardo-Vara","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, CT, USA","Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","Stem Cell Center, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089239318","display_name":"Nandhini Sadagopan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nandhini Sadagopan","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, CT, USA","Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","Stem Cell Center, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084795666","display_name":"Inamul Kabir","orcid":"https://orcid.org/0000-0001-6207-1785","observed_orcids":["https://orcid.org/0000-0001-6207-1785"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Inamul Kabir","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, CT, USA","Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","Stem Cell Center, Yale University, New Haven, CT, USA"],"raw_orcid":"https://orcid.org/0000-0001-6207-1785","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036202065","display_name":"George Tellides","orcid":"https://orcid.org/0000-0001-7042-8190","observed_orcids":["https://orcid.org/0000-0001-7042-8190"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Tellides","raw_affiliation_strings":["Department of Surgery, Yale University, New Haven, CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yale University, New Haven, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070692165","display_name":"Robert Kirk Riemer","orcid":"https://orcid.org/0000-0002-3054-9809","observed_orcids":["https://orcid.org/0000-0002-3054-9809"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert K. Riemer","raw_affiliation_strings":["Congenital Division, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Congenital Division, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056895680","display_name":"Zsolt Urb\u00e1n","orcid":"https://orcid.org/0000-0003-3890-1843","observed_orcids":["https://orcid.org/0000-0003-3890-1843"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zsolt Urban","raw_affiliation_strings":["Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100042133","display_name":"Sarah Spiegel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Spiegel","raw_affiliation_strings":["Department of Cellular, Molecular and Genetic Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular, Molecular and Genetic Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006724562","display_name":"Timothy Hla","orcid":"https://orcid.org/0000-0001-8355-4065","observed_orcids":["https://orcid.org/0000-0001-8355-4065"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Hla","raw_affiliation_strings":["Department of Surgery, Harvard Medical School, Boston, MA, USA","Vascular Biology Program, Boston Children's Hospital, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-8355-4065","affiliations":[{"raw_affiliation_string":"Department of Surgery, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Vascular Biology Program, Boston Children's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088025612","display_name":"Daniel M. Greif","orcid":"https://orcid.org/0000-0002-9842-3751","observed_orcids":["https://orcid.org/0000-0002-9842-3751"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel M. Greif","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, CT, USA. daniel.greif@yale.edu","Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA. daniel.greif@yale.edu","Stem Cell Center, Yale University, New Haven, CT, USA. daniel.greif@yale.edu"],"raw_orcid":"https://orcid.org/0000-0002-9842-3751","affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, CT, USA. daniel.greif@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Internal Medicine, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA. daniel.greif@yale.edu","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Stem Cell Center, Yale University, New Haven, CT, USA. daniel.greif@yale.edu","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5088025612","https://openalex.org/A5121925771"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":4.0872,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90666759,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"5","issue":"1","first_page":"34","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.3359000086784363,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12272","display_name":"Cardiovascular Conditions and Treatments","score":0.13510000705718994,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.06300000101327896,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-kinase-1","display_name":"sphingosine kinase 1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/elastin-deficiency","display_name":"elastin deficiency","score":0.9869999885559082},{"id":"https://openalex.org/keywords/supravalvular-aortic-stenosis","display_name":"supravalvular aortic stenosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ductus-arteriosus-closure","display_name":"ductus arteriosus closure","score":0.9129999876022339},{"id":"https://openalex.org/keywords/smooth-muscle-cell-proliferation","display_name":"smooth muscle cell proliferation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/elastic-fibers","display_name":"elastic fibers","score":0.7160000205039978},{"id":"https://openalex.org/keywords/early-growth-response-1","display_name":"early growth response 1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/sphk1-inhibitors","display_name":"SphK1 inhibitors","score":0.8209999799728394},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.902999997138977},{"id":"https://openalex.org/keywords/aortic-disease","display_name":"aortic disease","score":0.5910000205039978}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8064000010490417},{"id":"https://openalex.org/C2777550365","wikidata":"https://www.wikidata.org/wiki/Q14913834","display_name":"Sphingosine kinase 1","level":5,"score":0.6550999879837036},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.6032999753952026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5235000252723694},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.4799000024795532},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.46860000491142273},{"id":"https://openalex.org/C2781236024","wikidata":"https://www.wikidata.org/wiki/Q1163923","display_name":"Ductus arteriosus","level":2,"score":0.4431000053882599},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4399999976158142},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43560001254081726},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4323999881744385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4090000092983246},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3959999978542328},{"id":"https://openalex.org/C2781290252","wikidata":"https://www.wikidata.org/wiki/Q16874615","display_name":"Supravalvular aortic stenosis","level":3,"score":0.38420000672340393},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.33079999685287476},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.29649999737739563},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2946000099182129},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.2856999933719635},{"id":"https://openalex.org/C2781285907","wikidata":"https://www.wikidata.org/wiki/Q616032","display_name":"Aortic arch","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2635999917984009},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.25839999318122864}],"mesh":[{"descriptor_ui":"D000099157","descriptor_name":"Sphingosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004374","descriptor_name":"Ductus Arteriosus, Patent","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004374","descriptor_name":"Ductus Arteriosus, Patent","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004374","descriptor_name":"Ductus Arteriosus, Patent","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D004549","descriptor_name":"Elastin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021921","descriptor_name":"Aortic Stenosis, Supravalvular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D021921","descriptor_name":"Aortic Stenosis, Supravalvular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021921","descriptor_name":"Aortic Stenosis, Supravalvular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s44161-025-00762-7","doi":"https://doi.org/10.1038/s44161-025-00762-7","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s44161-025-00762-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210241135","display_name":"Nature Cardiovascular Research","issn_l":"2731-0590","issn":["2731-0590"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-2","medline","norway-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Cardiovascular Research","raw_type":"journal-article"},{"id":"doi:10.1101/2024.07.01.601150","doi":"https://doi.org/10.1101/2024.07.01.601150","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2024.07.01.601150","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41492020","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41492020","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13091694","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41492020/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Cardiovasc Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13091694","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41492020/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Cardiovasc Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3907600513","display_name":null,"funder_award_id":"202260284","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4884405070","display_name":"Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularization","funder_award_id":"1k99hl171838-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6634842880","display_name":"Pathological arterial muscularization and the role of integrins","funder_award_id":"R01HL125815","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6685406427","display_name":null,"funder_award_id":"K99HL171838","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G738654424","display_name":"Role of sphingosine kinase 1 in supravalvular aortic stenosis","funder_award_id":"23POSTCHF1022933","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8010877418","display_name":"Intrinsic and non-cell autonomous regulation of the SMC epigenetic clock","funder_award_id":"23CSA1051139","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8799238577","display_name":"Mechanisms of reverse vascular remodeling in pulmonary hypertension","funder_award_id":"19EIA34660321","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G9000866368","display_name":"Novel vascular smooth muscle cell progenitors in development and disease","funder_award_id":"R35HL150766","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000868462","display_name":"Sphingolipid signaling in age-associated vascular pathology","funder_award_id":"R01AG078602","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000871674","display_name":"Sphingosine kinase 1 plays a key role in defective elastin-induced arterial hypermuscularization","funder_award_id":"R00HL171838","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000872968","display_name":"Epigenetic-mediated Notch pathway activation promotes elastin aortopathy","funder_award_id":"R01HD110059","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1493876748","https://openalex.org/W1500209682","https://openalex.org/W1653019055","https://openalex.org/W1834434186","https://openalex.org/W1964939337","https://openalex.org/W1973096186","https://openalex.org/W1977189130","https://openalex.org/W1991155818","https://openalex.org/W1991525905","https://openalex.org/W1998486974","https://openalex.org/W2005244540","https://openalex.org/W2012047843","https://openalex.org/W2013293473","https://openalex.org/W2013762859","https://openalex.org/W2016087648","https://openalex.org/W2034209061","https://openalex.org/W2036505292","https://openalex.org/W2036704843","https://openalex.org/W2037394705","https://openalex.org/W2040286355","https://openalex.org/W2062851886","https://openalex.org/W2063072875","https://openalex.org/W2064792916","https://openalex.org/W2083008324","https://openalex.org/W2084756176","https://openalex.org/W2106040829","https://openalex.org/W2107676840","https://openalex.org/W2110388058","https://openalex.org/W2110727116","https://openalex.org/W2118522871","https://openalex.org/W2122563088","https://openalex.org/W2125788704","https://openalex.org/W2131653261","https://openalex.org/W2132478456","https://openalex.org/W2138946261","https://openalex.org/W2143068056","https://openalex.org/W2144535813","https://openalex.org/W2149902537","https://openalex.org/W2153643012","https://openalex.org/W2159683825","https://openalex.org/W2166792528","https://openalex.org/W2166957348","https://openalex.org/W2171122293","https://openalex.org/W2282752390","https://openalex.org/W2296848231","https://openalex.org/W2320649507","https://openalex.org/W2337592013","https://openalex.org/W2346331532","https://openalex.org/W2416456847","https://openalex.org/W2594216518","https://openalex.org/W2617133458","https://openalex.org/W2746133014","https://openalex.org/W2767130865","https://openalex.org/W2767580649","https://openalex.org/W2800894548","https://openalex.org/W2889205449","https://openalex.org/W2896977034","https://openalex.org/W2900747116","https://openalex.org/W2912610296","https://openalex.org/W2979539797","https://openalex.org/W2981063663","https://openalex.org/W2995120520","https://openalex.org/W3007651425","https://openalex.org/W3012006264","https://openalex.org/W3037181123","https://openalex.org/W3041366450","https://openalex.org/W3043992017","https://openalex.org/W3112931142","https://openalex.org/W3150453735","https://openalex.org/W3154072271","https://openalex.org/W3159287587","https://openalex.org/W3206271968","https://openalex.org/W4205838182","https://openalex.org/W4211265573","https://openalex.org/W4220955450","https://openalex.org/W4281780620","https://openalex.org/W4285596431","https://openalex.org/W4296458549","https://openalex.org/W4309570506","https://openalex.org/W4310860992","https://openalex.org/W4375952462","https://openalex.org/W4389670585","https://openalex.org/W4403611539"],"related_works":["https://openalex.org/W4404324119","https://openalex.org/W4411543869","https://openalex.org/W7118159018","https://openalex.org/W4389670585","https://openalex.org/W4366088966","https://openalex.org/W4205838182","https://openalex.org/W4389953506","https://openalex.org/W2064792916","https://openalex.org/W2296848231","https://openalex.org/W2142207826"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-01-05T00:00:00"}