{"id":"https://openalex.org/W7118095751","doi":"https://doi.org/10.1016/j.bioadv.2025.214701","title":"Functional replacement of fetal bovine serum by extracts from Galdieria sulphuraria in muscle cell culture","display_name":"Functional replacement of fetal bovine serum by extracts from Galdieria sulphuraria in muscle cell culture","publication_year":2026,"publication_date":"2026-01-02","ids":{"openalex":"https://openalex.org/W7118095751","doi":"https://doi.org/10.1016/j.bioadv.2025.214701","pmid":"https://pubmed.ncbi.nlm.nih.gov/41512468"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioadv.2025.214701","doi":"https://doi.org/10.1016/j.bioadv.2025.214701","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bioadv.2025.214701","pdf_url":null,"source":{"id":"https://openalex.org/S4210239156","display_name":"Biomaterials Advances","issn_l":"2772-9508","issn":["2772-9508","2772-9516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bioadv.2025.214701","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117502105","display_name":"Svenja H\u00fctker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091436","display_name":"Hochschule Bremerhaven","ror":"https://ror.org/001yqrb02","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210091436"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Svenja H\u00fctker","raw_affiliation_strings":["Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany","institution_ids":["https://openalex.org/I4210091436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121863225","display_name":"Hanna Wellkamp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091436","display_name":"Hochschule Bremerhaven","ror":"https://ror.org/001yqrb02","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210091436"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hanna Wellkamp","raw_affiliation_strings":["Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany","institution_ids":["https://openalex.org/I4210091436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038436470","display_name":"Verena Tellstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Verena Tellstroem","raw_affiliation_strings":["Bruker Daltonics GmbH & Co. KG, Fahrenheitstr. 4, 28359 Bremen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bruker Daltonics GmbH & Co. KG, Fahrenheitstr. 4, 28359 Bremen, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019501077","display_name":"Imke Lang","orcid":"https://orcid.org/0000-0002-5402-461X","observed_orcids":["https://orcid.org/0000-0002-5402-461X"]},"institutions":[{"id":"https://openalex.org/I4210091436","display_name":"Hochschule Bremerhaven","ror":"https://ror.org/001yqrb02","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210091436"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Imke Lang","raw_affiliation_strings":["Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany","institution_ids":["https://openalex.org/I4210091436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023903293","display_name":"Felicitas Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091436","display_name":"Hochschule Bremerhaven","ror":"https://ror.org/001yqrb02","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210091436"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Felicitas Berger","raw_affiliation_strings":["Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany. Electronic address: fberger@hs-bremerhaven.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bremerhaven University of Applied Sciences, Institute EcoMaterials, An der Karlstadt 8, 27568 Bremerhaven, Germany. Electronic address: fberger@hs-bremerhaven.de","institution_ids":["https://openalex.org/I4210091436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023903293"],"corresponding_institution_ids":["https://openalex.org/I4210091436"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":{"value":3750,"currency":"USD","value_usd":3750},"fwci":5.2095,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.94699786,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"182","issue":null,"first_page":"214701","last_page":"214701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.8090999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.06949999928474426,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galdieria-sulphuraria","display_name":"Galdieria sulphuraria","score":0.9649999737739563},{"id":"https://openalex.org/keywords/serum-free-culture","display_name":"serum-free culture","score":0.6330000162124634},{"id":"https://openalex.org/keywords/fetal-bovine-serum-replacement","display_name":"fetal bovine serum replacement","score":0.9929999709129333},{"id":"https://openalex.org/keywords/myoblast-proliferation","display_name":"myoblast proliferation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cultured-meat","display_name":"cultured meat","score":0.7379999756813049},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.8999999761581421},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C2779404806","wikidata":"https://www.wikidata.org/wiki/Q488614","display_name":"Fetal bovine serum","level":3,"score":0.7925999760627747},{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.7853999733924866},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.6759999990463257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6412000060081482},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.6089000105857849},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5993000268936157},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5728999972343445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4993000030517578},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4668999910354614},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.43149998784065247},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4309000074863434},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4212000072002411},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C98648569","wikidata":"https://www.wikidata.org/wiki/Q5090513","display_name":"Chemically defined medium","level":3,"score":0.3499999940395355},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.32510000467300415},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2809999883174896},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.26330000162124634}],"mesh":[{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D044967","descriptor_name":"Serum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bioadv.2025.214701","doi":"https://doi.org/10.1016/j.bioadv.2025.214701","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bioadv.2025.214701","pdf_url":null,"source":{"id":"https://openalex.org/S4210239156","display_name":"Biomaterials Advances","issn_l":"2772-9508","issn":["2772-9508","2772-9516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Advances","raw_type":"journal-article"},{"id":"pmid:41512468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41512468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bioadv.2025.214701","doi":"https://doi.org/10.1016/j.bioadv.2025.214701","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bioadv.2025.214701","pdf_url":null,"source":{"id":"https://openalex.org/S4210239156","display_name":"Biomaterials Advances","issn_l":"2772-9508","issn":["2772-9508","2772-9516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1983325133","https://openalex.org/W2012991711","https://openalex.org/W2057796930","https://openalex.org/W2083405476","https://openalex.org/W2128635872","https://openalex.org/W2134783492","https://openalex.org/W2332797918","https://openalex.org/W2885192444","https://openalex.org/W3171820197","https://openalex.org/W3177009627","https://openalex.org/W4205627420","https://openalex.org/W4206629829","https://openalex.org/W4206980534","https://openalex.org/W4281755890","https://openalex.org/W4315482325","https://openalex.org/W4360615145","https://openalex.org/W4382559755","https://openalex.org/W4387327933","https://openalex.org/W4388905749","https://openalex.org/W4392649853","https://openalex.org/W4399896860","https://openalex.org/W4404297474","https://openalex.org/W4404638582","https://openalex.org/W4405659890","https://openalex.org/W4410258642","https://openalex.org/W4414351156","https://openalex.org/W4415680688"],"related_works":["https://openalex.org/W4410258642","https://openalex.org/W7131356553","https://openalex.org/W4407764599","https://openalex.org/W7008073178","https://openalex.org/W7126220830","https://openalex.org/W4404638582","https://openalex.org/W4402404295","https://openalex.org/W4315482325","https://openalex.org/W4319595044","https://openalex.org/W7062300986"],"abstract_inverted_index":{"The":[0,92],"development":[1],"of":[2,14,27,73,94,139],"serum-free":[3,114],"culture":[4,224],"systems":[5],"is":[6],"a":[7,213],"major":[8],"challenge":[9],"in":[10,37,221],"the":[11,25,34,53,60,156],"large-scale":[12],"production":[13],"cultured":[15],"meat,":[16],"where":[17],"myoblasts":[18],"must":[19],"be":[20],"expanded":[21],"and":[22,45,71,86,104,113,122,128,154,175,204,215],"differentiated":[23],"without":[24],"use":[26],"fetal":[28],"bovine":[29],"serum":[30],"(FBS).":[31],"FBS":[32,68,140],"remains":[33],"gold":[35],"standard":[36],"myoblast":[38,147,202],"culture,":[39],"yet":[40],"it":[41],"poses":[42],"ethical,":[43],"economic,":[44],"environmental":[46],"concerns.":[47],"In":[48],"this":[49],"study,":[50],"we":[51],"tested":[52],"hypothesis,":[54],"that":[55,179,194],"protein-rich":[56],"extracts":[57,82,96,117,124,144,198],"derived":[58],"from":[59],"red":[61],"microalga":[62],"Galdieria":[63],"sulphuraria":[64],"can":[65,199],"functionally":[66],"replace":[67],"during":[69,131],"proliferation":[70,102,152,203],"differentiation":[72,107,159,205],"murine":[74],"C2C12":[75],"skeletal":[76],"muscle":[77,222],"myoblasts.":[78],"Native":[79],"algal":[80,143],"protein":[81,171,188,197],"were":[83,108],"prepared,":[84],"heat-treated,":[85],"fractionated":[87,123],"by":[88],"ammonium":[89],"sulfate":[90],"precipitation.":[91],"effects":[93],"these":[95,191],"on":[97],"cell":[98,126,223],"viability,":[99],"metabolic":[100,129],"activity,":[101],"kinetics":[103],"terminal":[105],"myogenic":[106],"systematically":[109],"assessed":[110],"under":[111],"serum-reduced":[112],"conditions.":[115],"Crude":[116],"exhibited":[118],"cytotoxicity,":[119],"whereas":[120],"heat-treated":[121,142,176],"enhanced":[125],"viability":[127],"activity":[130],"short-term":[132],"culture.":[133],"During":[134],"long-term":[135,201],"cultivation,":[136],"gradual":[137],"replacement":[138],"with":[141,150],"supported":[145],"sustained":[146],"growth,":[148],"albeit":[149],"reduced":[151],"rates,":[153],"preserved":[155],"capacity":[157],"for":[158],"into":[160],"multinucleated,":[161],"myosin":[162],"heavy":[163],"chain-positive":[164],"myotubes.":[165],"Comparative":[166],"proteomic":[167],"analysis":[168],"revealed":[169],"distinct":[170],"profiles":[172],"between":[173],"crude":[174],"extracts,":[177],"suggesting":[178],"thermal":[180],"processing":[181],"removes":[182],"inhibitory":[183],"components":[184],"while":[185],"enriching":[186],"bioactive":[187],"fractions.":[189],"Collectively,":[190],"results":[192],"demonstrate":[193],"G.":[195],"sulphuraria-derived":[196],"support":[200],"following":[206],"appropriate":[207],"adaption,":[208],"highlighting":[209],"their":[210],"potential":[211],"as":[212],"sustainable":[214],"animal-free":[216],"alternative":[217],"to":[218],"serum-derived":[219],"supplements":[220],"systems.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-01-03T00:00:00"}
