{"id":"https://openalex.org/W7118011663","doi":"https://doi.org/10.1007/978-981-95-3628-3_9","title":"Combining CAR T Cells with Immunotherapies to Enhance Treatment Effectiveness","display_name":"Combining CAR T Cells with Immunotherapies to Enhance Treatment Effectiveness","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7118011663","doi":"https://doi.org/10.1007/978-981-95-3628-3_9"},"language":"en","primary_location":{"id":"doi:10.1007/978-981-95-3628-3_9","doi":"https://doi.org/10.1007/978-981-95-3628-3_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-981-95-3628-3_9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advancement in CAR T-Cell Therapy in Tumors","raw_type":"book-chapter"},"parent_works":[{"id":"https://openalex.org/W7118023093","display_name":"Advancement in CAR T-Cell Therapy in Tumors: Current Challenges and Future Directions","relationship":"volume"}],"lineage":["https://openalex.org/W7118011663","https://openalex.org/W7118023093"],"child_works_count":0,"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048878908","display_name":"Divya Chaudhary","orcid":"https://orcid.org/0000-0002-7704-0372","observed_orcids":["https://orcid.org/0000-0002-7704-0372"]},"institutions":[{"id":"https://openalex.org/I4405260680","display_name":"Noida Institute of Engineering and Technology Pharmacy Institute","ror":"https://ror.org/0444ywk33","country_code":"IN","type":"education","lineage":["https://openalex.org/I4405260680"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Divya Chaudhary","raw_affiliation_strings":["Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India","institution_ids":["https://openalex.org/I4405260680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121765516","display_name":"Manish Kushwaha","orcid":"https://orcid.org/0009-0004-3064-420X","observed_orcids":["https://orcid.org/0009-0004-3064-420X"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]},{"id":"https://openalex.org/I4389425506","display_name":"Mahatma Gandhi Central University","ror":"https://ror.org/013f9hb65","country_code":"IN","type":"education","lineage":["https://openalex.org/I4389425506"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manish Kushwaha","raw_affiliation_strings":["Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India","School of Life Science, Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]},{"raw_affiliation_string":"School of Life Science, Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, India","institution_ids":["https://openalex.org/I4389425506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121825461","display_name":"Alpana Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4389425506","display_name":"Mahatma Gandhi Central University","ror":"https://ror.org/013f9hb65","country_code":"IN","type":"education","lineage":["https://openalex.org/I4389425506"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Alpana Singh","raw_affiliation_strings":["School of Life Science, Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, India","institution_ids":["https://openalex.org/I4389425506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121471576","display_name":"Rishabh Chaudhary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143247161","display_name":"Babasaheb Bhimrao Ambedkar University","ror":"https://ror.org/04x7ccp17","country_code":"IN","type":"education","lineage":["https://openalex.org/I143247161"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rishabh Chaudhary","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India","institution_ids":["https://openalex.org/I143247161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068962458","display_name":"Payal Rana","orcid":"https://orcid.org/0000-0001-7147-4711","observed_orcids":["https://orcid.org/0000-0001-7147-4711","https://orcid.org/0009-0005-7137-889X"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Payal Rana","raw_affiliation_strings":["Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099148120","display_name":"Pallavi Khodlan","orcid":"https://orcid.org/0009-0001-1504-8926","observed_orcids":["https://orcid.org/0009-0001-1504-8926"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]},{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pallavi Khodlan","raw_affiliation_strings":["Department of Biotechnology, Jamia Millia Islamia (Central University), New Delhi, India","Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Jamia Millia Islamia (Central University), New Delhi, India","institution_ids":["https://openalex.org/I59475050"]},{"raw_affiliation_string":"Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026553618","display_name":"Anupam Teotia","orcid":"https://orcid.org/0009-0009-2331-0638","observed_orcids":["https://orcid.org/0009-0009-2331-0638"]},"institutions":[{"id":"https://openalex.org/I4210156726","display_name":"National Institute of Immunology","ror":"https://ror.org/04fhee747","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I4210156726"]},{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anupam Teotia","raw_affiliation_strings":["Department of Environmental Science, Jamia Millia Islamia (Central University), New Delhi, India","Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Science, Jamia Millia Islamia (Central University), New Delhi, India","institution_ids":["https://openalex.org/I59475050"]},{"raw_affiliation_string":"Gene Regulation Laboratory, National Institute of Immunology, New Delhi, India","institution_ids":["https://openalex.org/I4210156726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087473918","display_name":"Akhilesh Kumar Singh","orcid":"https://orcid.org/0000-0001-8670-3599","observed_orcids":["https://orcid.org/0000-0001-8670-3599"]},"institutions":[{"id":"https://openalex.org/I4389425506","display_name":"Mahatma Gandhi Central University","ror":"https://ror.org/013f9hb65","country_code":"IN","type":"education","lineage":["https://openalex.org/I4389425506"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akhilesh Kumar Singh","raw_affiliation_strings":["School of Life Science, Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science, Department of Biotechnology, Mahatma Gandhi Central University, Motihari, Bihar, India","institution_ids":["https://openalex.org/I4389425506"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rajeev Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajeev Singh","raw_affiliation_strings":["Department of Biotechnology, Jamia Millia Islamia (Central University), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Jamia Millia Islamia (Central University), New Delhi, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101787602","display_name":"Sadaf Fatima","orcid":"https://orcid.org/0000-0002-9955-4577","observed_orcids":["https://orcid.org/0000-0002-9955-4577","https://orcid.org/0000-0002-5614-4383"]},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sadaf Fatima","raw_affiliation_strings":["Department of Biotechnology, Jamia Millia Islamia (Central University), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Jamia Millia Islamia (Central University), New Delhi, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008659884","display_name":"Umesh Kumar","orcid":"https://orcid.org/0000-0002-4715-7967","observed_orcids":["https://orcid.org/0000-0002-4715-7967","https://orcid.org/0000-0001-5183-1742","https://orcid.org/0000-0003-3088-1163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Umesh Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5146930684","display_name":"Anil Kumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anil Kumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5146930684"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"241","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8849999904632568},{"id":"https://openalex.org/keywords/allogeneic-car-t-cells","display_name":"allogeneic CAR T cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.578000009059906},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6759999990463257},{"id":"https://openalex.org/keywords/anti-cd19-antibody","display_name":"anti-CD19","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8080000281333923},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.8363999724388123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6317999958992004},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5429999828338623},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5414999723434448},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46129998564720154},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4587000012397766},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.454800009727478},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4325999915599823},{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.42250001430511475},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4025999903678894},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.399399995803833},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.3822000026702881},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3779999911785126},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3691999912261963},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.33079999685287476},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.31310001015663147},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29580000042915344},{"id":"https://openalex.org/C2911194787","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"CAR T-cell therapy","level":5,"score":0.2922999858856201},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2793999910354614},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.27250000834465027},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C3019217517","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor associated antigen","level":4,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-981-95-3628-3_9","doi":"https://doi.org/10.1007/978-981-95-3628-3_9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-981-95-3628-3_9","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advancement in CAR T-Cell Therapy in Tumors","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1993971516","https://openalex.org/W2033278321","https://openalex.org/W2124513722","https://openalex.org/W2785852906","https://openalex.org/W2787301955","https://openalex.org/W2787621143","https://openalex.org/W2792588868","https://openalex.org/W2888063816","https://openalex.org/W2889295047","https://openalex.org/W2919051790","https://openalex.org/W2922471907","https://openalex.org/W2974984990","https://openalex.org/W2986629061","https://openalex.org/W2998352028","https://openalex.org/W3011816321","https://openalex.org/W3047076113","https://openalex.org/W3106753232","https://openalex.org/W3148729173","https://openalex.org/W3156569173","https://openalex.org/W3166162784","https://openalex.org/W3172144992","https://openalex.org/W4220841520","https://openalex.org/W4281724842","https://openalex.org/W4296299339","https://openalex.org/W4297540281","https://openalex.org/W4304807853","https://openalex.org/W4383105325","https://openalex.org/W4386967472","https://openalex.org/W4389092279","https://openalex.org/W4391404460","https://openalex.org/W4394617056","https://openalex.org/W4398142342","https://openalex.org/W4399466513","https://openalex.org/W4401284904","https://openalex.org/W4401372023","https://openalex.org/W4406033921","https://openalex.org/W4406229010","https://openalex.org/W4406722476","https://openalex.org/W4408883138","https://openalex.org/W4410420106"],"related_works":["https://openalex.org/W4387572340","https://openalex.org/W7199428988","https://openalex.org/W3135234497","https://openalex.org/W4389992017","https://openalex.org/W4383534104","https://openalex.org/W7080175327","https://openalex.org/W4405487487","https://openalex.org/W3217586139","https://openalex.org/W4297540281","https://openalex.org/W4415029011"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2026-01-02T00:00:00"}