{"id":"https://openalex.org/W7117486459","doi":"https://doi.org/10.1186/s12951-025-03976-w","title":"Microglia-specific interleukin-4 delivery by engineered extracellular vesicles restores inner blood-retinal barrier in diabetic retinopathy via GAS6-MERTK pathway","display_name":"Microglia-specific interleukin-4 delivery by engineered extracellular vesicles restores inner blood-retinal barrier in diabetic retinopathy via GAS6-MERTK pathway","publication_year":2025,"publication_date":"2025-12-29","ids":{"openalex":"https://openalex.org/W7117486459","doi":"https://doi.org/10.1186/s12951-025-03976-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/41462307","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12860109"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-025-03976-w","doi":"https://doi.org/10.1186/s12951-025-03976-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-025-03976-w","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12951-025-03976-w","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146562514","display_name":"Yuanyuan Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Fan","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041939894","display_name":"Pengfei Ge","orcid":"https://orcid.org/0009-0006-8736-3809","observed_orcids":["https://orcid.org/0009-0006-8736-3809"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Ge","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104292662","display_name":"Xingxing Wang","orcid":"https://orcid.org/0009-0004-4751-8058","observed_orcids":["https://orcid.org/0009-0004-4751-8058"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210108480","display_name":"Second Affiliated Hospital of Nanchang University","ror":"https://ror.org/01nxv5c88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingxing Wang","raw_affiliation_strings":["Department of Ophthalmology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210108480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121484718","display_name":"Jingyi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingyi Xu","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045653020","display_name":"Jingfan Wang","orcid":"https://orcid.org/0000-0003-3208-8281","observed_orcids":["https://orcid.org/0000-0003-3208-8281"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingfan Wang","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719240","display_name":"Hongying Li","orcid":"https://orcid.org/0000-0002-5089-1134","observed_orcids":["https://orcid.org/0000-0002-5089-1134"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongying Li","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009883598","display_name":"Qinyuan Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinyuan Gu","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014440236","display_name":"Haiyue Xie","orcid":"https://orcid.org/0000-0003-4982-7810","observed_orcids":["https://orcid.org/0000-0003-4982-7810"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyue Xie","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004002659","display_name":"Yifan Lin","orcid":"https://orcid.org/0000-0002-6967-8237","observed_orcids":["https://orcid.org/0000-0002-6967-8237"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Lin","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135893722","display_name":"Yangyang Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Lu","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010456925","display_name":"Chengkun Wang","orcid":"https://orcid.org/0000-0002-2505-7295","observed_orcids":["https://orcid.org/0000-0002-2505-7295"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengkun Wang","raw_affiliation_strings":["Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101286251","display_name":"Ping Xie","orcid":"https://orcid.org/0000-0002-0754-2959","observed_orcids":["https://orcid.org/0000-0002-0754-2959"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ping Xie","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. xieping9@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. xieping9@126.com","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073086360","display_name":"Zizhong Hu","orcid":"https://orcid.org/0000-0001-6289-1804","observed_orcids":["https://orcid.org/0000-0001-6289-1804"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zizhong Hu","raw_affiliation_strings":["Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. huzizhong@njmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. huzizhong@njmu.edu.cn","institution_ids":["https://openalex.org/I4210152119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073086360","https://openalex.org/A5101286251"],"corresponding_institution_ids":["https://openalex.org/I4210152119"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":1.5454,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80292275,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"24","issue":"1","first_page":"101","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.02449999935925007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8980000019073486},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9549999833106995},{"id":"https://openalex.org/keywords/blood-retinal-barrier","display_name":"blood-retinal barrier","score":0.7919999957084656},{"id":"https://openalex.org/keywords/m1-microglia","display_name":"M1 microglia","score":0.7070000171661377},{"id":"https://openalex.org/keywords/m2-microglia-polarization","display_name":"M2 microglia polarization","score":0.9070000052452087},{"id":"https://openalex.org/keywords/microglial-phagocytosis","display_name":"microglial phagocytosis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oxygen-induced-retinopathy","display_name":"oxygen-induced retinopathy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pathological-angiogenesis","display_name":"pathological angiogenesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pericyte-loss","display_name":"pericyte loss","score":0.6629999876022339},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6539000272750854},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.5738000273704529},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5471000075340271},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5389999747276306},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5368000268936157},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.4625999927520752},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.4456000030040741},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4214000105857849},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4117000102996826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.39169999957084656},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3865000009536743},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3154999911785126},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.31459999084472656},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.28290000557899475},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.26579999923706055},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.26260000467300415},{"id":"https://openalex.org/C2781188250","wikidata":"https://www.wikidata.org/wiki/Q4455440","display_name":"Therapeutic angiogenesis","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.25609999895095825},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.2531999945640564}],"mesh":[{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000067128","descriptor_name":"Extracellular Vesicles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001813","descriptor_name":"Blood-Retinal Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12951-025-03976-w","doi":"https://doi.org/10.1186/s12951-025-03976-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-025-03976-w","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12860109","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12860109/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12860109/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Nanobiotechnology","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11667720","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12860109","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41462307","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41462307","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nanobiotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ce1213411bcf4f399d0bcf5961aa97c0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ce1213411bcf4f399d0bcf5961aa97c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nanobiotechnology, Vol 24, Iss 1, Pp 1-22 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12951-025-03976-w","doi":"https://doi.org/10.1186/s12951-025-03976-w","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-025-03976-w","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3495289653","display_name":null,"funder_award_id":"82371076","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4493150663","display_name":null,"funder_award_id":"82471095","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320324291","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7117486459.pdf","grobid_xml":"https://content.openalex.org/works/W7117486459.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1555251831","https://openalex.org/W2045350680","https://openalex.org/W2057185572","https://openalex.org/W2059088148","https://openalex.org/W2069893872","https://openalex.org/W2094935740","https://openalex.org/W2120276758","https://openalex.org/W2130639482","https://openalex.org/W2193621263","https://openalex.org/W2228927093","https://openalex.org/W2587462790","https://openalex.org/W2970639874","https://openalex.org/W3003217963","https://openalex.org/W3010043225","https://openalex.org/W3013593135","https://openalex.org/W3014630476","https://openalex.org/W3022149510","https://openalex.org/W3045719999","https://openalex.org/W3047276656","https://openalex.org/W3092199218","https://openalex.org/W3092275309","https://openalex.org/W3106938124","https://openalex.org/W3113175786","https://openalex.org/W3134569360","https://openalex.org/W3150790735","https://openalex.org/W3154493503","https://openalex.org/W3155395389","https://openalex.org/W3158522809","https://openalex.org/W4212945288","https://openalex.org/W4221133084","https://openalex.org/W4225128938","https://openalex.org/W4285593846","https://openalex.org/W4293435091","https://openalex.org/W4293598549","https://openalex.org/W4294176574","https://openalex.org/W4306731659","https://openalex.org/W4363677540","https://openalex.org/W4379364297","https://openalex.org/W4388017465","https://openalex.org/W4389482566","https://openalex.org/W4391112831","https://openalex.org/W4391684183","https://openalex.org/W4393118184","https://openalex.org/W4393527209","https://openalex.org/W4397008788","https://openalex.org/W4402400759","https://openalex.org/W4403545279","https://openalex.org/W4408974333","https://openalex.org/W4409094549","https://openalex.org/W4410140399","https://openalex.org/W4410385525","https://openalex.org/W4410949640","https://openalex.org/W4412521222"],"related_works":["https://openalex.org/W4389952264","https://openalex.org/W4413318496","https://openalex.org/W4281483545","https://openalex.org/W4410435180","https://openalex.org/W4387701193","https://openalex.org/W4385397350","https://openalex.org/W4411865719","https://openalex.org/W7171693755","https://openalex.org/W4414390611","https://openalex.org/W4394594159"],"abstract_inverted_index":{"Maintaining":[0],"a":[1,134,178,182],"balanced":[2],"polarization":[3],"of":[4,8,37,63,72,78,126],"microglia":[5,157,176],"is":[6],"one":[7],"the":[9,33,70,76,153],"most":[10],"potential":[11,179],"therapeutic":[12],"approaches":[13],"for":[14,53,174,181],"diabetic":[15,131],"retinopathy":[16,113],"(DR).":[17],"However,":[18],"reliable,":[19],"sustained,":[20],"effective,":[21],"and":[22,35,47,85,103,109,115,123,151,158,171],"controllable":[23],"microglial":[24,141],"regulation":[25],"still":[26],"faces":[27],"formidable":[28],"challenges.":[29],"Here,":[30],"inspired":[31],"by":[32,107],"bioavailability":[34],"modifiability":[36],"extracellular":[38],"vesicles":[39],"(EV),":[40],"we":[41],"developed":[42],"an":[43,168],"interleukin":[44],"4":[45],"(IL4)-encapsulated":[46],"M1":[48],"microglia-targeting":[49],"EV":[50,166],"platform":[51],"(IL4@CHHSSSARC-EV)":[52],"rescuing":[54],"inner":[55],"blood-retina":[56],"barrier":[57],"(iBRB)":[58],"deterioration":[59],"in":[60,83,86,111,129,186],"DR.":[61,187],"Delivery":[62],"IL4":[64],"via":[65],"IL4@CHHSSSARC-EV":[66,98,139],"enhanced":[67],"not":[68],"only":[69],"stability":[71],"IL4,":[73],"but":[74],"also":[75],"efficacy":[77],"anti-inflammatory":[79],"phenotype":[80],"(M2)":[81],"shift":[82],"vitro":[84],"vivo":[87],"due":[88],"to":[89,92],"their":[90],"selectivity":[91],"pro-inflammatory":[93],"(M1)":[94],"microglia.":[95],"Treatment":[96],"with":[97,133],"significantly":[99],"ameliorated":[100],"pathological":[101,159],"angiogenesis":[102],"iBRB":[104],"breakdown":[105],"caused":[106],"hypoxia":[108],"ischemia":[110],"oxygen-induced":[112],"models,":[114],"potently":[116],"minimized":[117],"leakage,":[118],"bleeding,":[119],"lesions,":[120],"pericyte":[121],"loss":[122],"leukocyte":[124],"adherence":[125],"vascular":[127],"network":[128],"streptozotocin-induced":[130],"mice":[132],"high":[135],"safety":[136],"profile.":[137],"Mechanistically,":[138],"facilitated":[140],"phagocytic":[142],"capacity":[143],"through":[144],"GAS6-MERTK":[145],"signaling,":[146],"thereby":[147],"engulfing":[148],"aberrant":[149],"vessels":[150],"disrupting":[152],"reciprocal":[154],"crosstalk":[155],"between":[156],"vasculature.":[160],"Our":[161],"study":[162],"demonstrated":[163],"that":[164],"engineering":[165],"as":[167],"enduring,":[169],"efficient":[170],"safe":[172],"implement":[173],"manipulating":[175],"provided":[177],"strategy":[180],"rebalanced":[183],"immune":[184],"profile":[185]},"counts_by_year":[{"year":2026,"cited_by_count":7}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-12-29T00:00:00"}
