{"id":"https://openalex.org/W7117136455","doi":"https://doi.org/10.1038/s41467-025-67736-y","title":"Toward single-cell control: noise-robust perfect adaptation in biomolecular systems","display_name":"Toward single-cell control: noise-robust perfect adaptation in biomolecular systems","publication_year":2025,"publication_date":"2025-12-24","ids":{"openalex":"https://openalex.org/W7117136455","doi":"https://doi.org/10.1038/s41467-025-67736-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41444234"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-025-67736-y","doi":"https://doi.org/10.1038/s41467-025-67736-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-67736-y","pdf_url":"https://www.nature.com/articles/s41467-025-67736-y_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-025-67736-y_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018318482","display_name":"Dongju Lim","orcid":"https://orcid.org/0009-0007-5822-0646","observed_orcids":["https://orcid.org/0009-0007-5822-0646"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dongju Lim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210104335","https://openalex.org/I4210139925"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121180769","display_name":"Seokhwan Moon","orcid":"https://orcid.org/0009-0008-5852-1788","observed_orcids":["https://orcid.org/0009-0008-5852-1788"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Seokhwan Moon","raw_affiliation_strings":["Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea","Department of Mathematics, University of Wisconsin-Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0009-0008-5852-1788","affiliations":[{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Mathematics, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101620491","display_name":"Yun Min Song","orcid":"https://orcid.org/0000-0001-7562-5935","observed_orcids":["https://orcid.org/0000-0001-7562-5935"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]},{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun Min Song","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7562-5935","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210104335","https://openalex.org/I4210139925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020140145","display_name":"Minjun Kim","orcid":"https://orcid.org/0000-0001-9539-9613","observed_orcids":["https://orcid.org/0000-0001-9539-9613"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minjun Kim","raw_affiliation_strings":["Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea","institution_ids":["https://openalex.org/I123900574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020901992","display_name":"J.-H. Kim","orcid":"https://orcid.org/0009-0001-2321-9174","observed_orcids":["https://orcid.org/0009-0001-2321-9174"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinyeong Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103277046","display_name":"Kangsan Kim","orcid":"https://orcid.org/0000-0001-6883-1124","observed_orcids":["https://orcid.org/0000-0001-6883-1124"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinyeong Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103277046","display_name":"Kangsan Kim","orcid":"https://orcid.org/0000-0001-6883-1124","observed_orcids":["https://orcid.org/0000-0001-6883-1124"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kangsan Kim","raw_affiliation_strings":["Department of Biological Sciences, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091067470","display_name":"Byung\u2010Kwan Cho","orcid":"https://orcid.org/0000-0003-4788-4184","observed_orcids":["https://orcid.org/0000-0003-4788-4184"]},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Kwan Cho","raw_affiliation_strings":["Department of Biological Sciences, KAIST, Daejeon, Republic of Korea","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-4788-4184","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067034493","display_name":"Jae Kyoung Kim","orcid":"https://orcid.org/0000-0001-7842-2172","observed_orcids":["https://orcid.org/0000-0001-7842-2172"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jinsu Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9278-0881","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100746301","display_name":"Jinsu Kim","orcid":"https://orcid.org/0000-0001-9278-0881","observed_orcids":["https://orcid.org/0000-0001-9278-0881"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinsu Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-9278-0881","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147058477","display_name":"Jae Kyoung Kim","orcid":"https://orcid.org/0000-0001-7842-2172","observed_orcids":["https://orcid.org/0000-0001-7842-2172"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Kyoung Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7842-2172","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5147058477","display_name":"Jae Kyoung Kim","orcid":"https://orcid.org/0000-0001-7842-2172","observed_orcids":["https://orcid.org/0000-0001-7842-2172"]},"institutions":[{"id":"https://openalex.org/I123900574","display_name":"Pohang University of Science and Technology","ror":"https://ror.org/04xysgw12","country_code":"KR","type":"education","lineage":["https://openalex.org/I123900574"]},{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Kyoung Kim","raw_affiliation_strings":["Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","KI for the BioCentury, KAIST, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7842-2172","affiliations":[{"raw_affiliation_string":"Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I4210104335"]},{"raw_affiliation_string":"Department of Mathematical Sciences, KAIST, Daejeon, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Department of Mathematics, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. jinsukim@postech.ac.kr","institution_ids":["https://openalex.org/I123900574"]},{"raw_affiliation_string":"Department of Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. jaekkim@kaist.ac.kr","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Graduate School of Engineering Biology, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"KI for the BioCentury, KAIST, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5020901992","https://openalex.org/A5100746301","https://openalex.org/A5147058477"],"corresponding_institution_ids":["https://openalex.org/I123900574","https://openalex.org/I157485424","https://openalex.org/I197347611","https://openalex.org/I4210104335"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33153735,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"1","first_page":"1001","last_page":"1001"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11513","display_name":"stochastic dynamics and bifurcation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimerization","display_name":"dimerization","score":0.6129999756813049},{"id":"https://openalex.org/keywords/fano-factor","display_name":"Fano factor","score":0.9580000042915344},{"id":"https://openalex.org/keywords/intrinsic-noise","display_name":"intrinsic noise","score":0.7639999985694885},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.6129999756813049},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9750000238418579},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9639999866485596},{"id":"https://openalex.org/keywords/biomolecular-circuits","display_name":"biomolecular circuits","score":0.5339999794960022},{"id":"https://openalex.org/keywords/ergodicity","display_name":"ergodicity","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.7716000080108643},{"id":"https://openalex.org/C203479927","wikidata":"https://www.wikidata.org/wiki/Q5165939","display_name":"Controller (irrigation)","level":2,"score":0.6862999796867371},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.6743000149726868},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5807999968528748},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4138999879360199},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.3828999996185303},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C161362739","wikidata":"https://www.wikidata.org/wiki/Q2301555","display_name":"Open-loop controller","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C157524613","wikidata":"https://www.wikidata.org/wiki/Q2828883","display_name":"Fine-tuning","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C77553402","wikidata":"https://www.wikidata.org/wiki/Q13222579","display_name":"Upper and lower bounds","level":2,"score":0.29670000076293945},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C177454536","wikidata":"https://www.wikidata.org/wiki/Q578290","display_name":"Emphasis (telecommunications)","level":2,"score":0.2736999988555908},{"id":"https://openalex.org/C31814641","wikidata":"https://www.wikidata.org/wiki/Q638874","display_name":"Fano factor","level":4,"score":0.2721000015735626},{"id":"https://openalex.org/C107464732","wikidata":"https://www.wikidata.org/wiki/Q235781","display_name":"Adaptive control","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C29265498","wikidata":"https://www.wikidata.org/wiki/Q7047719","display_name":"Noise measurement","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C17500928","wikidata":"https://www.wikidata.org/wiki/Q959968","display_name":"Control system","level":2,"score":0.25429999828338623}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-025-67736-y","doi":"https://doi.org/10.1038/s41467-025-67736-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-67736-y","pdf_url":"https://www.nature.com/articles/s41467-025-67736-y_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2025.10.20.683581","doi":"https://doi.org/10.1101/2025.10.20.683581","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.20.683581","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/21/2025.10.20.683581.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41444234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41444234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11657416","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12848118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:dff5366dc89547f5bbf08785cd68752a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dff5366dc89547f5bbf08785cd68752a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 17, Iss 1, Pp 1-13 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12848118","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12848118/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41467-025-67736-y","doi":"https://doi.org/10.1038/s41467-025-67736-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-025-67736-y","pdf_url":"https://www.nature.com/articles/s41467-025-67736-y_reference.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1010832933","display_name":null,"funder_award_id":"RS-2023-00219980","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G1030985991","display_name":null,"funder_award_id":"2022R1C1C1008491","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G1108637520","display_name":null,"funder_award_id":"RS-2024-00406488","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"},{"id":"https://openalex.org/G1320125359","display_name":null,"funder_award_id":"RS-2023-00219980","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2475630667","display_name":null,"funder_award_id":"2021R1A6A1A10042944","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G3668238217","display_name":null,"funder_award_id":"RS-2021-NR056566","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4530446346","display_name":null,"funder_award_id":"2021R1A6A1A10042944","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"},{"id":"https://openalex.org/G482713564","display_name":null,"funder_award_id":"IBS-R029-C3","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"},{"id":"https://openalex.org/G6213748292","display_name":null,"funder_award_id":"RS-2021-NR056566","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G6685005352","display_name":null,"funder_award_id":"2021R1A6A1A10042944","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G8244411672","display_name":null,"funder_award_id":"2022Q019","funder_id":"https://openalex.org/F4320332195","funder_display_name":"Samsung"},{"id":"https://openalex.org/G8850967928","display_name":null,"funder_award_id":"R029-C3","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"},{"id":"https://openalex.org/G8959201914","display_name":null,"funder_award_id":"IO230407-05812-01","funder_id":"https://openalex.org/F4320332195","funder_display_name":"Samsung"},{"id":"https://openalex.org/G974365529","display_name":null,"funder_award_id":"SSTF-BA1902-01","funder_id":"https://openalex.org/F4320328437","funder_display_name":"Samsung Science and Technology Foundation"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320326441","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"},{"id":"https://openalex.org/F4320328437","display_name":"Samsung Science and Technology Foundation","ror":"https://ror.org/00gjmje40"},{"id":"https://openalex.org/F4320332195","display_name":"Samsung","ror":"https://ror.org/04w3jy968"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7117136455.pdf","grobid_xml":"https://content.openalex.org/works/W7117136455.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1965305472","https://openalex.org/W1984429906","https://openalex.org/W2001969368","https://openalex.org/W2007051223","https://openalex.org/W2019835759","https://openalex.org/W2021625708","https://openalex.org/W2053460598","https://openalex.org/W2063052296","https://openalex.org/W2076367743","https://openalex.org/W2095690101","https://openalex.org/W2115354930","https://openalex.org/W2123973944","https://openalex.org/W2133254839","https://openalex.org/W2247294682","https://openalex.org/W2276582555","https://openalex.org/W2295524060","https://openalex.org/W2330875406","https://openalex.org/W2802169056","https://openalex.org/W2802389030","https://openalex.org/W2808037978","https://openalex.org/W2895157742","https://openalex.org/W2950798121","https://openalex.org/W2951169596","https://openalex.org/W2952738056","https://openalex.org/W2995579925","https://openalex.org/W3082998071","https://openalex.org/W3136917260","https://openalex.org/W3150457959","https://openalex.org/W3169086554","https://openalex.org/W3193780421","https://openalex.org/W4226069241","https://openalex.org/W4248785858","https://openalex.org/W4306750716","https://openalex.org/W4384460990","https://openalex.org/W4386590161","https://openalex.org/W4401724310","https://openalex.org/W7106305783"],"related_works":[],"abstract_inverted_index":{"Robust":[0],"perfect":[1],"adaptation":[2],"(RPA),":[3],"whereby":[4],"a":[5,13,16,81,146,151,186,231],"consistent":[6],"output":[7,55,65,73,99,105,118,143],"level":[8,32,60,74,237],"is":[9,15,88,180],"maintained":[10,116],"even":[11,128],"after":[12,129],"disturbance,":[14],"highly":[17],"desired":[18,147],"feature":[19],"in":[20,166],"biological":[21,167,228],"systems.":[22,168],"This":[23],"property":[24],"can":[25],"be":[26],"achieved":[27],"at":[28,124],"the":[29,35,43,47,51,54,58,63,68,84,91,98,102,112,130,142,158,177,197,201,210,217,224],"population":[30],"average":[31],"by":[33,90,96,195],"combining":[34,196],"well-known":[36],"antithetic":[37],"integral":[38],"feedback":[39],"(AIF)":[40],"loop":[41,93],"into":[42],"target":[44,148],"network.":[45],"However,":[46],"AIF":[48,92,113],"controller":[49,110,114,139,171,199],"amplifies":[50],"noise":[52,85,109,119,134,138,144,165,198],"of":[53,62,71,104,163,189,205,212,226],"level,":[56,127],"disrupting":[57],"single-cell":[59,236],"regulation":[61,82],"system":[64,117,179,204],"and":[66],"compromising":[67],"conceptual":[69],"goal":[70],"stable":[72],"control.":[75],"To":[76],"address":[77],"this,":[78],"we":[79],"introduce":[80],"motif,":[83],"controller,":[86],"which":[87,208],"inspired":[89],"but":[94],"differs":[95],"sensing":[97],"levels":[100],"through":[101],"dimerization":[103],"species.":[106],"Combining":[107],"this":[108],"with":[111,200],"successfully":[115],"as":[120,122,154,156,174,176],"well":[121],"mean":[123],"their":[125],"original":[126],"perturbation,":[131],"thereby":[132],"achieving":[133,150,235],"RPA.":[135],"Furthermore,":[136],"our":[137,170],"could":[140],"reduce":[141],"to":[145,185,215],"value,":[149],"Fano":[152],"factor":[153],"small":[155],"1,":[157],"commonly":[159],"recognized":[160],"lower":[161],"bound":[162],"intrinsic":[164],"Notably,":[169],"remains":[172],"effective":[173],"long":[175],"combined":[178],"ergodic,":[181],"making":[182],"it":[183],"applicable":[184],"broad":[187],"range":[188],"networks.":[190],"We":[191],"demonstrate":[192],"its":[193],"utility":[194],"DNA":[202,218],"repair":[203],"Escherichia":[206],"coli,":[207],"reduced":[209],"proportion":[211],"cells":[213],"failing":[214],"initiate":[216],"damage":[219],"response.":[220],"These":[221],"findings":[222],"enhance":[223],"precision":[225],"existing":[227],"controllers,":[229],"marking":[230],"key":[232],"step":[233],"toward":[234],"regulation.":[238]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-12-24T00:00:00"}
