{"id":"https://openalex.org/W7117123723","doi":"https://doi.org/10.3390/v18010029","title":"The Role of mTOR Inhibitors in COVID-19 Outcomes Among Heart Transplant Recipients","display_name":"The Role of mTOR Inhibitors in COVID-19 Outcomes Among Heart Transplant Recipients","publication_year":2025,"publication_date":"2025-12-24","ids":{"openalex":"https://openalex.org/W7117123723","doi":"https://doi.org/10.3390/v18010029","pmid":"https://pubmed.ncbi.nlm.nih.gov/41600794"},"language":"en","primary_location":{"id":"doi:10.3390/v18010029","doi":"https://doi.org/10.3390/v18010029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v18010029","pdf_url":"https://www.mdpi.com/1999-4915/18/1/29/pdf?version=1766564428","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4915/18/1/29/pdf?version=1766564428","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034006100","display_name":"Agnieszka Anna Kuczaj","orcid":"https://orcid.org/0000-0002-9462-0467","observed_orcids":["https://orcid.org/0000-0002-9462-0467"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]},{"id":"https://openalex.org/I4210133622","display_name":"Silesian Center for Heart Disease","ror":"https://ror.org/04kn0zf27","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4210133622"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Agnieszka Kuczaj","raw_affiliation_strings":["Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418","https://openalex.org/I4210133622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022296708","display_name":"Szymon Warwas","orcid":"https://orcid.org/0000-0001-9930-5864","observed_orcids":["https://orcid.org/0000-0001-9930-5864"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]},{"id":"https://openalex.org/I4210133622","display_name":"Silesian Center for Heart Disease","ror":"https://ror.org/04kn0zf27","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4210133622"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Szymon Warwas","raw_affiliation_strings":["Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":"https://orcid.org/0000-0001-9930-5864","affiliations":[{"raw_affiliation_string":"Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418","https://openalex.org/I4210133622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121240913","display_name":"Miko\u0142aj Tyrka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Miko\u0142aj Tyrka","raw_affiliation_strings":["Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121190975","display_name":"B\u0142a\u017cej Skotnicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"B\u0142a\u017cej Skotnicki","raw_affiliation_strings":["Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121226056","display_name":"Daniel Szymecki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Daniel Szymecki","raw_affiliation_strings":["Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121140058","display_name":"Oliwia Jewu\u0142a","orcid":"https://orcid.org/0009-0004-4340-5902","observed_orcids":["https://orcid.org/0009-0004-4340-5902"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Oliwia Jewu\u0142a","raw_affiliation_strings":["Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":"https://orcid.org/0009-0004-4340-5902","affiliations":[{"raw_affiliation_string":"Students\u2019 Scientific Association, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019539597","display_name":"Szymon Pawlak","orcid":"https://orcid.org/0000-0001-9347-9839","observed_orcids":["https://orcid.org/0000-0001-9347-9839"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]},{"id":"https://openalex.org/I4210133622","display_name":"Silesian Center for Heart Disease","ror":"https://ror.org/04kn0zf27","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4210133622"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Szymon Pawlak","raw_affiliation_strings":["Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418","https://openalex.org/I4210133622"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002371458","display_name":"Piotr Przyby\u0142owski","orcid":"https://orcid.org/0000-0002-8114-3219","observed_orcids":["https://orcid.org/0000-0002-8114-3219"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]},{"id":"https://openalex.org/I4210133622","display_name":"Silesian Center for Heart Disease","ror":"https://ror.org/04kn0zf27","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4210133622"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Przyby\u0142owski","raw_affiliation_strings":["Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418","https://openalex.org/I4210133622"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064327586","display_name":"Tomasz Hrapkowicz","orcid":"https://orcid.org/0000-0002-8945-7351","observed_orcids":["https://orcid.org/0000-0002-8945-7351"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]},{"id":"https://openalex.org/I4210133622","display_name":"Silesian Center for Heart Disease","ror":"https://ror.org/04kn0zf27","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4210133622"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Tomasz Hrapkowicz","raw_affiliation_strings":["Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland"],"raw_orcid":"https://orcid.org/0000-0002-8945-7351","affiliations":[{"raw_affiliation_string":"Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, M.C. Sk\u0142odowskiej 9, 41-800 Zabrze, Poland","institution_ids":["https://openalex.org/I166182418","https://openalex.org/I4210133622"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034006100"],"corresponding_institution_ids":["https://openalex.org/I166182418","https://openalex.org/I4210133622"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56826363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"1","first_page":"29","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9200000166893005},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.8149999976158142},{"id":"https://openalex.org/keywords/calcineurin-inhibitors","display_name":"calcineurin inhibitors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/covid-19-mortality","display_name":"COVID-19 mortality","score":0.8149999976158142},{"id":"https://openalex.org/keywords/transplant-recipients","display_name":"transplant recipients","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8702999949455261},{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.8288999795913696},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.777400016784668},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7016000151634216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5116999745368958},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42590001225471497},{"id":"https://openalex.org/C2777921159","wikidata":"https://www.wikidata.org/wiki/Q32089","display_name":"Sirolimus","level":2,"score":0.4235999882221222},{"id":"https://openalex.org/C2778849806","wikidata":"https://www.wikidata.org/wiki/Q643396","display_name":"Heart transplantation","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.31679999828338623},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.3077999949455261},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28439998626708984},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2815000116825104},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.2565000057220459}],"mesh":[{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000091203","descriptor_name":"MTOR Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000091203","descriptor_name":"MTOR Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000091203","descriptor_name":"MTOR Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000091203","descriptor_name":"MTOR Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016027","descriptor_name":"Heart Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D065095","descriptor_name":"Calcineurin Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D065095","descriptor_name":"Calcineurin Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D065095","descriptor_name":"Calcineurin Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D065095","descriptor_name":"Calcineurin Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/v18010029","doi":"https://doi.org/10.3390/v18010029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v18010029","pdf_url":"https://www.mdpi.com/1999-4915/18/1/29/pdf?version=1766564428","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"pmid:41600794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41600794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:56ea0cdc5cc5444b872b9db91e0c9f53","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/56ea0cdc5cc5444b872b9db91e0c9f53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 18, Iss 1, p 29 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12846580","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12846580/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmh:oai:ruj.uj.edu.pl:item/573394","doi":null,"is_oa":true,"landing_page_url":"https://www.mdpi.com/1999-4915/18/1/29","pdf_url":null,"source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/v18010029","doi":"https://doi.org/10.3390/v18010029","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v18010029","pdf_url":"https://www.mdpi.com/1999-4915/18/1/29/pdf?version=1766564428","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8019194006919861,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328948","display_name":"Uniwersytet \u015al\u0105ski w Katowicach","ror":"https://ror.org/0104rcc94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7117123723.pdf","grobid_xml":"https://content.openalex.org/works/W7117123723.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1970842110","https://openalex.org/W1971655915","https://openalex.org/W1974973339","https://openalex.org/W1975050309","https://openalex.org/W1996058320","https://openalex.org/W1997472169","https://openalex.org/W2011384694","https://openalex.org/W2028292318","https://openalex.org/W2033930952","https://openalex.org/W2052741482","https://openalex.org/W2085191451","https://openalex.org/W2087667264","https://openalex.org/W2110636597","https://openalex.org/W2136728678","https://openalex.org/W2678437470","https://openalex.org/W2734455150","https://openalex.org/W3009859788","https://openalex.org/W3011014170","https://openalex.org/W3014281964","https://openalex.org/W3024750564","https://openalex.org/W3030878365","https://openalex.org/W3045252049","https://openalex.org/W3090452892","https://openalex.org/W3093849203","https://openalex.org/W3110875071","https://openalex.org/W3123471531","https://openalex.org/W3136337343","https://openalex.org/W3206849090","https://openalex.org/W3209312878","https://openalex.org/W3212946110","https://openalex.org/W4283213704","https://openalex.org/W4283315337","https://openalex.org/W4283698599","https://openalex.org/W4293171083","https://openalex.org/W4293513742","https://openalex.org/W4313207390","https://openalex.org/W4365145728","https://openalex.org/W4376636213","https://openalex.org/W4387341102","https://openalex.org/W4406677638","https://openalex.org/W4410613009","https://openalex.org/W4413804311","https://openalex.org/W4416252769"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Heart":[1],"failure":[2],"(HF)":[3],"remains":[4],"a":[5],"major":[6],"global":[7],"health":[8],"challenge,":[9],"with":[10,138,175],"orthotopic":[11,115],"heart":[12,92,116],"transplantation":[13],"(OHT)":[14],"serving":[15],"as":[16],"the":[17,31,41,82,157,185,198,207],"gold-standard":[18],"therapy":[19,97,218],"for":[20,219],"end-stage":[21],"disease.":[22],"Chronic":[23],"immunosuppression":[24,213],"required":[25],"to":[26,47,104,129,216],"prevent":[27],"graft":[28],"rejection":[29],"increases":[30],"risk":[32],"of":[33,44,84,169,224],"infections":[34],"and":[35,71,152,178,190],"malignancies.":[36],"The":[37,222],"COVID-19":[38,89,220],"pandemic":[39],"underscored":[40],"particular":[42],"vulnerability":[43],"transplant":[45,93,117],"recipients":[46,118],"severe":[48],"SARS-CoV-2":[49,61],"infection.":[50,62],"Specific":[51],"immunosuppressive":[52,85],"agents":[53],"used":[54],"in":[55,91,197,206,227],"OHT":[56],"patients":[57,134,161,228],"may":[58,67],"differentially":[59],"affect":[60],"In":[63],"particular,":[64],"mTOR":[65,87,136,164,208,230],"inhibitors":[66,137,165,177],"modulate":[68],"viral":[69],"replication":[70],"immune":[72],"responses,":[73],"potentially":[74],"influencing":[75],"disease":[76],"severity.":[77],"OBJECTIVES:":[78],"This":[79,108],"study":[80,112,158],"evaluated":[81],"impact":[83],"regimens-particularly":[86],"inhibitors-on":[88],"outcomes":[90],"recipients,":[94,141],"comparing":[95],"mTOR-based":[96,212],"(with":[98],"or":[99,167],"without":[100],"calcineurin":[101,176],"inhibitors,":[102],"CNIs)":[103],"non-mTOR-based":[105],"regimens.":[106],"METHODS:":[107],"single-center":[109],"retrospective":[110],"observational":[111],"included":[113],"556":[114],"(76.3%":[119],"male;":[120],"median":[121],"age,":[122,150],"58":[123],"years)":[124],"followed":[125],"from":[126,184],"March":[127,130],"2020":[128],"2024.":[131],"To":[132],"compare":[133],"receiving":[135],"similar":[139],"non-mTOR":[140],"3:1":[142],"propensity":[143],"score":[144],"matching":[145],"was":[146,214],"performed":[147],"based":[148],"on":[149,229],"sex,":[151],"body":[153],"mass":[154],"index.":[155],"Among":[156],"population,":[159],"88":[160],"(15.8%)":[162],"received":[163],"(everolimus":[166],"sirolimus),":[168],"whom":[170],"66":[171],"were":[172,182],"concomitantly":[173],"treated":[174],"22":[179],"without.":[180],"Data":[181],"obtained":[183],"National":[186],"Health":[187],"Fund":[188],"database":[189],"clinical":[191],"follow-ups.":[192],"RESULTS:":[193],"=":[194],"0.02),":[195],"especially":[196],"mTOR+CNI":[199],"subgroup.":[200],"Notably,":[201],"no":[202],"COVID-19-related":[203,225],"deaths":[204,226],"occurred":[205],"CNI-free":[209,231],"group.":[210],"CONCLUSIONS:":[211],"non-inferior":[215],"standard":[217],"outcomes.":[221],"absence":[223],"regimens":[232],"suggests":[233],"potential":[234],"protective":[235],"effects":[236],"that":[237],"merit":[238],"further":[239],"investigation.":[240]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-12-24T00:00:00"}