{"id":"https://openalex.org/W7116842265","doi":"https://doi.org/10.11124/jbies-24-00420","title":"Signs and symptoms of acute tacrolimus toxicity in solid organ transplant recipients: a scoping review protocol","display_name":"Signs and symptoms of acute tacrolimus toxicity in solid organ transplant recipients: a scoping review protocol","publication_year":2025,"publication_date":"2025-12-23","ids":{"openalex":"https://openalex.org/W7116842265","doi":"https://doi.org/10.11124/jbies-24-00420","pmid":"https://pubmed.ncbi.nlm.nih.gov/41431833"},"language":"en","primary_location":{"id":"doi:10.11124/jbies-24-00420","doi":"https://doi.org/10.11124/jbies-24-00420","is_oa":false,"landing_page_url":"https://doi.org/10.11124/jbies-24-00420","pdf_url":null,"source":{"id":"https://openalex.org/S4210227357","display_name":"JBI Evidence Synthesis","issn_l":"2689-8381","issn":["2689-8381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JBI Evidence Synthesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042587223","display_name":"L\u00eddia Einsfeld","orcid":"https://orcid.org/0000-0002-5222-233X","observed_orcids":["https://orcid.org/0000-0002-5222-233X"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"L\u00eddia Einsfeld","raw_affiliation_strings":["Clinical Pharmacy Section, Hospital de Cl\u00ednicas de Porto Alegre, Brazil","Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Rio Grande do Sul, Porto Alegre, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5222-233X","affiliations":[{"raw_affiliation_string":"Clinical Pharmacy Section, Hospital de Cl\u00ednicas de Porto Alegre, Brazil","institution_ids":["https://openalex.org/I4210097146"]},{"raw_affiliation_string":"Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Rio Grande do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079785895","display_name":"Kathleen Asturian","orcid":"https://orcid.org/0000-0003-3433-0385","observed_orcids":["https://orcid.org/0000-0003-3433-0385"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Kathleen Asturian","raw_affiliation_strings":["Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Rio Grande do Sul, Porto Alegre, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-3433-0385","affiliations":[{"raw_affiliation_string":"Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Rio Grande do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008212233","display_name":"Diogo Pilger","orcid":"https://orcid.org/0000-0002-8171-2688","observed_orcids":["https://orcid.org/0000-0002-8171-2688"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Diogo Pilger","raw_affiliation_strings":["Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Rio Grande do Sul, Porto Alegre, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-8171-2688","affiliations":[{"raw_affiliation_string":"Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Rio Grande do Sul, Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042587223"],"corresponding_institution_ids":["https://openalex.org/I130442723","https://openalex.org/I4210097146"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65977123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"3","first_page":"598","last_page":"606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.7968999743461609,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.07930000126361847,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11635","display_name":"Poisoning and overdose treatments","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.8650000095367432},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.6449999809265137},{"id":"https://openalex.org/keywords/solid-organ-transplantation","display_name":"solid organ transplantation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clinical-signs-and-symptoms","display_name":"clinical signs and symptoms","score":0.9330000281333923},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.6140000224113464},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8884999752044678},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.4828000068664551},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42879998683929443},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.38499999046325684},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3555000126361847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32850000262260437},{"id":"https://openalex.org/C3018875020","wikidata":"https://www.wikidata.org/wiki/Q1441305","display_name":"Signs and symptoms","level":2,"score":0.31949999928474426},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C168444539","wikidata":"https://www.wikidata.org/wiki/Q105196","display_name":"Organ transplantation","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2621999979019165}],"mesh":[{"descriptor_ui":"D000098584","descriptor_name":"Scoping Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098584","descriptor_name":"Scoping Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098584","descriptor_name":"Scoping Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016377","descriptor_name":"Organ Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016377","descriptor_name":"Organ Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016377","descriptor_name":"Organ Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016559","descriptor_name":"Tacrolimus","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066027","descriptor_name":"Transplant Recipients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.11124/jbies-24-00420","doi":"https://doi.org/10.11124/jbies-24-00420","is_oa":false,"landing_page_url":"https://doi.org/10.11124/jbies-24-00420","pdf_url":null,"source":{"id":"https://openalex.org/S4210227357","display_name":"JBI Evidence Synthesis","issn_l":"2689-8381","issn":["2689-8381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JBI Evidence Synthesis","raw_type":"journal-article"},{"id":"pmid:41431833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41431833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JBI evidence synthesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1970749259","https://openalex.org/W1998460493","https://openalex.org/W2012728731","https://openalex.org/W2059676586","https://openalex.org/W2080875294","https://openalex.org/W2119661979","https://openalex.org/W2782679344","https://openalex.org/W2891378911","https://openalex.org/W2892590175","https://openalex.org/W3040993146","https://openalex.org/W3134180906","https://openalex.org/W4211117577","https://openalex.org/W4293513742","https://openalex.org/W4321487676","https://openalex.org/W4366769304","https://openalex.org/W4372183527","https://openalex.org/W4386501693","https://openalex.org/W4389670233","https://openalex.org/W4391341100"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"The":[1,170],"objective":[2],"of":[3,21,94,123,179,196],"the":[4,28,113,142,149,156,193,251],"review":[5,139],"is":[6,27],"to":[7,45,155],"chart":[8],"clinical":[9,55],"signs":[10],"and":[11,62,75,97,148,163,192,223,250,256],"symptoms":[12,224],"presented":[13,225,253],"by":[14,219,226,260],"solid":[15,82],"organ":[16,36,83],"recipients":[17,84],"when":[18],"serum":[19,50,92,129],"levels":[20,51,93,130],"tacrolimus":[22,91,128],"are":[23,72,98,131],"supratherapeutic.":[24],"INTRODUCTION:":[25],"Tacrolimus":[26],"worldwide":[29],"standard":[30],"immunosuppressive":[31],"agent":[32],"used":[33],"in":[34,254],"post-solid":[35],"transplantation.":[37],"However,":[38],"this":[39],"narrow-index":[40],"therapeutic":[41],"drug":[42],"can":[43],"lead":[44],"acute":[46,229],"toxicity":[47,230],"at":[48],"supratherapeutic":[49],"(\u226520":[52],"ng/mL).":[53],"This":[54,138],"scenario":[56],"evolves":[57],"dynamically,":[58],"making":[59],"its":[60,70],"diagnosis":[61],"urgent":[63],"treatment":[64],"difficult":[65],"for":[66,105,145,160,166],"transplant":[67],"teams,":[68],"while":[69],"sequelae":[71],"potentially":[73],"serious":[74],"even":[76],"fatal.":[77],"ELIGIBILITY":[78],"CRITERIA:":[79],"Studies":[80,119],"on":[81,112,120],"(heart,":[85],"lung,":[86],"kidney,":[87],"liver)":[88],"who":[89],"had":[90],"\u226520":[95],"ng/mL":[96],"aged":[99],"\u226518":[100],"years":[101],"will":[102,108,134,140,151,173,202,211,215,231,244],"be":[103,109,135,152,174,204,212,216,232,245],"considered":[104],"inclusion.":[106],"There":[107],"no":[110],"limits":[111,210],"care":[114],"setting":[115],"or":[116,125,208],"geographic":[117],"location.":[118],"other":[121],"types":[122],"transplants":[124],"studies":[126,235],"where":[127],"not":[132],"reported":[133,153],"excluded.":[136],"METHODS:":[137],"follow":[141],"JBI":[143,239],"methodology":[144],"scoping":[146],"reviews,":[147],"results":[150,252],"according":[154],"Preferred":[157],"Reporting":[158],"Items":[159],"Systematic":[161,197],"Reviews":[162,168],"Meta-Analyses":[164],"extension":[165],"Scoping":[167],"(PRISMA-ScR).":[169],"following":[171],"databases":[172],"searched:":[175],"MEDLINE":[176],"(Ovid),":[177,186],"Web":[178],"Science,":[180],"Scielo":[181],"(BIREME),":[182],"LILACS":[183],"(BVS),":[184],"Embase":[185],"CINAHL":[187],"(EBSCOhost),":[188],"Scopus,":[189],"Cochrane":[190,194],"CENTRAL,":[191],"Database":[195],"Reviews.":[198],"Gray":[199],"literature":[200],"sources":[201],"also":[203],"searched.":[205],"No":[206],"date":[207],"language":[209],"applied.":[213],"Reports":[214],"independently":[217],"screened":[218],"2":[220],"researchers.":[221],"Signs":[222],"patients":[227],"during":[228],"extracted":[233],"from":[234],"using":[236,247],"a":[237],"modified":[238],"data":[240],"extraction":[241],"tool.":[242],"Data":[243],"analyzed":[246],"descriptive":[248],"statistics":[249],"tabular":[255],"graphical":[257],"formats,":[258],"accompanied":[259],"narrative":[261],"summaries.":[262],"REVIEW":[263],"REGISTRATION:":[264],"OSF":[265],"osf.io/f7tzu/.":[266]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-12-23T00:00:00"}
