{"id":"https://openalex.org/W7113687319","doi":null,"title":"Machine learning discoveries of 2nd order combinations in peripheral blood mononuclear cells (PBMCs) strongly activated in fatal West African Ebola Virus (EBOV) Disease (EVD)","display_name":"Machine learning discoveries of 2nd order combinations in peripheral blood mononuclear cells (PBMCs) strongly activated in fatal West African Ebola Virus (EBOV) Disease (EVD)","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7113687319"},"language":"en","primary_location":{"id":"pmh:oai:share.osf.io:a01feec8-10ea-480d-a34a-b24a6c562a06","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/v6wr5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://osf.io/v6wr5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045112901","display_name":"Shriprakash Sinha","orcid":"https://orcid.org/0000-0001-7027-5788","observed_orcids":["https://orcid.org/0000-0001-7027-5788"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"shriprakash sinha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045112901"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebola-virus-disease","display_name":"Ebola virus disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.8230000138282776},{"id":"https://openalex.org/keywords/gene-combinations","display_name":"gene combinations","score":0.6660000085830688},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8230000138282776},{"id":"https://openalex.org/keywords/pancreatic-enzymes","display_name":"pancreatic enzymes","score":0.6790000200271606},{"id":"https://openalex.org/keywords/host-response","display_name":"host response","score":0.6079999804496765},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.46000000834465027},{"id":"https://openalex.org/keywords/differential-gene-expression","display_name":"differential gene expression","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.8148000240325928},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7159000039100647},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5830000042915344},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5734999775886536},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5022000074386597},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49729999899864197},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4864000082015991},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44440001249313354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C2909623084","wikidata":"https://www.wikidata.org/wiki/Q5331908","display_name":"Ebolavirus","level":4,"score":0.4049000144004822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3625999987125397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32670000195503235},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3133000135421753},{"id":"https://openalex.org/C2910344980","wikidata":"https://www.wikidata.org/wiki/Q51993","display_name":"Ebola Hemorrhagic Fever","level":4,"score":0.30720001459121704},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.26409998536109924},{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.2583000063896179},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2556999921798706}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:share.osf.io:a01feec8-10ea-480d-a34a-b24a6c562a06","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/v6wr5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"}],"best_oa_location":{"id":"pmh:oai:share.osf.io:a01feec8-10ea-480d-a34a-b24a6c562a06","doi":null,"is_oa":true,"landing_page_url":"https://osf.io/v6wr5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7107950439","https://openalex.org/W7117137192","https://openalex.org/W7147267421","https://openalex.org/W2768924721","https://openalex.org/W7154567363","https://openalex.org/W4401090115","https://openalex.org/W2758557957","https://openalex.org/W7095233743","https://openalex.org/W2579523860","https://openalex.org/W3139283208"],"abstract_inverted_index":{"The":[0],"pathogenesis":[1],"of":[2,30,51,76,81,117,156,174,189,211,249,260,282,319,328,342,359],"human":[3,199,273],"Ebola":[4,68],"virus":[5,69],"disease":[6],"(EVD)":[7],"is":[8,204,253],"complex":[9],"and":[10,36,65,127,158,324,332],"to":[11,17,59,106,134,152,170,226,254,272,369],"clarify":[12],"how":[13],"host":[14],"responses":[15],"contribute":[16],"EVD":[18,39,45,296],"pathophysiology,":[19],"Amie":[20],"J":[21],"Eisfeld":[22],"et.":[23],"al.":[24],"2017":[25],"performed":[26],"multi-platform":[27],"'omics":[28],"analysis":[29],"peripheral":[31],"blood":[32],"mononuclear":[33],"cells":[34],"(PMBCs)":[35],"plasma":[37],"from":[38],"patients.":[40],"Their":[41],"results":[42],"pointed":[43],"that":[44,55,67,96,142,160,193,203,216],"molecular":[46],"signatures":[47],"overlapped":[48],"with":[49,145,163,270],"those":[50],"sepsis,":[52],"thus":[53],"indicating":[54],"pancreatic":[56],"enzymes":[57],"contributed":[58],"tissue":[60],"damage":[61],"in":[62,93,198,232,245,262,295,308,321,345],"fatal":[63,82],"EVD,":[64,237],"suggested":[66],"infection":[70],"might":[71,194,217,230,304,354],"induce":[72],"aberrant":[73],"neutrophils":[74],"(activities":[75],"which":[77,150,168,185,301],"could":[78],"explain":[79],"hallmarks":[80],"EVD).":[83],"For":[84],"this,":[85],"they":[86],"record":[87],"Table":[88],"S5":[89],"i.e":[90],"file":[91],"NIHMS922130-supplement-5.xlsx,":[92],"their":[94],"supplementary,":[95],"contains":[97,114],"the":[98,108,236,247,256,263,317,326],"comparison":[99],"for":[100,121,187,235,292,357],"Fatalities":[101],"vs.":[102],"healthy":[103],"controls":[104],"(FvsH),":[105],"study":[107,255],"PMBC":[109,267],"transcriptome":[110,268],"data.":[111],"This":[112],"table":[113],"a":[115,146,153,164,171,209,285],"list":[116],"11804":[118],"unique":[119],"genes,":[120,176],"whom":[122],"log2":[123],"fold":[124],"change":[125],"(logFC)":[126],"q-value":[128],"(adj.P.Val),":[129],"have":[130],"been":[131],"recorded.":[132],"Due":[133],"limited":[135,347],"computational":[136],"power":[137],"/":[138],"resources,":[139],"only":[140],"genes":[141,159,190,261,293],"are":[143,161,177,180],"(up)-regulated":[144],"logFC":[147,165],">=":[148],"0.3,":[149],"accounts":[151,169],"total":[154,172],"number":[155,173],"3327,":[157],"(down)-regulated":[162],"<":[166],"-0.3,":[167],"3529":[175],"considered.":[178],"There":[179],"not":[181],"much":[182],"genomic":[183],"studies":[184],"account":[186],"combinations":[188,281,303,341,353],"or":[191],"factors":[192,215],"be":[195,218,305],"working":[196,219,306],"synergistically":[197,220,307],"EVD.":[200,274,309,370],"Because,":[201],"if":[202,349],"done,":[205],"it":[206],"would":[207],"open":[208],"range":[210],"insights":[212],"into":[213],"multiple":[214],"at":[221,288,364],"say,":[222],"2nd":[223,257,289],"order":[224,258,290],"level,":[225],"start":[227],"with.":[228],"These":[229,298],"help":[231],"developing":[233],"therapeutics":[234],"based":[238,361],"on":[239],"synergistic":[240],"mechanisms.":[241],"With":[242],"this":[243,250,335],"aim":[244],"mind,":[246],"idea":[248],"current":[251],"manuscript":[252],"rankings":[259,299],"FvsH":[264],"case,":[265],"using":[266],"data":[269],"respect":[271],"A":[275],"recently":[276],"developed":[277],"search":[278],"engine":[279],"ranked":[280],"Y-X":[283,302],"(X,":[284],"particular":[286],"gene/protein)":[287],"level":[291],"involved":[294],"cases.":[297],"reveal":[300],"If":[310],"found":[311],"true,":[312,351],"virologists":[313],"can":[314],"further":[315],"test":[316],"combination":[318],"interest":[320],"wet":[322],"lab":[323],"determine":[325],"mechanism":[327],"functioning":[329],"between":[330],"Y":[331],"X.":[333],"In":[334],"research":[336],"work,":[337],"we":[338],"cover":[339],"various":[340],"Y-X.":[343],"Further,":[344],"my":[346],"grasp,":[348],"proven":[350],"these":[352],"pave":[355],"way":[356],"development":[358],"gene":[360],"therapies":[362],"aimed":[363],"resolving":[365],"pathological":[366],"issues":[367],"related":[368]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-12-10T00:00:00"}
