{"id":"https://openalex.org/W7112422161","doi":null,"title":"Post-Translational Modification Of The Low-Density Lipoprotein Receptor By Serine Proteases","display_name":"Post-Translational Modification Of The Low-Density Lipoprotein Receptor By Serine Proteases","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W7112422161"},"language":"en","primary_location":{"id":"pmh:oai:stars.library.ucf.edu:hut2024-1237","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/hut2024/329","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Undergraduate Theses","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://stars.library.ucf.edu/hut2024/329","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ruiz, Matthew E","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ruiz, Matthew E","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32516021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.9710000157356262},{"id":"https://openalex.org/keywords/prostasin","display_name":"prostasin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.9419999718666077},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hepsin","display_name":"hepsin","score":0.703000009059906},{"id":"https://openalex.org/keywords/matriptase","display_name":"matriptase","score":1.0},{"id":"https://openalex.org/keywords/sterol-regulatory-element-binding-proteins","display_name":"SREBP","score":0.6690000295639038},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9200000166893005},{"id":"https://openalex.org/keywords/ldl-uptake","display_name":"LDL uptake","score":0.7789999842643738},{"id":"https://openalex.org/keywords/receptor-cleavage","display_name":"receptor cleavage","score":0.7839999794960022},{"id":"https://openalex.org/keywords/extracellular-domain","display_name":"extracellular domain","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cholesterol-homeostasis","display_name":"cholesterol homeostasis","score":0.6290000081062317},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.7504000067710876},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.6748999953269958},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6266999840736389},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5629000067710876},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5253999829292297},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5210999846458435},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.49810001254081726},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.48750001192092896},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4796000123023987},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46650001406669617},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.4512999951839447},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4456999897956848},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4025000035762787},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.39590001106262207},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.382099986076355},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.37959998846054077},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3255999982357025},{"id":"https://openalex.org/C2779620165","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Low-density lipoprotein","level":3,"score":0.30079999566078186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2915000021457672},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.28999999165534973},{"id":"https://openalex.org/C2777704780","wikidata":"https://www.wikidata.org/wiki/Q21115210","display_name":"ABCA1","level":4,"score":0.28870001435279846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28439998626708984},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.2660999894142151},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.25200000405311584},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:stars.library.ucf.edu:hut2024-1237","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/hut2024/329","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Undergraduate Theses","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:stars.library.ucf.edu:hut2024-1237","doi":null,"is_oa":true,"landing_page_url":"https://stars.library.ucf.edu/hut2024/329","pdf_url":null,"source":{"id":"https://openalex.org/S4210172555","display_name":"Journal of International Crisis and Risk Communication Research","issn_l":"2576-0017","issn":["2576-0017","2576-0025"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Honors Undergraduate Theses","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7161922231","https://openalex.org/W4391653796","https://openalex.org/W2743653840","https://openalex.org/W4405047128","https://openalex.org/W2146769790","https://openalex.org/W2079578984","https://openalex.org/W7161828494","https://openalex.org/W2327570147","https://openalex.org/W2136034547","https://openalex.org/W2054681857"],"abstract_inverted_index":{"Hypercholesterolemia":[0],"is":[1,244],"a":[2,25,110,150],"disease":[3,33],"affecting":[4],"many":[5],"Americans":[6],"and":[7,10,64,80,108,118,126,159,174,228,230],"adults":[8],"worldwide":[9],"can":[11,53,223,237],"lead":[12],"to":[13,101,137,197,214,246,288,292],"further":[14],"complications":[15],"such":[16],"as":[17,62,277],"atherosclerosis,":[18],"stroke,":[19],"or":[20,82,89,177,208],"pulmonary":[21],"embolisms":[22],"making":[23],"it":[24],"major":[26],"risk":[27],"factor":[28],"for":[29,59],"heart":[30],"disease.":[31],"The":[32,97],"states":[34],"are":[35,99,279],"caused":[36],"by":[37,226,240,251,282],"chronically":[38],"elevated":[39],"levels":[40,133],"of":[41,105,149,156,188,233,296],"VLDLs":[42],"that":[43,221],"get":[44],"broken":[45],"down":[46],"into":[47,129],"LDLs.":[48],"Cells":[49],"expressing":[50],"the":[51,57,70,94,103,106,116,122,139,147,154,157,169,175,179,185,189,198,234,248,258,262,273,283,290,294,297],"LDLR":[52,107,158,190,259,274,298],"endocytose":[54],"LDLs":[55],"from":[56,93],"blood":[58],"use":[60],"intracellularly":[61],"cholesterol":[63,67,87,91,131],"prevent":[65],"plasma":[66,132],"deposition":[68],"in":[69,161,168,178,202,272],"endothelium.":[71],"Current":[72],"treatments":[73,84],"include":[74],"leading":[75],"healthier":[76],"lifestyles":[77],"through":[78,134],"dieting":[79],"exercise,":[81],"pharmacological":[83,135],"targeting":[85],"cellular":[86],"production":[88],"dietary":[90],"uptake":[92,124],"GI":[95],"tract.":[96],"SREBPs":[98],"known":[100],"upregulate":[102],"expression":[104,275],"prostasin,":[109],"serine":[111,255],"protease.":[112],"A":[113],"connection":[114],"between":[115,153],"receptor":[117],"protease":[119],"would":[120],"elucidate":[121],"LDL":[123],"pathway":[125,276],"prompt":[127],"investigations":[128],"regulating":[130],"inhibition":[136],"elevate":[138],"LDLR\u2019s":[140],"expression.":[141],"However,":[142],"this":[143],"study\u2019s":[144],"results":[145],"indicate":[146],"absence":[148],"direct":[151],"relationship":[152],"cleavage":[155,232],"prostasin":[160,173,227,286],"vitro.":[162],"Cleavage":[163,187],"products":[164],"were":[165],"not":[166],"observed":[167,201],"HEK293":[170,203],"co-transfected":[171,205],"with":[172,184,206],"LDLR,":[176],"prostasin-expressing":[180],"HeLa":[181],"cells":[182,204],"transfected":[183],"LDLR.":[186],"extracellular":[191],"domain":[192],"(ECD)":[193],"at":[194,261],"sites":[195],"close":[196],"membrane":[199,254],"was":[200],"hepsin":[207],"matriptase,":[209],"two":[210],"closely":[211],"related":[212],"proteases":[213,256],"prostasin.":[215,241],"It":[216],"had":[217],"been":[218],"shown":[219],"previously":[220],"matriptase":[222,231],"be":[224,238],"activated":[225],"hepsin,":[229],"EGFR":[235],"ECD":[236,295],"enhanced":[239],"Further":[242],"study":[243],"necessary":[245],"determine":[247],"precise":[249],"mechanisms":[250],"which":[252],"these":[253],"regulate":[257],"presentation":[260],"cell":[263],"surface.":[264],"Prostasin":[265],"may":[266],"still":[267],"have":[268],"an":[269],"unknown":[270],"role":[271],"they":[278],"both":[280],"regulated":[281],"SREBPs,":[284],"however,":[285],"appears":[287],"lack":[289],"ability":[291],"cleave":[293],"directly.":[299]},"counts_by_year":[],"updated_date":"2026-03-04T07:09:34.246503","created_date":"2025-12-10T00:00:00"}