{"id":"https://openalex.org/W7112386644","doi":null,"title":"Predicting and understanding treatment response in infectious and oncological diseases using transcriptomic data and computational approaches","display_name":"Predicting and understanding treatment response in infectious and oncological diseases using transcriptomic data and computational approaches","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W7112386644"},"language":"en","primary_location":{"id":"pmh:oai:www.tdx.cat:10803/695972","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/695972","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10803/695972","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031323496","display_name":"Juan Manuel Garc\u00eda\u2010Illarramendi","orcid":"https://orcid.org/0000-0003-3368-814X","observed_orcids":["https://orcid.org/0000-0003-3368-814X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Garc\u00eda Illarramendi, Juan Manuel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031323496"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.1746000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.7760000228881836},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.847000002861023},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/treatment-response-prediction","display_name":"treatment response prediction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/transcriptomic-biomarkers","display_name":"transcriptomic biomarkers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":0.7670000195503235},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5460000038146973},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6759999990463257},{"id":"https://openalex.org/keywords/monocyte-to-lymphocyte-ratio","display_name":"monocyte-to-lymphocyte ratio","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.4320000112056732},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.49300000071525574},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.3580000102519989},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.3449999988079071},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5690000057220459},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.49799999594688416},{"id":"https://openalex.org/keywords/host-tissue-damage","display_name":"host tissue damage","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.5989000201225281},{"id":"https://openalex.org/C58640448","wikidata":"https://www.wikidata.org/wiki/Q42515","display_name":"Cartography","level":1,"score":0.4300999939441681},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3003000020980835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2768999934196472},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.24009999632835388},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.1890999972820282},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14390000700950623},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13910000026226044},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.13729999959468842},{"id":"https://openalex.org/C3018573395","wikidata":"https://www.wikidata.org/wiki/Q606591","display_name":"Pet therapy","level":3,"score":0.13699999451637268}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.tdx.cat:10803/695972","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/695972","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:ddd.uab.cat:322823","doi":null,"is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/322823","pdf_url":"https://ddd.uab.cat/pub/tesis/2025/hdl_10803_695972/jmgi1de1.pdf","source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Tesi doctoral"}],"best_oa_location":{"id":"pmh:oai:www.tdx.cat:10803/695972","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/695972","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7112386644.pdf","grobid_xml":"https://content.openalex.org/works/W7112386644.grobid-xml"},"referenced_works_count":281,"referenced_works":["https://openalex.org/W1535350845","https://openalex.org/W1539219439","https://openalex.org/W1542823905","https://openalex.org/W1544009106","https://openalex.org/W1566906897","https://openalex.org/W1840268501","https://openalex.org/W1922733886","https://openalex.org/W1934094702","https://openalex.org/W1969825132","https://openalex.org/W1971224531","https://openalex.org/W1971463294","https://openalex.org/W1973108221","https://openalex.org/W1976443390","https://openalex.org/W1981509058","https://openalex.org/W1985987855","https://openalex.org/W1989921625","https://openalex.org/W1989938935","https://openalex.org/W1994568187","https://openalex.org/W2005494948","https://openalex.org/W2006562605","https://openalex.org/W2006824814","https://openalex.org/W2007186942","https://openalex.org/W2010417263","https://openalex.org/W2016791396","https://openalex.org/W2017047594","https://openalex.org/W2020541351","https://openalex.org/W2021062665","https://openalex.org/W2034710584","https://openalex.org/W2037679360","https://openalex.org/W2062878272","https://openalex.org/W2063125629","https://openalex.org/W2063382533","https://openalex.org/W2071962206","https://openalex.org/W2076295728","https://openalex.org/W2080997194","https://openalex.org/W2086034911","https://openalex.org/W2089759450","https://openalex.org/W2091774189","https://openalex.org/W2092710950","https://openalex.org/W2095201384","https://openalex.org/W2096122707","https://openalex.org/W2097121246","https://openalex.org/W2101988363","https://openalex.org/W2102152191","https://openalex.org/W2104162471","https://openalex.org/W2105683151","https://openalex.org/W2105882193","https://openalex.org/W2106965705","https://openalex.org/W2106983577","https://openalex.org/W2108516575","https://openalex.org/W2109972881","https://openalex.org/W2111823238","https://openalex.org/W2111851685","https://openalex.org/W2111947696","https://openalex.org/W2115735904","https://openalex.org/W2115790682","https://openalex.org/W2116041602","https://openalex.org/W2118258530","https://openalex.org/W2118632896","https://openalex.org/W2119746400","https://openalex.org/W2120291439","https://openalex.org/W2120456037","https://openalex.org/W2121211805","https://openalex.org/W2121847974","https://openalex.org/W2122915854","https://openalex.org/W2123125245","https://openalex.org/W2125447919","https://openalex.org/W2125885282","https://openalex.org/W2125942839","https://openalex.org/W2128212390","https://openalex.org/W2128215249","https://openalex.org/W2131271579","https://openalex.org/W2132754339","https://openalex.org/W2133590486","https://openalex.org/W2134118500","https://openalex.org/W2134539328","https://openalex.org/W2137417501","https://openalex.org/W2140043667","https://openalex.org/W2142564546","https://openalex.org/W2145559868","https://openalex.org/W2146512944","https://openalex.org/W2147834058","https://openalex.org/W2148202982","https://openalex.org/W2149119575","https://openalex.org/W2149785901","https://openalex.org/W2151595861","https://openalex.org/W2154391127","https://openalex.org/W2154941270","https://openalex.org/W2156480428","https://openalex.org/W2159179344","https://openalex.org/W2159444728","https://openalex.org/W2161036119","https://openalex.org/W2161893150","https://openalex.org/W2163562805","https://openalex.org/W2164035913","https://openalex.org/W2167155713","https://openalex.org/W2168579528","https://openalex.org/W2169456326","https://openalex.org/W2287133162","https://openalex.org/W2309097152","https://openalex.org/W2310773425","https://openalex.org/W2314927739","https://openalex.org/W2337758174","https://openalex.org/W2340187745","https://openalex.org/W2341263524","https://openalex.org/W2397800570","https://openalex.org/W2403934794","https://openalex.org/W2426599974","https://openalex.org/W2430731787","https://openalex.org/W2435243879","https://openalex.org/W2464310892","https://openalex.org/W2471536144","https://openalex.org/W2484544705","https://openalex.org/W2515844826","https://openalex.org/W2529170873","https://openalex.org/W2530590137","https://openalex.org/W2531859512","https://openalex.org/W2549966893","https://openalex.org/W2559024717","https://openalex.org/W2589193607","https://openalex.org/W2591303105","https://openalex.org/W2592811885","https://openalex.org/W2671324896","https://openalex.org/W2726218630","https://openalex.org/W2739132742","https://openalex.org/W2767921562","https://openalex.org/W2778413884","https://openalex.org/W2788443790","https://openalex.org/W2789128799","https://openalex.org/W2791410762","https://openalex.org/W2792558334","https://openalex.org/W2793662479","https://openalex.org/W2794576820","https://openalex.org/W2796691218","https://openalex.org/W2797791374","https://openalex.org/W2810647922","https://openalex.org/W2889746019","https://openalex.org/W2902530914","https://openalex.org/W2912364350","https://openalex.org/W2921768356","https://openalex.org/W2923956523","https://openalex.org/W2941650309","https://openalex.org/W2942068613","https://openalex.org/W2943196840","https://openalex.org/W2944446380","https://openalex.org/W2946370795","https://openalex.org/W2947023371","https://openalex.org/W2947368789","https://openalex.org/W2948127603","https://openalex.org/W2948373913","https://openalex.org/W2950073687","https://openalex.org/W2953263404","https://openalex.org/W2953287793","https://openalex.org/W2955570986","https://openalex.org/W2962300879","https://openalex.org/W2966039277","https://openalex.org/W2967576920","https://openalex.org/W2968351906","https://openalex.org/W2971226421","https://openalex.org/W2978549968","https://openalex.org/W2990360409","https://openalex.org/W2991467849","https://openalex.org/W2993347499","https://openalex.org/W3006930853","https://openalex.org/W3007686018","https://openalex.org/W3022091067","https://openalex.org/W3027448020","https://openalex.org/W3036088872","https://openalex.org/W3036345778","https://openalex.org/W3042347895","https://openalex.org/W3047204892","https://openalex.org/W3080310430","https://openalex.org/W3080668573","https://openalex.org/W3110500961","https://openalex.org/W3113072416","https://openalex.org/W3119858057","https://openalex.org/W3121985000","https://openalex.org/W3123642801","https://openalex.org/W3125581240","https://openalex.org/W3127937621","https://openalex.org/W3129557755","https://openalex.org/W3130781357","https://openalex.org/W3133831426","https://openalex.org/W3135755572","https://openalex.org/W3136653115","https://openalex.org/W3150744798","https://openalex.org/W3158806613","https://openalex.org/W3172174831","https://openalex.org/W3173705400","https://openalex.org/W3175173749","https://openalex.org/W3179876992","https://openalex.org/W3180586010","https://openalex.org/W3181778966","https://openalex.org/W3182947028","https://openalex.org/W3184322803","https://openalex.org/W3191661929","https://openalex.org/W3194301212","https://openalex.org/W3194945739","https://openalex.org/W3195215840","https://openalex.org/W3198702060","https://openalex.org/W3202723367","https://openalex.org/W3202940825","https://openalex.org/W3206354888","https://openalex.org/W3208500803","https://openalex.org/W3208729038","https://openalex.org/W3210558381","https://openalex.org/W3212342036","https://openalex.org/W3212362104","https://openalex.org/W3214280461","https://openalex.org/W3215119546","https://openalex.org/W3215682729","https://openalex.org/W4200043367","https://openalex.org/W4205391505","https://openalex.org/W4205648935","https://openalex.org/W4206012291","https://openalex.org/W4206693544","https://openalex.org/W4212802567","https://openalex.org/W4213177438","https://openalex.org/W4220676272","https://openalex.org/W4221016610","https://openalex.org/W4221123198","https://openalex.org/W4234401042","https://openalex.org/W4247420482","https://openalex.org/W4250492534","https://openalex.org/W4281559326","https://openalex.org/W4282045748","https://openalex.org/W4284886740","https://openalex.org/W4284963678","https://openalex.org/W4285586347","https://openalex.org/W4285992810","https://openalex.org/W4286433154","https://openalex.org/W4293769755","https://openalex.org/W4295096627","https://openalex.org/W4295941747","https://openalex.org/W4309184100","https://openalex.org/W4309230208","https://openalex.org/W4309937258","https://openalex.org/W4311939666","https://openalex.org/W4319063675","https://openalex.org/W4322719806","https://openalex.org/W4323534104","https://openalex.org/W4362455425","https://openalex.org/W4367835002","https://openalex.org/W4382196729","https://openalex.org/W4385664314","https://openalex.org/W4386390703","https://openalex.org/W4386930643","https://openalex.org/W4387859726","https://openalex.org/W4388539829","https://openalex.org/W4388615774","https://openalex.org/W4389626033","https://openalex.org/W4389924926","https://openalex.org/W4390739423","https://openalex.org/W4391603963","https://openalex.org/W4391777496","https://openalex.org/W4391931207","https://openalex.org/W4391954002","https://openalex.org/W4392783666","https://openalex.org/W4393043605","https://openalex.org/W4393074242","https://openalex.org/W4393098331","https://openalex.org/W4400040408","https://openalex.org/W4400070286","https://openalex.org/W4400735087","https://openalex.org/W4401516141","https://openalex.org/W4401644815","https://openalex.org/W4403285022","https://openalex.org/W4403745076","https://openalex.org/W4403824387","https://openalex.org/W4403869979","https://openalex.org/W4404159925","https://openalex.org/W4404703157","https://openalex.org/W4404725547","https://openalex.org/W4406155365","https://openalex.org/W4406820204","https://openalex.org/W4408372348","https://openalex.org/W4410215740","https://openalex.org/W4410805175","https://openalex.org/W4410822778","https://openalex.org/W4414190539","https://openalex.org/W7166835223"],"related_works":["https://openalex.org/W6987428485","https://openalex.org/W4307171237","https://openalex.org/W4280508234","https://openalex.org/W6982245801","https://openalex.org/W2951427165","https://openalex.org/W7120426056","https://openalex.org/W4414973575","https://openalex.org/W2324008566","https://openalex.org/W6987696800","https://openalex.org/W629625901"],"abstract_inverted_index":{"Aquesta":[0],"tesi":[1,75],"investiga":[2],"l'aplicaci\u00f3":[3],"de":[4,31,62,66,122,155,184,186,224,234,259,278,280,293,303,317,343,346,366,390,419,495,498,508,510],"dades":[5,209,360,444],"transcript\u00f2miques":[6,157,342,361,445],"per":[7,272,307,362,468,481,492],"avaluar,":[8],"modelar":[9],"i":[10,36,68,151,165,180,213,230,257,311,368,409,417,430,459,471,500],"predir":[11],"la":[12,22,56,60,64,96,143,160,200,222,225,274,291,315,344,454,461,469],"resposta":[13,57,97,161,201,275,455],"als":[14,26,456],"tractaments":[15],"en":[16,21,78,95,102,120,130,133,142,146,152,172,221,254,284,332,352,382,426,453],"diversos":[17],"contextos":[18],"patol\u00f2gics,":[19],"concretament":[20],"tuberculosi":[23],"pulmonar":[24,256],"resistent":[25],"f\u00e0rmacs":[27],"(TB),":[28],"el":[29,37,47,69,100,117,134,181,231,472],"c\u00e0ncer":[30,38],"mama":[32],"triple":[33],"negatiu":[34],"(TNBC)":[35],"colorectal":[39],"metast\u00e0tic":[40],"(mCRC).":[41],"La":[42,74],"hip\u00f2tesi":[43],"central":[44],"\u00e9s":[45,466],"que":[46,82,111,166,336,442,451,460,477],"perfil":[48,183],"transcript\u00f2mic":[49],"pot":[50],"revelar":[51,447],"mecanismes":[52],"biol\u00f2gics":[53],"subjacents":[54],"a":[55,159,276,308,370,379,399,432],"terap\u00e8utica,":[58],"facilitant":[59],"identificaci\u00f3":[61],"biomarcadors,":[63],"classificaci\u00f3":[65,292],"pacients":[67,367,384,397,499],"desenvolupament":[70,494],"d'estrat\u00e8gies":[71],"terap\u00e8utiques":[72],"personalitzades.":[73],"es":[76,168,197,241,312,337],"divideix":[77],"tres":[79,422],"estudis":[80,189,440],"independents":[81],"aborden":[83],"diferents":[84],"dimensions":[85,219],"d'aquesta":[86],"hip\u00f2tesi.":[87],"El":[88,265,322,355],"primer":[89],"estudi":[90,267,357],"va":[91,198,242,268,313,326,338,358],"analitzar":[92,199],"els":[93,147,173,177,285,396,474],"canvis":[94],"immunit\u00e0ria":[98],"durant":[99],"tractament":[101,118,203],"una":[103,140,245,328,427,489],"petita":[104],"cohort":[105,428],"d'un":[106],"assaig":[107,373],"cl\u00ednic":[108,374],"aleatoritzat":[109],"(NCT02781909),":[110],"avaluava":[112],"l'\u00fas":[113],"adjuvant":[114],"d'ibuprof\u00e8n":[115],"amb":[116,137,191,244,251,340,376,386,435],"est\u00e0ndard":[119],"casos":[121],"TB":[123],"multiresistent.":[124],"Es":[125,215,299,404],"van":[126,169,216,300,393,405,423],"observar":[127],"reduccions":[128],"significatives":[129],"marcadors":[131],"inflamatoris":[132],"grup":[135],"tractat":[136],"ibuprof\u00e8n,":[138],"incloent-hi":[139],"disminuci\u00f3":[141],"relaci\u00f3":[144],"monocits-limf\u00f2cits,":[145],"nivells":[148],"d'interfer\u00f3":[149],"gamma":[150],"les":[153,333,420,443],"puntuacions":[154],"signatures":[156,270],"associades":[158,431],"al":[162,202,261,493,506],"tractament.":[163,264],"Tot":[164,458],"no":[167],"detectar":[170],"millores":[171],"resultats":[174,253],"cl\u00ednics":[175,502],"primaris,":[176],"efectes":[178],"immunomoduladors":[179],"bon":[182],"seguretat":[185],"l'ibuprof\u00e8n":[187],"justifiquen":[188],"posteriors":[190],"cohorts":[192],"m\u00e9s":[193,248,350,484],"grans.":[194],"A":[195,486],"m\u00e9s,":[196,487],"independentment":[204],"del":[205,228,263,288],"tipus":[206],"d'intervenci\u00f3,":[207],"integrant":[208],"cl\u00edniques,":[210],"biomarcadors":[211,407,483],"plasm\u00e0tics":[212],"transcript\u00f2mics.":[214],"identificar":[217,406,482],"dues":[218],"diferenciades":[220],"progressi\u00f3":[223],"TB:":[226],"l'eliminaci\u00f3":[227],"patogen":[229],"dany":[232],"tissular":[233],"l'hoste.":[235],"Una":[236],"activaci\u00f3":[237],"immune":[238],"basal":[239],"elevada":[240],"associar":[243],"eliminaci\u00f3":[246],"bacteriana":[247],"r\u00e0pida,":[249],"per\u00f2":[250],"pitjors":[252],"patologia":[255],"qualitat":[258],"vida":[260],"final":[262],"segon":[266],"utilitzar":[269],"g\u00e8niques":[271],"simular":[273,314],"inhibidors":[277],"punts":[279],"control":[281],"immunol\u00f2gic":[282],"(ICI)":[283],"subtipus":[286,310,323],"moleculars":[287],"TNBC,":[289],"segons":[290],"Lehmann":[294],"(BL1,":[295],"BL2,":[296],"LAR,":[297],"M).":[298],"construir":[301,363],"models":[302,364,389,496],"xarxes":[304],"proteiques":[305],"espec\u00edfiques":[306],"cada":[309],"propagaci\u00f3":[316],"senyals":[318],"indu\u00efdes":[319],"pels":[320],"ICI.":[321],"mesenquimal":[324],"(M)":[325],"mostrar":[327],"efic\u00e0cia":[329],"significativament":[330],"inferior":[331],"simulacions,":[334],"resultat":[335],"corroborar":[339],"estimacions":[341],"infiltraci\u00f3":[345],"c\u00e8l\u00b7lules":[347],"immunes,":[348],"tamb\u00e9":[349],"baixes":[351],"aquest":[353],"subtipus.":[354],"tercer":[356],"emprar":[359],"digitals":[365,497],"dur":[369],"terme":[371],"un":[372],"virtual":[375],"regorafenib":[377],"com":[378,398],"primera":[380],"l\u00ednia":[381],"399":[383],"grans":[385],"mCRC.":[387],"Els":[388],"xarxa":[391],"personalitzats":[392],"permetre":[394],"classificar":[395],"bons":[400],"o":[401],"mals":[402],"respondents.":[403],"mecan\u00edstics":[408,476],"predictius,":[410],"destacant":[411],"quatre":[412],"prote\u00efnes":[413],"(MARK3,":[414],"RBCK1,":[415],"LHCGR":[416],"HSF1),":[418],"quals":[421],"ser":[424],"validades":[425],"independent":[429],"microARNs":[433],"relacionats":[434],"regorafenib.":[436],"En":[437],"conjunt,":[438],"aquests":[439],"demostren":[441],"poden":[446,479],"difer\u00e8ncies":[448],"biol\u00f2giques":[449],"individuals":[450],"influeixen":[452],"tractaments.":[457],"seva":[462],"aplicaci\u00f3":[463],"cl\u00ednica":[464],"rutin\u00e0ria":[465],"limitada":[467],"complexitat":[470],"cost,":[473],"coneixements":[475],"proporcionen":[478],"aprofitar-se":[480],"accessibles.":[485],"constitueixen":[488],"base":[490],"s\u00f2lida":[491],"assaigs":[501],"in":[503],"silico,":[504],"contribuint":[505],"progr\u00e9s":[507],"l'oncologia":[509],"precisi\u00f3.":[511]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-12-10T00:00:00"}
