{"id":"https://openalex.org/W7111237010","doi":"https://doi.org/10.14309/01.ajg.0001147376.26730.17","title":"S4979 The Use of IVIG in Drug Induced Colitis","display_name":"S4979 The Use of IVIG in Drug Induced Colitis","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W7111237010","doi":"https://doi.org/10.14309/01.ajg.0001147376.26730.17"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0001147376.26730.17","doi":"https://doi.org/10.14309/01.ajg.0001147376.26730.17","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001147376.26730.17","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hyder Said","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hyder Said","raw_affiliation_strings":["Presenter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Presenter","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Serre-Yu Wong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Serre-Yu Wong","raw_affiliation_strings":["Presenter"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Presenter","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"120","issue":"10S2","first_page":"S1063","last_page":"S1063"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.16990000009536743,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.16329999268054962,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-colitis","display_name":"drug-induced colitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/folfirinox","display_name":"FOLFIRINOX","score":0.765999972820282},{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9390000104904175},{"id":"https://openalex.org/keywords/chemotherapy-induced-colitis","display_name":"chemotherapy-induced colitis","score":0.7099999785423279},{"id":"https://openalex.org/keywords/refractory-colitis","display_name":"refractory colitis","score":0.6039999723434448},{"id":"https://openalex.org/keywords/corticosteroid-alternatives","display_name":"corticosteroid alternatives","score":0.5820000171661377},{"id":"https://openalex.org/keywords/colonic-bleeding","display_name":"colonic bleeding","score":0.4779999852180481},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5249999761581421},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.4050000011920929},{"id":"https://openalex.org/keywords/mycophenolate","display_name":"mycophenolate","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9840999841690063},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.5763000249862671},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.5397999882698059},{"id":"https://openalex.org/C2779896975","wikidata":"https://www.wikidata.org/wiki/Q941169","display_name":"Sigmoidoscopy","level":5,"score":0.49309998750686646},{"id":"https://openalex.org/C2776870353","wikidata":"https://www.wikidata.org/wiki/Q677253","display_name":"Sigmoid colon","level":3,"score":0.4867999851703644},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4745999872684479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46560001373291016},{"id":"https://openalex.org/C2777043163","wikidata":"https://www.wikidata.org/wiki/Q1532338","display_name":"Ischemic colitis","level":3,"score":0.45489999651908875},{"id":"https://openalex.org/C3019760618","wikidata":"https://www.wikidata.org/wiki/Q5144815","display_name":"Splenic flexure","level":5,"score":0.446399986743927},{"id":"https://openalex.org/C2776206344","wikidata":"https://www.wikidata.org/wiki/Q837583","display_name":"Carcinosis","level":5,"score":0.4359000027179718},{"id":"https://openalex.org/C2780955771","wikidata":"https://www.wikidata.org/wiki/Q183425","display_name":"Abdominal pain","level":2,"score":0.40959998965263367},{"id":"https://openalex.org/C2780778865","wikidata":"https://www.wikidata.org/wiki/Q1130374","display_name":"Laparotomy","level":2,"score":0.376800000667572},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.35580000281333923},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35120001435279846},{"id":"https://openalex.org/C2778292851","wikidata":"https://www.wikidata.org/wiki/Q2562565","display_name":"Descending colon","level":3,"score":0.3264999985694885},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.31619998812675476},{"id":"https://openalex.org/C2776667177","wikidata":"https://www.wikidata.org/wiki/Q1779148","display_name":"Colectomy","level":4,"score":0.3068999946117401},{"id":"https://openalex.org/C2779983558","wikidata":"https://www.wikidata.org/wiki/Q9597","display_name":"Abdomen","level":2,"score":0.3046000003814697},{"id":"https://openalex.org/C2777068960","wikidata":"https://www.wikidata.org/wiki/Q417874","display_name":"Bisacodyl","level":5,"score":0.2840000092983246},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.267300009727478},{"id":"https://openalex.org/C2779810446","wikidata":"https://www.wikidata.org/wiki/Q941770","display_name":"Proctitis","level":4,"score":0.26489999890327454},{"id":"https://openalex.org/C2780199535","wikidata":"https://www.wikidata.org/wiki/Q223102","display_name":"Peritonitis","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C2780120127","wikidata":"https://www.wikidata.org/wiki/Q743664","display_name":"Abdominal surgery","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2779753318","wikidata":"https://www.wikidata.org/wiki/Q160796","display_name":"Delirium","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C2778582513","wikidata":"https://www.wikidata.org/wiki/Q2099990","display_name":"Pneumatosis intestinalis","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0001147376.26730.17","doi":"https://doi.org/10.14309/01.ajg.0001147376.26730.17","is_oa":false,"landing_page_url":"https://doi.org/10.14309/01.ajg.0001147376.26730.17","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.866059422492981,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Drug-induced":[1],"colitis":[2,9,273],"(DiC)":[3],"accounts":[4],"for":[5,335],"\u223c10%":[6],"of":[7,38,55,168,235,290],"new":[8],"cases.":[10],"While":[11],"often":[12,265],"linked":[13],"to":[14,122,257,293,343],"NSAIDs,":[15],"immune":[16,270],"checkpoint":[17,271],"inhibitors,":[18],"and":[19,62,83,102,116,131,137,147,154,174,197,213,269,305,318,347],"mycophenolate,":[20],"many":[21],"other":[22],"agents":[23],"have":[24],"also":[25],"been":[26],"implicated.":[27],"Evidence":[28],"regarding":[29],"DiC":[30,40,206,236,262,350],"management":[31],"is":[32,207,264,300],"limited.":[33,232,325],"We":[34],"report":[35],"a":[36,117,332],"case":[37,327],"severe":[39],"treated":[41],"successfully":[42],"with":[43,52,59,141,164,210],"intravenous":[44],"immunoglobulin":[45],"(IVIG).":[46],"Case":[47],"Description/Methods:":[48],"A":[49,90],"58-year-old":[50],"man":[51],"metastatic":[53],"adenocarcinoma":[54],"unknown":[56],"primary":[57],"presented":[58],"abdominal":[60],"pain":[61],"emesis":[63],"1":[64,202],"month":[65],"after":[66],"FOLFIRINOX":[67],"initiation.":[68],"Computed":[69],"tomography":[70],"showed":[71,134,161],"large":[72],"bowel":[73],"obstruction":[74],"at":[75],"the":[76,88,129],"splenic":[77],"flexure.":[78],"Laparotomy":[79],"revealed":[80,125],"peritoneal":[81],"carcinomatosis":[82],"an":[84],"extrinsic":[85],"mass":[86],"compressing":[87],"colon.":[89],"colo-colonic":[91],"bypass":[92],"was":[93,189,200,287],"performed.":[94],"Post-operatively,":[95],"he":[96,107],"developed":[97,108],"intra-abdominal":[98],"abscesses":[99],"requiring":[100],"drainage":[101],"antibiotics.":[103],"On":[104],"day":[105],"20,":[106],"hematochezia,":[109],"hemodynamic":[110],"instability":[111],"(HR":[112],"118,":[113],"BP":[114],"90/55),":[115],"hemoglobin":[118],"drop":[119],"from":[120,267],"9.2":[121],"6.9.":[123],"Sigmoidoscopy":[124],"multifocal":[126],"ulcerations":[127],"in":[128,303,315,349],"sigmoid":[130],"rectum.":[132],"Histology":[133],"crypt":[135],"dropout":[136],"increased":[138],"apoptosis,":[139],"consistent":[140],"DiC.":[142,169,338],"Medication":[143],"review":[144],"identified":[145],"5-FU":[146],"oxaliplatin":[148],"as":[149],"potential":[150],"culprits.":[151],"Despite":[152],"cessation":[153,212],"supportive":[155,214],"care,":[156],"bleeding":[157],"recurred.":[158],"Repeat":[159],"colonoscopy":[160],"diffuse":[162],"ulceration":[163],"ongoing":[165],"histologic":[166],"evidence":[167],"Given":[170,250],"his":[171],"critical":[172],"condition":[173],"recent":[175],"infections,":[176],"corticosteroids":[177,219,291],"were":[178],"deferred.":[179],"After":[180],"multidisciplinary":[181],"discussion,":[182],"IVIG":[183,286,299,310,329],"(1":[184],"g/kg":[185],"\u00d7":[186],"2":[187],"days)":[188],"administered.":[190],"Within":[191],"48":[192],"hours,":[193],"stools":[194],"became":[195],"non-bloody":[196],"formed.":[198],"He":[199],"discharged":[201],"week":[203],"later.":[204],"Discussion:":[205],"typically":[208],"managed":[209],"drug":[211],"care.":[215],"In":[216,260,283,308],"refractory":[217,316],"cases,":[218],"may":[220,241,278,330],"be":[221,281,331],"used,":[222],"but":[223,240],"data":[224,323],"on":[225],"alternatives":[226],"when":[227],"steroids":[228],"are":[229,231,341],"contraindicated":[230],"The":[233],"pathophysiology":[234],"remains":[237],"poorly":[238],"understood":[239],"involve":[242],"mucosal":[243],"cytotoxicity,":[244],"barrier":[245],"disruption,":[246],"or":[247],"ischemia-like":[248],"injury.":[249],"this":[251,284],"mechanistic":[252],"heterogeneity,":[253],"limited":[254],"research":[255],"exists":[256],"guide":[258],"therapy.":[259],"practice,":[261],"treatment":[263],"extrapolated":[266],"IBD":[268,317],"inhibitors":[272],"literature,":[274],"though":[275,322],"these":[276],"approaches":[277],"not":[279],"always":[280],"appropriate.":[282],"case,":[285],"used":[288,302],"instead":[289],"due":[292],"its":[294,345],"relatively":[295],"low":[296],"immunosuppressive":[297],"profile.":[298],"commonly":[301],"immunodeficiency":[304],"immune-mediated":[306],"diseases.":[307],"gastroenterology,":[309],"has":[311],"shown":[312],"some":[313],"success":[314],"C.":[319],"difficile":[320],"colitis,":[321],"remain":[324],"This":[326],"suggests":[328],"viable":[333],"option":[334],"severe,":[336],"steroid-contraindicated":[337],"Further":[339],"studies":[340],"needed":[342],"clarify":[344],"safety":[346],"efficacy":[348],"management.":[351]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-12-10T00:00:00"}