{"id":"https://openalex.org/W7108359341","doi":"https://doi.org/10.18103/mra.v13i11.7064","title":"Essential Oil-Mediated Potentiation of Erythromycin Against Resistant and Sensitive Cutibacterium acnes: Implications for Antimicrobial Resistance Management","display_name":"Essential Oil-Mediated Potentiation of Erythromycin Against Resistant and Sensitive Cutibacterium acnes: Implications for Antimicrobial Resistance Management","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W7108359341","doi":"https://doi.org/10.18103/mra.v13i11.7064"},"language":"en","primary_location":{"id":"doi:10.18103/mra.v13i11.7064","doi":"https://doi.org/10.18103/mra.v13i11.7064","is_oa":true,"landing_page_url":"https://doi.org/10.18103/mra.v13i11.7064","pdf_url":"https://esmed.org/MRA/mra/article/download/7064/99193549707","source":{"id":"https://openalex.org/S2764661345","display_name":"Medical Research Archives","issn_l":"2375-1916","issn":["2375-1916","2375-1924"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4376882788","host_organization_name":"European Society of Medicine","host_organization_lineage":["https://openalex.org/P4376882788"],"host_organization_lineage_names":["European Society of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research Archives","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://esmed.org/MRA/mra/article/download/7064/99193549707","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030034508","display_name":"Suzanne M. A. Abdelmalek","orcid":"https://orcid.org/0000-0001-5401-6532","observed_orcids":["https://orcid.org/0000-0001-5401-6532"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Suzanne Abdelmalek","raw_affiliation_strings":["Department of Pharmacology and Biomedical Sciences. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan"],"raw_orcid":"https://orcid.org/0000-0001-5401-6532","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Biomedical Sciences. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yehya Al-Banna","orcid":"https://orcid.org/0000-0003-2277-6371","observed_orcids":["https://orcid.org/0000-0003-2277-6371"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Yehya Al-Banna","raw_affiliation_strings":["Department of Pharmacology and Biomedical Sciences. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan"],"raw_orcid":"https://orcid.org/0000-0003-2277-6371","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Biomedical Sciences. Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Malak Hajar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201726411","display_name":"United Arab Emirates University","ror":"https://ror.org/01km6p862","country_code":"AE","type":"education","lineage":["https://openalex.org/I201726411"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Malak Hajar","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, College of Medical and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, College of Medical and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates","institution_ids":["https://openalex.org/I201726411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044224311","display_name":"Kenza Mansoor","orcid":"https://orcid.org/0000-0002-8171-2055","observed_orcids":["https://orcid.org/0000-0002-8171-2055"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Kenza Mansoor","raw_affiliation_strings":["Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences University of Petra, Amman, Jordan"],"raw_orcid":"https://orcid.org/0000-0002-8171-2055","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy and Medical Sciences University of Petra, Amman, Jordan","institution_ids":["https://openalex.org/I36622005"]}]},{"author_position":"last","author":{"id":null,"display_name":"Phillip J. Collier","orcid":"https://orcid.org/0000-0001-8529-2548","observed_orcids":["https://orcid.org/0000-0001-8529-2548"]},"institutions":[{"id":"https://openalex.org/I36622005","display_name":"Petra University","ror":"https://ror.org/039d9es10","country_code":"JO","type":"education","lineage":["https://openalex.org/I36622005"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Phillip J. Collier","raw_affiliation_strings":["Visiting Professor of Pharmaceutical Microbiology, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan"],"raw_orcid":"https://orcid.org/0000-0001-8529-2548","affiliations":[{"raw_affiliation_string":"Visiting Professor of Pharmaceutical Microbiology, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan","institution_ids":["https://openalex.org/I36622005"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3438,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49913286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"13","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.20980000495910645,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cutibacterium-acnes","display_name":"Propionibacterium acnes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/erythromycin","display_name":"erythromycin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tea-tree-oil","display_name":"tea tree oil","score":0.9300000071525574},{"id":"https://openalex.org/keywords/chamomile-oil","display_name":"chamomile essential oil","score":0.9980000257492065},{"id":"https://openalex.org/keywords/essential-oils","display_name":"essential oils","score":0.9559999704360962},{"id":"https://openalex.org/keywords/antibiotic-synergy","display_name":"antibiotic synergy","score":0.7360000014305115},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.8069999814033508},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.996999979019165},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/topical-antimicrobials","display_name":"topical antimicrobial agents","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.9126999974250793},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.7530999779701233},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.633400022983551},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.621399998664856},{"id":"https://openalex.org/C2779168147","wikidata":"https://www.wikidata.org/wiki/Q460711","display_name":"Checkerboard","level":2,"score":0.5946000218391418},{"id":"https://openalex.org/C2775839739","wikidata":"https://www.wikidata.org/wiki/Q48832","display_name":"Tea tree oil","level":3,"score":0.5846999883651733},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.550000011920929},{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.5252000093460083},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5059000253677368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43849998712539673},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.4327999949455261},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39879998564720154},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.3756999969482422},{"id":"https://openalex.org/C2777278459","wikidata":"https://www.wikidata.org/wiki/Q170885","display_name":"Essential oil","level":2,"score":0.3619999885559082},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.35089999437332153},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29100000858306885},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.2669000029563904},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2646999955177307}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18103/mra.v13i11.7064","doi":"https://doi.org/10.18103/mra.v13i11.7064","is_oa":true,"landing_page_url":"https://doi.org/10.18103/mra.v13i11.7064","pdf_url":"https://esmed.org/MRA/mra/article/download/7064/99193549707","source":{"id":"https://openalex.org/S2764661345","display_name":"Medical Research Archives","issn_l":"2375-1916","issn":["2375-1916","2375-1924"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4376882788","host_organization_name":"European Society of Medicine","host_organization_lineage":["https://openalex.org/P4376882788"],"host_organization_lineage_names":["European Society of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research Archives","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18103/mra.v13i11.7064","doi":"https://doi.org/10.18103/mra.v13i11.7064","is_oa":true,"landing_page_url":"https://doi.org/10.18103/mra.v13i11.7064","pdf_url":"https://esmed.org/MRA/mra/article/download/7064/99193549707","source":{"id":"https://openalex.org/S2764661345","display_name":"Medical Research Archives","issn_l":"2375-1916","issn":["2375-1916","2375-1924"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4376882788","host_organization_name":"European Society of Medicine","host_organization_lineage":["https://openalex.org/P4376882788"],"host_organization_lineage_names":["European Society of Medicine"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Research Archives","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319684","display_name":"University of Petra","ror":"https://ror.org/039d9es10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7108359341.pdf","grobid_xml":"https://content.openalex.org/works/W7108359341.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1998144171","https://openalex.org/W2008748583","https://openalex.org/W2013756165","https://openalex.org/W2027936604","https://openalex.org/W2038285085","https://openalex.org/W2077430077","https://openalex.org/W2082006941","https://openalex.org/W2095077363","https://openalex.org/W2113676007","https://openalex.org/W2114677484","https://openalex.org/W2126405942","https://openalex.org/W2128273729","https://openalex.org/W2133763626","https://openalex.org/W2183605265","https://openalex.org/W2319262142","https://openalex.org/W2326823588","https://openalex.org/W2328500304","https://openalex.org/W2553566670","https://openalex.org/W2913408298","https://openalex.org/W2991534909","https://openalex.org/W3024428196","https://openalex.org/W3098142113","https://openalex.org/W3128206046","https://openalex.org/W3160125093","https://openalex.org/W4205965180","https://openalex.org/W4309089724","https://openalex.org/W4385577841"],"related_works":["https://openalex.org/W2580428583","https://openalex.org/W2621218442","https://openalex.org/W2888924355","https://openalex.org/W2789536748","https://openalex.org/W3154752222","https://openalex.org/W4403058447","https://openalex.org/W2095218865","https://openalex.org/W7132432586","https://openalex.org/W2990705674","https://openalex.org/W2548362531"],"abstract_inverted_index":{"Acne":[0,152],"vulgaris,":[1],"a":[2,34,116],"chronic":[3],"skin":[4],"condition,":[5,25],"is,":[6],"in":[7,86,122],"part,":[8],"caused":[9],"by":[10],"the":[11,42,100,134],"bacteria":[12],"Cutibacterium":[13],"acnes":[14,72],"(C.":[15],"acnes).":[16],"Antibiotics":[17],"are":[18],"commonly":[19],"used":[20],"for":[21,33],"treatment":[22],"of":[23,46,59,64,70,79,108,124],"this":[24,130],"but":[26],"antibiotic":[27,131],"resistance":[28],"poses":[29],"an":[30],"increasing":[31],"challenge":[32],"successful":[35],"outcome.":[36],"This":[37],"study":[38],"aims":[39],"to":[40,150],"investigate":[41],"synergistic":[43],"antimicrobial":[44],"activity":[45,132],"tea":[47],"tree":[48],"oil":[49,52,143],"(TTO),":[50],"chamomile":[51],"(CO),":[53],"with":[54,113,146],"erythromycin":[55,83,114,125],"against":[56],"clinical":[57,68],"strains":[58,63],"erythromycin-sensitive":[60],"and":[61,82,85,92,110],"erythromycin-resistant":[62,135],"C.":[65,71,136],"acnes.":[66,137],"Twenty-one":[67],"samples":[69],"were":[73,88,97],"used.":[74],"Minimum":[75],"inhibitory":[76],"concentrations":[77],"(MIC)":[78],"TTO,":[80],"CO,":[81],"alone":[84],"combination":[87],"investigated":[89],"using":[90,99,141],"microdilution":[91],"checkerboard":[93],"assays.":[94],"Synergistic":[95],"interactions":[96],"evaluated":[98],"Fraction":[101],"Inhibitory":[102],"Concentration":[103],"Index":[104],"(FICI).":[105],"The":[106],"mixture":[107],"TTO":[109],"CO":[111],"combined":[112],"showed":[115],"significant":[117],"95.97":[118],"%":[119],"(P<0.05)":[120],"reduction":[121],"MIC":[123],"(FICI":[126],"=":[127],"0.13),":[128],"restoring":[129],"on":[133],"These":[138],"results":[139],"suggest":[140],"essential":[142],"combinations":[144],"simultaneously":[145],"conventional":[147],"topical":[148],"antimicrobials":[149],"treat":[151],"vulgaris.":[153]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-12-03T00:00:00"}