{"id":"https://openalex.org/W7108317805","doi":"https://doi.org/10.5281/zenodo.17786372","title":"Development of Myelinating Human Brain Organoids for Modelling Multiple Sclerosis: A Platform For Drug Screening Studies and Mechanistic Investigations","display_name":"Development of Myelinating Human Brain Organoids for Modelling Multiple Sclerosis: A Platform For Drug Screening Studies and Mechanistic Investigations","publication_year":2025,"publication_date":"2025-08-05","ids":{"openalex":"https://openalex.org/W7108317805","doi":"https://doi.org/10.5281/zenodo.17786372"},"language":"en","primary_location":{"id":"pmh:oai:dergipark.org.tr:article/1704595","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/ejmbs/article/1704595","pdf_url":null,"source":{"id":"https://openalex.org/S4387284448","display_name":"Erzurum Technical University","issn_l":"2822-4019","issn":["2822-4019"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I265519392","host_organization_name":"Erzurum Technical University","host_organization_lineage":["https://openalex.org/I265519392"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://dergipark.org.tr/en/pub/ejmbs/article/1704595","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114434186","display_name":"B\u00fc\u015fra Acar","orcid":"https://orcid.org/0000-0002-4772-2698","observed_orcids":["https://orcid.org/0000-0002-4772-2698"]},"institutions":[{"id":"https://openalex.org/I95293974","display_name":"Abdullah G\u00fcl University","ror":"https://ror.org/00zdyy359","country_code":"TR","type":"education","lineage":["https://openalex.org/I95293974"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Acar, B\u00fc\u015fra","raw_affiliation_strings":["Abdullah G\u00fcl University"],"raw_orcid":"https://orcid.org/0000-0002-4772-2698","affiliations":[{"raw_affiliation_string":"Abdullah G\u00fcl University","institution_ids":["https://openalex.org/I95293974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013712666","display_name":"Alaattin \u015een","orcid":"https://orcid.org/0000-0002-8444-376X","observed_orcids":["https://orcid.org/0000-0002-8444-376X"]},"institutions":[{"id":"https://openalex.org/I48843708","display_name":"Pamukkale University","ror":"https://ror.org/01etz1309","country_code":"TR","type":"education","lineage":["https://openalex.org/I48843708"]},{"id":"https://openalex.org/I95293974","display_name":"Abdullah G\u00fcl University","ror":"https://ror.org/00zdyy359","country_code":"TR","type":"education","lineage":["https://openalex.org/I95293974"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u015een, Alaattin","raw_affiliation_strings":["Abdullah G\u00fcl University","Pamukkale University"],"raw_orcid":"https://orcid.org/0000-0002-8444-376X","affiliations":[{"raw_affiliation_string":"Abdullah G\u00fcl University","institution_ids":["https://openalex.org/I95293974"]},{"raw_affiliation_string":"Pamukkale University","institution_ids":["https://openalex.org/I48843708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/brain-organoids","display_name":"brain organoids","score":0.9559999704360962},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.8489999771118164},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.9279999732971191},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.8019999861717224},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.9330000281333923},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7409999966621399},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8019999861717224},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cnpase","display_name":"CNPase","score":0.722000002861023},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9190000295639038},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/disease-modeling","display_name":"disease modeling","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.965499997138977},{"id":"https://openalex.org/C2776036978","wikidata":"https://www.wikidata.org/wiki/Q425137","display_name":"Fingolimod","level":3,"score":0.7558000087738037},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.6283000111579895},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5852000117301941},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5092999935150146},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.48429998755455017},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.47679999470710754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4620000123977661},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4287000000476837},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4027999937534332},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36090001463890076},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.35580000281333923},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3163999915122986},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.3091000020503998},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3075000047683716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28600001335144043},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2825999855995178},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.272599995136261},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2702000141143799},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.2612999975681305},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:dergipark.org.tr:article/1704595","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/ejmbs/article/1704595","pdf_url":null,"source":{"id":"https://openalex.org/S4387284448","display_name":"Erzurum Technical University","issn_l":"2822-4019","issn":["2822-4019"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I265519392","host_organization_name":"Erzurum Technical University","host_organization_lineage":["https://openalex.org/I265519392"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.5281/zenodo.17786372","doi":"https://doi.org/10.5281/zenodo.17786372","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17786372","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.17786373","doi":"https://doi.org/10.5281/zenodo.17786373","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17786373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.17786454","doi":"https://doi.org/10.5281/zenodo.17786454","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.17786454","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:dergipark.org.tr:article/1704595","doi":null,"is_oa":true,"landing_page_url":"https://dergipark.org.tr/en/pub/ejmbs/article/1704595","pdf_url":null,"source":{"id":"https://openalex.org/S4387284448","display_name":"Erzurum Technical University","issn_l":"2822-4019","issn":["2822-4019"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I265519392","host_organization_name":"Erzurum Technical University","host_organization_lineage":["https://openalex.org/I265519392"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415210571","https://openalex.org/W4401419626","https://openalex.org/W7030512006","https://openalex.org/W4414110387","https://openalex.org/W4389366612","https://openalex.org/W4405558863","https://openalex.org/W3137017910","https://openalex.org/W4394600566","https://openalex.org/W4389446484","https://openalex.org/W7213581360"],"abstract_inverted_index":{"Multiple":[0],"sclerosis":[1],"(MS)":[2],"is":[3,8],"a":[4,227],"neurodegenerative":[5],"disease":[6,35],"that":[7,191],"characterized":[9],"mainly":[10],"by":[11,130,149,195,206],"demyelination":[12,140],"and":[13,24,41,61,83,104,122,139,158,187,199,217,243],"inflammation.":[14],"The":[15,115,144],"disadvantages":[16],"of":[17,33,117,168,180,203,213],"the":[18,28,31,46,51,100,126,166,171,201,209],"current":[19],"two-dimensional":[20],"cell":[21],"culture":[22],"models":[23,52],"experimental":[25],"animals":[26],"imply":[27],"need":[29],"for":[30,44,56,86,232,238],"development":[32],"new":[34],"models.":[36],"Brain":[37],"organoids":[38,85,110,127,169,189],"are":[39,65],"emerging":[40],"powerful":[42],"tools":[43],"recapitulating":[45],"central":[47],"nervous":[48],"system.":[49],"Although":[50],"have":[53],"been":[54],"generated":[55,237],"many":[57],"years,":[58],"time-consuming":[59],"processes":[60],"less":[62],"cellular":[63],"diversity":[64],"important":[66],"challenges":[67],"in":[68,125,156,162,170,240],"defined":[69],"protocols.":[70],"In":[71,88,225],"this":[72],"study,":[73],"we":[74],"aimed":[75],"to":[76,97,107,136],"generate":[77,108],"an":[78,153,159],"optimized":[79],"brain":[80,109,229],"organoid":[81,230],"protocol":[82],"model":[84,145,231],"MS.":[87],"these":[89],"processes,":[90],"human":[91,228],"embryonic":[92],"stem":[93],"cells":[94,205],"were":[95,222],"directed":[96],"neurons":[98,124],"via":[99,141,177],"extracellular":[101],"matrix":[102],"(ECM)":[103],"growth":[105],"factors":[106],"with":[111],"diverse":[112],"neural":[113],"cells.":[114,164],"presence":[116],"myelinating":[118],"cells,":[119],"astrocytes,":[120],"microglia":[121],"excitatory":[123],"was":[128,133,146,175,235],"verified":[129],"immunostaining.":[131],"MS":[132,233],"then":[134],"used":[135],"induce":[137],"inflammation":[138],"lipopolysaccharide":[142],"(LPS).":[143],"also":[147],"confirmed":[148],"immunostaining,":[150],"which":[151],"revealed":[152,190],"~50%":[154],"increase":[155],"GFAP":[157,194],"~60%":[160],"decrease":[161],"CNPase-positive":[163,204],"Finally,":[165],"use":[167,239],"drug":[172,241],"screening":[173,242],"field":[174],"tested":[176],"fingolimod":[178,192,220],"treatment":[179,221],"LPS-induced":[181],"organoids.":[182],"A":[183],"comparison":[184],"between":[185],"fingolimod-treated":[186],"untreated":[188],"decreased":[193],"more":[196],"than":[197],"80%":[198],"increased":[200],"percentage":[202],"90%.":[207],"Additionally,":[208],"relative":[210],"expression":[211],"levels":[212],"inflammation-related":[214],"transcripts":[215],"(FOXP3":[216],"GFAP)":[218],"after":[219],"significantly":[223],"decreased.":[224],"conclusion,":[226],"studies":[234],"successfully":[236],"mechanistic":[244],"studies.":[245]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-12-03T00:00:00"}
