{"id":"https://openalex.org/W7106239782","doi":"https://doi.org/10.1016/j.ocarto.2026.100889","title":"The role of radiographic knee alignment in total knee replacement outcomes and opportunities for artificial intelligence-driven assessment","display_name":"The role of radiographic knee alignment in total knee replacement outcomes and opportunities for artificial intelligence-driven assessment","publication_year":2026,"publication_date":"2026-10-16","ids":{"openalex":"https://openalex.org/W7106239782","doi":"https://doi.org/10.1016/j.ocarto.2026.100889","pmid":"https://pubmed.ncbi.nlm.nih.gov/42959533","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13717176"},"language":"en","primary_location":{"id":"doi:10.1016/j.ocarto.2026.100889","doi":"https://doi.org/10.1016/j.ocarto.2026.100889","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ocarto.2026.100889","pdf_url":null,"source":{"id":"https://openalex.org/S4210208012","display_name":"Osteoarthritis and Cartilage Open","issn_l":"2665-9131","issn":["2665-9131"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ocarto.2026.100889","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhisen Hu","orcid":"https://orcid.org/0009-0008-1065-6480","observed_orcids":["https://orcid.org/0009-0008-1065-6480"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zhisen Hu","raw_affiliation_strings":["Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK"],"raw_orcid":"https://orcid.org/0009-0008-1065-6480","affiliations":[{"raw_affiliation_string":"Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dominic Cullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4405259061","display_name":"Northern Care Alliance NHS Foundation Trust","ror":"https://ror.org/01nqeyn25","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4405259061"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dominic Cullen","raw_affiliation_strings":["Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK","Northern Care Alliance NHS Foundation Trust, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"Northern Care Alliance NHS Foundation Trust, UK","institution_ids":["https://openalex.org/I4405259061"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David S. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802561160","display_name":"Stepping Hill Hospital","ror":"https://ror.org/02dvgss50","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802561160","https://openalex.org/I4210114233"]},{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210114233","display_name":"Stockport NHS Foundation Trust","ror":"https://ror.org/0220rp185","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210114233"]},{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"David S. Johnson","raw_affiliation_strings":["Department of Trauma and Orthopaedics, Stockport NHS Foundation Trust, Stepping Hill Hospital, UK","School of Biological Sciences, The University of Manchester, UK","School of Health and Society, University of Salford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Trauma and Orthopaedics, Stockport NHS Foundation Trust, Stepping Hill Hospital, UK","institution_ids":["https://openalex.org/I2802561160","https://openalex.org/I4210114233"]},{"raw_affiliation_string":"School of Biological Sciences, The University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]},{"raw_affiliation_string":"School of Health and Society, University of Salford, UK","institution_ids":["https://openalex.org/I54459138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051498728","display_name":"Aleksei Tiulpin","orcid":"https://orcid.org/0000-0002-7852-4141","observed_orcids":["https://orcid.org/0000-0002-7852-4141"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI","US"],"is_corresponding":true,"raw_author_name":"Aleksei Tiulpin","raw_affiliation_strings":["Research Unit of Health Sciences and Technology, University of Oulu, Finland","Weill Cornell Medicine, Cornell University, USA"],"raw_orcid":"https://orcid.org/0000-0002-7852-4141","affiliations":[{"raw_affiliation_string":"Research Unit of Health Sciences and Technology, University of Oulu, Finland","institution_ids":["https://openalex.org/I98381234"]},{"raw_affiliation_string":"Weill Cornell Medicine, Cornell University, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Timothy F. Cootes","orcid":"https://orcid.org/0000-0002-2695-9063","observed_orcids":["https://orcid.org/0000-0002-2695-9063"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Timothy F. Cootes","raw_affiliation_strings":["Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0002-2695-9063","affiliations":[{"raw_affiliation_string":"Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010012669","display_name":"Claudia Lindner","orcid":"https://orcid.org/0000-0001-9396-3436","observed_orcids":["https://orcid.org/0000-0001-9396-3436","https://orcid.org/0000-0001-5318-7997"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Claudia Lindner","raw_affiliation_strings":["Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK"],"raw_orcid":"https://orcid.org/0000-0001-9396-3436","affiliations":[{"raw_affiliation_string":"Department of Informatics, Imaging and Data Sciences, The University of Manchester, UK","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5010012669","https://openalex.org/A5051498728"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I2802561160","https://openalex.org/I28407311","https://openalex.org/I4210114233","https://openalex.org/I4387153466","https://openalex.org/I4405259061","https://openalex.org/I54459138","https://openalex.org/I98381234"],"apc_list":{"value":1610,"currency":"USD","value_usd":1610},"apc_paid":{"value":1610,"currency":"USD","value_usd":1610},"fwci":4.8439,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.88550065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"8","issue":"4","first_page":"100889","last_page":"100889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10562","display_name":"Total Knee Arthroplasty Outcomes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11636","display_name":"Artificial Intelligence in Healthcare and Education","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2718","display_name":"Health Informatics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10442","display_name":"Knee injuries and reconstruction techniques","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-knee-arthroplasty","display_name":"total knee arthroplasty","score":0.8640000224113464},{"id":"https://openalex.org/keywords/knee-alignment","display_name":"knee alignment","score":0.6449999809265137},{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"artificial intelligence","score":0.953000009059906},{"id":"https://openalex.org/keywords/knee-radiographs","display_name":"knee radiographs","score":0.8569999933242798},{"id":"https://openalex.org/keywords/postoperative-outcomes","display_name":"postoperative outcomes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.9399999976158142},{"id":"https://openalex.org/keywords/surgical-planning","display_name":"surgical planning","score":0.8190000057220459},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9639999866485596},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9006999731063843},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.772599995136261},{"id":"https://openalex.org/C36454342","wikidata":"https://www.wikidata.org/wiki/Q245341","display_name":"Radiography","level":2,"score":0.6904000043869019},{"id":"https://openalex.org/C2986595273","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee replacement","level":2,"score":0.6266000270843506},{"id":"https://openalex.org/C2778715743","wikidata":"https://www.wikidata.org/wiki/Q181802","display_name":"Prosthesis","level":2,"score":0.5903000235557556},{"id":"https://openalex.org/C2778104916","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Knee replacement","level":3,"score":0.5126000046730042},{"id":"https://openalex.org/C2778336525","wikidata":"https://www.wikidata.org/wiki/Q708178","display_name":"Arthroplasty","level":2,"score":0.4912000000476837},{"id":"https://openalex.org/C2908736133","wikidata":"https://www.wikidata.org/wiki/Q37425","display_name":"Knee Joint","level":2,"score":0.415800005197525},{"id":"https://openalex.org/C3017871827","wikidata":"https://www.wikidata.org/wiki/Q1693864","display_name":"Total knee arthroplasty","level":2,"score":0.4138000011444092},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4050000011920929},{"id":"https://openalex.org/C3019066406","wikidata":"https://www.wikidata.org/wiki/Q64138885","display_name":"Knee prosthesis","level":3,"score":0.40070000290870667},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.3783999979496002},{"id":"https://openalex.org/C2779146052","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Arthropathy","level":4,"score":0.36559998989105225},{"id":"https://openalex.org/C2777417762","wikidata":"https://www.wikidata.org/wiki/Q1863402","display_name":"Joint replacement","level":3,"score":0.3617999851703644},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.337799996137619},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C2780463824","wikidata":"https://www.wikidata.org/wiki/Q7115567","display_name":"Oxford knee score","level":4,"score":0.2646999955177307},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.25760000944137573}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.ocarto.2026.100889","doi":"https://doi.org/10.1016/j.ocarto.2026.100889","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ocarto.2026.100889","pdf_url":null,"source":{"id":"https://openalex.org/S4210208012","display_name":"Osteoarthritis and Cartilage Open","issn_l":"2665-9131","issn":["2665-9131"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13717176","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717176/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13717176/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthr Cartil Open","raw_type":"Text"},{"id":"pmid:42959533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42959533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and cartilage open","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:2508.10941","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2508.10941","pdf_url":"https://arxiv.org/pdf/2508.10941","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d6471155e7ab497380fd7edc99159d7b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d6471155e7ab497380fd7edc99159d7b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Osteoarthritis and Cartilage Open, Vol 8, Iss 4, Pp 100889- (2026)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/ed5e6b81-a499-4a5d-b2a6-596341d80a49","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/ed5e6b81-a499-4a5d-b2a6-596341d80a49","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Hu, Z, Cullen, D, Johnson, D S, Tiulpin, A, Cootes, T F & Lindner, C 2026, 'The role of radiographic knee alignment in total knee replacement outcomes and opportunities for artificial intelligence-driven assessment', Osteoarthritis and Cartilage Open, vol. 8, no. 4, 100889. https://doi.org/10.1016/j.ocarto.2026.100889","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.48550/arxiv.2508.10941","doi":"https://doi.org/10.48550/arxiv.2508.10941","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2508.10941","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1016/j.ocarto.2026.100889","doi":"https://doi.org/10.1016/j.ocarto.2026.100889","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ocarto.2026.100889","pdf_url":null,"source":{"id":"https://openalex.org/S4210208012","display_name":"Osteoarthritis and Cartilage Open","issn_l":"2665-9131","issn":["2665-9131"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage Open","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8214455224","display_name":"Developing a software system to improve the management and outcome of knee replacement surgery by combining radiographic image information with clinical and patient data","funder_award_id":"223267","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7106239782.pdf","grobid_xml":"https://content.openalex.org/works/W7106239782.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1563795667","https://openalex.org/W1975381839","https://openalex.org/W1978190869","https://openalex.org/W1989171659","https://openalex.org/W2001992768","https://openalex.org/W2007075548","https://openalex.org/W2007535907","https://openalex.org/W2009621568","https://openalex.org/W2020842346","https://openalex.org/W2038952578","https://openalex.org/W2055493458","https://openalex.org/W2080417058","https://openalex.org/W2103307204","https://openalex.org/W2106512482","https://openalex.org/W2111088881","https://openalex.org/W2114128492","https://openalex.org/W2134175790","https://openalex.org/W2152826865","https://openalex.org/W2273589933","https://openalex.org/W2274722622","https://openalex.org/W2763155066","https://openalex.org/W2900360553","https://openalex.org/W2902433159","https://openalex.org/W2903819949","https://openalex.org/W2911964244","https://openalex.org/W2916845318","https://openalex.org/W2919115771","https://openalex.org/W2921406441","https://openalex.org/W3002114029","https://openalex.org/W3014641072","https://openalex.org/W3018757597","https://openalex.org/W3019670539","https://openalex.org/W3021106503","https://openalex.org/W3021286010","https://openalex.org/W3024907164","https://openalex.org/W3095822998","https://openalex.org/W3114674742","https://openalex.org/W3124994365","https://openalex.org/W3150363874","https://openalex.org/W3151219028","https://openalex.org/W3197831186","https://openalex.org/W3213209526","https://openalex.org/W4213231055","https://openalex.org/W4214749059","https://openalex.org/W4220730969","https://openalex.org/W4285077557","https://openalex.org/W4293036647","https://openalex.org/W4294811304","https://openalex.org/W4294991429","https://openalex.org/W4301394185","https://openalex.org/W4304690545","https://openalex.org/W4306181042","https://openalex.org/W4362661579","https://openalex.org/W4367294659","https://openalex.org/W4377969241","https://openalex.org/W4381149672","https://openalex.org/W4384626521","https://openalex.org/W4386475171","https://openalex.org/W4388680582","https://openalex.org/W4388774248","https://openalex.org/W4391317367","https://openalex.org/W4392558936","https://openalex.org/W4392576551","https://openalex.org/W4392861990","https://openalex.org/W4399247246","https://openalex.org/W4400429759","https://openalex.org/W4400881081","https://openalex.org/W4401819803","https://openalex.org/W4402576525","https://openalex.org/W4403574341","https://openalex.org/W4404858252","https://openalex.org/W4404881059","https://openalex.org/W4408119296","https://openalex.org/W4409715443"],"related_works":["https://openalex.org/W6908657317","https://openalex.org/W4392773151","https://openalex.org/W7160624399","https://openalex.org/W4392673270","https://openalex.org/W3039247340","https://openalex.org/W7133333290","https://openalex.org/W4366979399","https://openalex.org/W4415000337","https://openalex.org/W2032265308","https://openalex.org/W7128496359"],"abstract_inverted_index":{"Prevalent":[0],"knee":[1,19,38,65,71,103,148,163,167,175],"osteoarthritis":[2],"(OA)":[3],"imposes":[4],"substantial":[5],"burden":[6],"on":[7],"health":[8],"systems":[9,231],"with":[10,91,152],"no":[11],"cure":[12],"available.":[13],"Its":[14],"ultimate":[15],"treatment":[16],"is":[17,40,97],"total":[18],"replacement":[20],"(TKR).":[21],"Complications":[22],"from":[23,166],"surgery":[24],"and":[25,31,85,114,122,128,146,169,178,208,222,230,244],"recovery":[26],"are":[27,106,239],"difficult":[28],"to":[29,62,69,100,111,204,236,241],"predict,":[30],"numerous":[32],"factors":[33],"may":[34,118],"affect":[35],"them.":[36],"Radiographic":[37],"alignment":[39,88,104,149,164,176,183,234],"a":[41,201],"key":[42],"factor":[43],"affecting":[44,47],"TKR":[45,112,144,179,195],"success,":[46],"outcomes":[48,145],"such":[49],"as":[50],"postoperative":[51,92],"pain":[52],"or":[53],"function.":[54],"Recently,":[55],"artificial":[56],"intelligence":[57],"(AI)":[58],"has":[59],"been":[60],"introduced":[61],"automatically":[63],"analyse":[64],"radiographs,":[66,168],"for":[67,142,161,173,191],"example,":[68],"assess":[70],"alignment.":[72],"These":[73],"tools":[74],"reduce":[75],"measurement":[76],"variability,":[77],"support":[78,119],"high-throughput":[79],"analysis":[80],"of":[81,194,212],"large":[82],"imaging":[83],"datasets,":[84],"help":[86],"identify":[87],"features":[89],"associated":[90,151],"outcomes.":[93,154,196],"A":[94],"focused":[95],"review":[96],"therefore":[98],"needed":[99,240],"clarify":[101],"how":[102,108,115],"biomarkers":[105,150,165,184],"measured,":[107],"they":[109],"relate":[110],"outcomes,":[113],"AI-based":[116,159],"approaches":[117,160],"their":[120],"assessment":[121,177,199],"clinical":[123,223,245],"application":[124],"in":[125,217],"surgical":[126],"planning":[127],"patient":[129],"risk":[130],"stratification.":[131],"In":[132],"this":[133],"review,":[134],"we":[135],"first":[136],"examine":[137],"the":[138],"current":[139],"scoring":[140],"protocols":[141],"evaluating":[143],"potential":[147],"these":[153],"We":[155],"then":[156],"discuss":[157],"existing":[158],"generating":[162],"explore":[170],"future":[171],"directions":[172],"AI-driven":[174,197],"outcome":[180,237],"prediction.":[181],"Knee":[182],"represent":[185],"an":[186],"important":[187],"but":[188],"underexplored":[189],"domain":[190],"improving":[192],"prediction":[193,238],"radiographic":[198],"offers":[200],"promising":[202],"means":[203],"generate":[205],"consistent,":[206],"scalable,":[207],"clinically":[209],"actionable":[210],"measures":[211],"alignment,":[213],"though":[214],"challenges":[215],"remain":[216],"accuracy,":[218],"validation,":[219,229],"multi-view":[220],"integration,":[221],"deployment.":[224],"Improved":[225],"models,":[226],"rigorous":[227],"external":[228],"that":[232],"link":[233],"measurements":[235],"enhance":[242],"reliability":[243],"applicability.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-11-23T00:00:00"}