{"id":"https://openalex.org/W7101242012","doi":null,"title":"Development and charecterization of PLGA-nanoparticles containing carvedilol","display_name":"Development and charecterization of PLGA-nanoparticles containing carvedilol","publication_year":2010,"publication_date":"2010-12-31","ids":{"openalex":"https://openalex.org/W7101242012"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.180.3630","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.180.3630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jpsr.pharmainfo.in/Documents/Volumes/Vol1Issue3/pdf/jpsr01030918.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"N. Jawahar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Jawahar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"D. Nagasamy Venkatesh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Nagasamy Venkatesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R. Sureshkumar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Sureshkumar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"V. Senthil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. Senthil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G. N. K. Ganesh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. N. K. Ganesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"P. Vinoth Sumeet Sood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Vinoth Sumeet Sood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2315,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.51829913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.1006999984383583,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":0.9480000138282776},{"id":"https://openalex.org/keywords/plga-nanoparticles","display_name":"PLGA nanoparticles","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanoprecipitation","display_name":"nanoprecipitation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.8069999814033508},{"id":"https://openalex.org/keywords/antihypertensive-drug-delivery","display_name":"antihypertensive drug delivery","score":0.859000027179718},{"id":"https://openalex.org/keywords/in-vitro-release-kinetics","display_name":"in vitro release kinetics","score":0.7400000095367432},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.8679999709129333},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nanoparticle-size","display_name":"nanoparticle size","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.9024999737739563},{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.8844000101089478},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.767799973487854},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6962000131607056},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6552000045776367},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6237000226974487},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.6208999752998352},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.6029999852180481},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5740000009536743},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48559999465942383},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.4814000129699707},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4650000035762787},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.44839999079704285},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.41589999198913574},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.41029998660087585},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.3716000020503998},{"id":"https://openalex.org/C2777521759","wikidata":"https://www.wikidata.org/wiki/Q61186","display_name":"Microparticle","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.3100000023841858},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.2939999997615814},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.27309998869895935},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.26440000534057617}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.180.3630","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.180.3630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jpsr.pharmainfo.in/Documents/Volumes/Vol1Issue3/pdf/jpsr01030918.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W25951409","https://openalex.org/W32936182","https://openalex.org/W1975133899","https://openalex.org/W1984520012","https://openalex.org/W1987177290","https://openalex.org/W1988297189","https://openalex.org/W2009974403","https://openalex.org/W2035149698","https://openalex.org/W2059862524","https://openalex.org/W2060298851"],"related_works":["https://openalex.org/W6949915760","https://openalex.org/W7098206469","https://openalex.org/W7220486524","https://openalex.org/W2901819765","https://openalex.org/W2241245572","https://openalex.org/W4378515523","https://openalex.org/W3000664800","https://openalex.org/W4412441171","https://openalex.org/W6940035973","https://openalex.org/W2322260612"],"abstract_inverted_index":{"The":[0,72],"objective":[1],"of":[2,10,17,35,64,70],"this":[3],"study":[4],"was":[5,76,91],"to":[6,23,30,120],"prepare":[7],"PLGA":[8,44],"nanoparticles":[9,48,66,90],"Carvedilol":[11,18,38],"that":[12,103],"will":[13],"improve":[14],"the":[15,21,25,32,36,65,89],"bioavailability":[16],"and":[19,29,45,58,111],"sustain":[20],"release":[22,56,87],"reduce":[24],"initial":[26],"hypotensive":[27],"peak":[28],"prolong":[31],"antihypertensive":[33],"effect":[34],"drug.":[37],"encapsulated":[39],"by":[40],"Nanoprecipitation":[41],"method":[42],"using":[43],"Pluronic":[46],"F-68.Prepared":[47],"were":[49,67],"examined":[50],"for":[51],"physicochemical":[52],"characteristics,":[53],"in":[54,68,100,108],"vitro":[55,85],"kinetics":[57],"invivo":[59],"biodistribution":[60,98],"studies.":[61],"Average":[62],"size":[63],"range":[69],"132-234nm.":[71],"drug":[73,82],"encapsulation":[74],"efficiency":[75],"77.6":[77],"%":[78,81,93],"at":[79,94,113],"33":[80],"loading.":[83],"In":[84,96],"cumulative":[86],"from":[88],"72":[92],"24hr.":[95],"vivo":[97],"studies":[99],"rats":[101],"revealed":[102],"these":[104],"particles":[105],"are":[106],"distributed":[107],"heart,":[109],"liver":[110],"kidney":[112],"higher":[114],"concentration":[115],"may":[116],"allow":[117],"their":[118],"delivery":[119],"target":[121],"sites.":[122]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}