{"id":"https://openalex.org/W7101049216","doi":null,"title":"Kinetic Modeling of Short Term Signaling by the Epidermal Growth Factor Receptor","display_name":"Kinetic Modeling of Short Term Signaling by the Epidermal Growth Factor Receptor","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W7101049216"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.106.9366","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.106.9366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.math.wsu.edu/faculty/bkrishna/FilesMath574/Projects/AtefCellSignaling.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Atef Suleiman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Atef Suleiman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6923999786376953,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.22599999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.9850000143051147},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8330000042915344},{"id":"https://openalex.org/keywords/kinetic-modeling","display_name":"kinetic modeling","score":0.9309999942779541},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.4490000009536743},{"id":"https://openalex.org/keywords/receptor-activation","display_name":"receptor activation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/model-reconstruction","display_name":"model reconstruction","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7232999801635742},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.6486999988555908},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6104999780654907},{"id":"https://openalex.org/C165464430","wikidata":"https://www.wikidata.org/wiki/Q1570441","display_name":"Parameterized complexity","level":2,"score":0.5831000208854675},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.515999972820282},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4756999909877777},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43639999628067017},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4081000089645386},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.37779998779296875},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.37400001287460327},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.3560999929904938},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3443000018596649},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.34279999136924744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33980000019073486},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.33500000834465027},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3109000027179718},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3003000020980835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2870999872684479},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C2993627981","wikidata":"https://www.wikidata.org/wiki/Q7456295","display_name":"Set point","level":2,"score":0.2782000005245209},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.26660001277923584}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.106.9366","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.106.9366","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.math.wsu.edu/faculty/bkrishna/FilesMath574/Projects/AtefCellSignaling.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2001620484","https://openalex.org/W7140266177","https://openalex.org/W2075161553","https://openalex.org/W2145899141","https://openalex.org/W1972337004","https://openalex.org/W2165700291","https://openalex.org/W2158682277","https://openalex.org/W2083090087","https://openalex.org/W2138321569","https://openalex.org/W165450908"],"abstract_inverted_index":{"The":[0,33,88],"kinetic":[1,43],"model":[2,34,89],"of":[3,29,36,39,50,61,74,77,85,96,122,129],"short":[4],"term":[5],"signaling":[6,98,124],"by":[7,15],"the":[8,27,75,83,112,117],"Epidermal":[9,78],"Growth":[10,79],"Factor":[11,80],"Receptor":[12],"(EGFR)":[13],"developed":[14],"Kholodenko":[16],"et":[17],"al.":[18],"in":[19],"1999":[20],"was":[21],"reconstructed":[22],"using":[23],"JDesigner":[24],"software":[25],"within":[26],"framework":[28],"System":[30],"Biology":[31],"Workbench.":[32],"consists":[35],"a":[37,68,126],"set":[38],"coupled":[40],"and":[41,58,65,119],"parameterized":[42],"equations":[44],"selected":[45],"based":[46],"on":[47,82],"known":[48],"components":[49],"EGFR":[51,62,97,123],"signal":[52,63],"pathways.":[53],"It":[54],"provides":[55],"an":[56],"integrative":[57],"quantitative":[59,118],"description":[60],"transduction":[64],"agrees":[66],"to":[67,91,110,115],"certain":[69],"extent":[70],"with":[71],"experimental":[72,94],"analysis":[73,95],"effect":[76],"(EGF)":[81],"activation":[84],"downstream":[86],"proteins.":[87],"appears":[90],"deviate":[92],"from":[93],"at":[99],"EGF":[100,130],"concentrations":[101],"below":[102],"saturating":[103],"level.":[104],"Further":[105],"research":[106],"may":[107],"be":[108],"necessary":[109],"improve":[111],"model\u2019s":[113],"ability":[114],"capture":[116],"qualitative":[120],"behavior":[121],"for":[125],"wide":[127],"range":[128],"stimulation.":[131]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-27T00:00:00"}