{"id":"https://openalex.org/W7100747461","doi":null,"title":"Discovery of Allopurinol Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the","display_name":"Discovery of Allopurinol Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W7100747461"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.510.3344","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.510.3344","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mri.jhmi.edu/~rouwerke/rouwerke_data/AmJPhys290pH837.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"First Published Sep","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"First Published Sep","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Eduardo Marb\u00e1n","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eduardo Marb\u00e1n","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Robert G. Weiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert G. Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Anna V. Naumova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna V. Naumova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040675660","display_name":"Ronald Ouwerkerk","orcid":"https://orcid.org/0000-0003-3882-9757","observed_orcids":["https://orcid.org/0000-0003-3882-9757"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald Ouwerkerk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035560205","display_name":"Linda B. Stull","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Stull","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032209826","display_name":"Roger J. Hajjar","orcid":"https://orcid.org/0000-0003-2522-1507","observed_orcids":["https://orcid.org/0000-0003-2522-1507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. J. Hajjar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061025856","display_name":"Jane A. Leopold","orcid":"https://orcid.org/0000-0003-0598-8882","observed_orcids":["https://orcid.org/0000-0003-0598-8882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. A. Leopold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Ventricular Dysfunction","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ventricular Dysfunction","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6045979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":0.09080000221729279,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allopurinol","display_name":"allopurinol","score":0.9829999804496765},{"id":"https://openalex.org/keywords/xanthine-oxidase-inhibitors","display_name":"xanthine oxidase inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/therapeutic-effects","display_name":"therapeutic effects","score":0.7099999785423279},{"id":"https://openalex.org/keywords/history-of-drug-discovery","display_name":"history of drug discovery","score":0.5559999942779541},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.492000013589859},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cardiac-energetics","display_name":"cardiac energetics","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.8284000158309937},{"id":"https://openalex.org/C2780261098","wikidata":"https://www.wikidata.org/wiki/Q412486","display_name":"Allopurinol","level":2,"score":0.8259999752044678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5508999824523926},{"id":"https://openalex.org/C151400659","wikidata":"https://www.wikidata.org/wiki/Q15330855","display_name":"Xanthine dehydrogenase","level":4,"score":0.5453000068664551},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.532800018787384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3817000091075897},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.37049999833106995},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.35030001401901245},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3483999967575073},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C2777820942","wikidata":"https://www.wikidata.org/wiki/Q8042974","display_name":"Xanthine oxidase inhibitor","level":4,"score":0.3118000030517578},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.296999990940094},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C52069626","wikidata":"https://www.wikidata.org/wiki/Q4692","display_name":"The Renaissance","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.25529998540878296}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.510.3344","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.510.3344","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.mri.jhmi.edu/~rouwerke/rouwerke_data/AmJPhys290pH837.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2069249788","https://openalex.org/W2119515450","https://openalex.org/W2027392462","https://openalex.org/W2333013025","https://openalex.org/W2089879470","https://openalex.org/W2948434426","https://openalex.org/W2004153771","https://openalex.org/W162211454","https://openalex.org/W2092460032","https://openalex.org/W2084309268"],"abstract_inverted_index":{"function":[0],"after":[1],"infarction":[2],"in":[3],"failing":[4],"mouse":[5],"hearts":[6],"Xanthine":[7],"oxidase":[8],"inhibitors":[9],"improve":[10],"energetics":[11],"and":[12],"You":[13],"might":[14],"find":[15],"this":[16],"additional":[17],"information":[18],"useful...":[19],"49":[20],"articles,":[21],"27":[22],"of":[23],"which":[24],"you":[25],"can":[26],"access":[27],"free":[28],"at:":[29],"This":[30],"article":[31],"cites":[32]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}