{"id":"https://openalex.org/W7100463092","doi":null,"title":"Reprints and permission:","display_name":"Reprints and permission:","publication_year":2016,"publication_date":"2016-09-02","ids":{"openalex":"https://openalex.org/W7100463092"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.834.438","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.834.438","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://oto.sagepub.com/content/early/2015/06/15/0194599815591156.full.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Standard Of Care","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Standard Of Care","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Eliot Shearer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Eliot Shearer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Richard J. H. Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J. H. Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47924224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.7440000176429749},{"id":"https://openalex.org/keywords/genetic-testing","display_name":"genetic testing","score":0.7409999966621399},{"id":"https://openalex.org/keywords/next-generation-sequencing","display_name":"next-generation sequencing","score":0.7360000014305115},{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.9399999976158142},{"id":"https://openalex.org/keywords/diagnostic-yield","display_name":"diagnostic yield","score":0.5820000171661377},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mode-of-inheritance","display_name":"mode of inheritance","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.7276999950408936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6481999754905701},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.6133999824523926},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.4577000141143799},{"id":"https://openalex.org/C2780554537","wikidata":"https://www.wikidata.org/wiki/Q758881","display_name":"Audiometry","level":3,"score":0.4156999886035919},{"id":"https://openalex.org/C192800701","wikidata":"https://www.wikidata.org/wiki/Q6784807","display_name":"Massive parallel sequencing","level":4,"score":0.40779998898506165},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3700999915599823},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C2910122790","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing problems","level":3,"score":0.29089999198913574},{"id":"https://openalex.org/C2993153387","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic diagnosis","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.2612999975681305}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.834.438","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.834.438","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://oto.sagepub.com/content/early/2015/06/15/0194599815591156.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1952583930","https://openalex.org/W2293733321","https://openalex.org/W2517430650","https://openalex.org/W1968852642","https://openalex.org/W4283590717","https://openalex.org/W2603115912","https://openalex.org/W4396545763","https://openalex.org/W2109414869","https://openalex.org/W2814246515","https://openalex.org/W3084893604"],"abstract_inverted_index":{"Sponsorships":[0],"or":[1],"competing":[2],"interests":[3],"that":[4,59,86,92,237],"may":[5,238],"be":[6,73,239],"relevant":[7],"to":[8,72,175,187,217],"content":[9],"are":[10],"dis-closed":[11],"at":[12],"the":[13,21,110,115,188,211,251],"end":[14],"of":[15,23,98,127,152,192,213,220,254],"this":[16],"article.":[17],"Objective.":[18],"To":[19],"evaluate":[20],"use":[22,151],"new":[24,252],"genetic":[25,30,132,207,247,257],"sequencing":[26],"tech-niques":[27],"for":[28,32,80,134,149,244,256,259],"comprehensive":[29,131,176],"testing":[31,208,236,248,258],"hearing":[33,99,128,135,223,263],"loss.":[34,264],"Data":[35],"Sources.":[36],"Articles":[37],"were":[38,65,70,78,179,200],"identified":[39,54],"from":[40],"PubMed":[41],"and":[42,67,89,106,121,146,164,172,190,195,230,232],"Google":[43],"Scholar":[44],"databases":[45],"using":[46,137],"pertinent":[47],"search":[48,53,61],"terms.":[49],"Review":[50],"Methods.":[51],"Literature":[52],"30":[55],"studies":[56,64,69,77,85,91,102,112],"as":[57],"candi-dates":[58],"met":[60],"criteria.":[62],"Three":[63],"excluded,":[66],"8":[68],"found":[71],"case":[74],"reports.":[75],"Twenty":[76],"included":[79,113,194],"review":[81,116],"analysis,":[82,117],"including":[83,170],"7":[84],"evaluated":[87,93,103],"con-trols":[88],"16":[90],"patients":[94,123,221,260],"with":[95,124,185,222,226,261],"unknown":[96,125],"causes":[97,126],"loss;":[100],"3":[101],"both":[104],"controls":[105],"patients.":[107],"Conclusions.":[108],"In":[109],"20":[111],"in":[114,182],"426":[118],"control":[119],"samples":[120],"603":[122],"loss":[129,136,224],"underwent":[130],"diagnosis":[133],"massively":[138],"parallel":[139],"sequencing.":[140],"Control":[141],"analysis":[142],"showed":[143],"a":[144,214],"sensitivity":[145],"specificity.99%,":[147],"sufficient":[148],"clinical":[150,218],"these":[153,204],"tests.":[154],"The":[155],"overall":[156],"diagnostic":[157],"rate":[158],"was":[159],"41":[160],"%":[161],"(range,":[162],"10%-83%)":[163],"varied":[165],"based":[166],"on":[167,203],"several":[168],"factors,":[169],"inheri-tance":[171],"prescreening":[173],"prior":[174],"testing.":[177],"There":[178],"significant":[180],"differences":[181],"platforms":[183],"available":[184],"regard":[186],"number":[189,198],"type":[191],"genes":[193],"whether":[196],"copy":[197],"variations":[199],"examined.":[201],"Based":[202],"results,":[205],"com-prehensive":[206],"should":[209],"form":[210],"cornerstone":[212],"tiered":[215],"approach":[216],"evaluation":[219],"along":[225],"history,":[227],"physical":[228],"examination,":[229],"audiometry":[231],"can":[233],"determine":[234],"further":[235],"required,":[240],"if":[241],"any.":[242],"Implications":[243],"Practice.":[245],"Comprehensive":[246],"has":[249],"become":[250],"standard":[253],"care":[255],"sensorineural":[262]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-27T00:00:00"}