{"id":"https://openalex.org/W7100461176","doi":null,"title":"Abstract MULTIPLE TRANSLATION FACTOR eIF4G (IFG-1) ISOFORMS ARE REQUIRED FOR THE APOPTOSOME-DEPENDENT ACTIVATION OF GERM CELL APOPTOSIS","display_name":"Abstract MULTIPLE TRANSLATION FACTOR eIF4G (IFG-1) ISOFORMS ARE REQUIRED FOR THE APOPTOSOME-DEPENDENT ACTIVATION OF GERM CELL APOPTOSIS","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W7100461176"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.901.5889","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.901.5889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thescholarship.ecu.edu/bitstream/handle/10342/2926/Contreras_ecu_0600D_10264.pdf%3Bjsessionid%3D81D84560B58ECC5353193E53B61D3D16?sequence%3D1","raw_type":"text"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vince Contreras","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vince Contreras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Director Brett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Director Brett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"D. Keiper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Keiper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.7964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif4g","display_name":"eIF4G","score":0.8370000123977661},{"id":"https://openalex.org/keywords/germ-cell-apoptosis","display_name":"germ cell apoptosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cap-dependent-translation","display_name":"cap-dependent translation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/ires-dependent-translation","display_name":"IRES-mediated translation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apaf-1","display_name":"Apaf-1","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ced-4","display_name":"CED-4","score":0.9779999852180481},{"id":"https://openalex.org/keywords/eif4e","display_name":"eIF4E","score":0.8560000061988831},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8119999766349792},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.4309999942779541},{"id":"https://openalex.org/keywords/caspase-cleavage","display_name":"caspase cleavage","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ribosome-association","display_name":"ribosome association","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C2776054693","wikidata":"https://www.wikidata.org/wiki/Q5323186","display_name":"EIF4G","level":5,"score":0.9564999938011169},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7329000234603882},{"id":"https://openalex.org/C161295673","wikidata":"https://www.wikidata.org/wiki/Q5408696","display_name":"EIF4E","level":5,"score":0.7117000222206116},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6136000156402588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5461999773979187},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.4749000072479248},{"id":"https://openalex.org/C33277056","wikidata":"https://www.wikidata.org/wiki/Q17916089","display_name":"Eukaryotic translation initiation factor 4 gamma","level":5,"score":0.44769999384880066},{"id":"https://openalex.org/C62493599","wikidata":"https://www.wikidata.org/wiki/Q424137","display_name":"Initiation factor","level":5,"score":0.42239999771118164},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.4198000133037567},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.4147999882698059},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4092999994754791},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.3864000141620636},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.37290000915527344},{"id":"https://openalex.org/C97154109","wikidata":"https://www.wikidata.org/wiki/Q906570","display_name":"Eukaryotic initiation factor","level":5,"score":0.3634999990463257},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.3603000044822693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3476000130176544},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C39685955","wikidata":"https://www.wikidata.org/wiki/Q3455905","display_name":"Translational regulation","level":5,"score":0.3059999942779541},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.30230000615119934},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C2780887552","wikidata":"https://www.wikidata.org/wiki/Q7226087","display_name":"Poly(A)-binding protein","level":5,"score":0.2888999879360199},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.2685999870300293}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.901.5889","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.901.5889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thescholarship.ecu.edu/bitstream/handle/10342/2926/Contreras_ecu_0600D_10264.pdf%3Bjsessionid%3D81D84560B58ECC5353193E53B61D3D16?sequence%3D1","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1499405461","https://openalex.org/W2033414229","https://openalex.org/W2086577386","https://openalex.org/W2061623011","https://openalex.org/W2141571283","https://openalex.org/W2320477999","https://openalex.org/W7066756237","https://openalex.org/W30358403","https://openalex.org/W4312093519","https://openalex.org/W2081053429"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1],"a":[2,22,151],"naturally":[3],"occurring":[4],"process":[5],"during":[6],"animal":[7],"development":[8],"required":[9],"for":[10,28],"the":[11,29,37,60,68,82,91,122,131,138],"programmed":[12],"killing":[13],"and":[14,40,80,126,167],"removal":[15],"of":[16,32,52,59,85,93,133,140,163,181],"injured":[17],"cells.":[18,143],"Cellular":[19],"insult":[20],"induces":[21],"switch":[23],"in":[24,103,177],"translation":[25,53,79,104,128,132],"that":[26,34,186],"allows":[27],"rapid":[30],"synthesis":[31,62,84],"proteins":[33],"quickly":[35],"destroy":[36],"unhealthy":[38],"cell":[39],"remove":[41],"it":[42],"from":[43,150],"undamaged":[44],"tissue.":[45],"In":[46],"mammalian":[47],"cells,":[48],"this":[49],"selective":[50],"modulation":[51],"has":[54,97],"been":[55,98],"attributed":[56],"to":[57,76,119,136,156,170],"modifications":[58],"protein":[61,72],"machinery":[63],"by":[64],"apoptotic":[65,107],"caspases.":[66],"Specifically":[67],"initiation":[69],"complex":[70],"scaffold":[71],"eIF4G":[73,146],"becomes":[74],"cleaved":[75],"disrupt":[77],"cap-dependent":[78,125],"induce":[81],"IRES-dependent":[83],"apoptogenic":[86],"mRNAs":[87],"like":[88],"Apaf-1.":[89],"While":[90],"biochemistry":[92],"these":[94],"cleavage":[95],"events":[96],"well":[99],"characterized,":[100],"how":[101,121],"disruptions":[102],"mechanism":[105],"affect":[106],"signaling":[108],"still":[109],"remains":[110],"largely":[111],"unknown.":[112],"The":[113],"nematode":[114],"Caenorhabditis":[115],"elegans":[116,193],"was":[117],"used":[118],"study":[120],"balance":[123],"between":[124],"\u2013independent":[127],"mechanisms":[129],"mediate":[130],"pro-apoptotic":[134],"Apaf-1/CED-4":[135],"alter":[137],"fate":[139],"healthy":[141],"germ":[142],"Two":[144],"major":[145],"(IFG-1)":[147],"isoforms,":[148],"derived":[149],"single":[152],"gene,":[153],"were":[154],"found":[155],"be":[157],"broadly":[158],"expressed":[159],"throughout":[160],"all":[161],"stages":[162],"development.":[164],"IFG-1":[165,188],"p170":[166,189],"p130":[168],"appeared":[169],"both":[171],"associate":[172],"with":[173,191],"ribosomes":[174],"yet":[175],"differed":[176],"their":[178],"N-termini.":[179],"Analysis":[180],"mRNA":[182],"cap":[183],"complexes":[184],"showed":[185],"only":[187],"associates":[190],"C.":[192],"eIF4Es":[194],"(IFEs)":[195]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-27T00:00:00"}
