{"id":"https://openalex.org/W7098098623","doi":null,"title":"Correspondence","display_name":"Correspondence","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W7098098623"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.805.6827","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.805.6827","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8f/52/2757.PMC3068689.pdf","raw_type":"text"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090276752","display_name":"Jiunn C. N. Fong","orcid":"https://orcid.org/0000-0003-3933-7885","observed_orcids":["https://orcid.org/0000-0003-3933-7885"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiunn C. N. Fong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Khalid A. Syed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khalid A. Syed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033454157","display_name":"Karl E. Klose","orcid":"https://orcid.org/0000-0003-2007-1407","observed_orcids":["https://orcid.org/0000-0003-2007-1407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karl E. Klose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021320199","display_name":"Fitnat H. Yildiz","orcid":"https://orcid.org/0000-0002-6384-7167","observed_orcids":["https://orcid.org/0000-0002-6384-7167"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fitnat H. Yildiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Fitnat H. Yildiz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fitnat H. Yildiz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11684","display_name":"Vibrio bacteria research studies","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vibrio-cholerae","display_name":"Vibrio cholerae","score":1.0},{"id":"https://openalex.org/keywords/biofilm-formation","display_name":"biofilm formation","score":0.9769999980926514},{"id":"https://openalex.org/keywords/biofilm-matrix-proteins","display_name":"biofilm matrix proteins","score":0.9129999876022339},{"id":"https://openalex.org/keywords/in-frame-deletion-mutants","display_name":"in-frame deletion mutants","score":0.824999988079071},{"id":"https://openalex.org/keywords/gastrointestinal-colonization","display_name":"intestinal colonization","score":0.9430000185966492},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2778643871","wikidata":"https://www.wikidata.org/wiki/Q160821","display_name":"Vibrio cholerae","level":3,"score":0.9082000255584717},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9077000021934509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7303000092506409},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6726999878883362},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6668000221252441},{"id":"https://openalex.org/C36857842","wikidata":"https://www.wikidata.org/wiki/Q1501261","display_name":"Gene cluster","level":3,"score":0.6316999793052673},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.611299991607666},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5234000086784363},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.38850000500679016},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35749998688697815},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.33340001106262207},{"id":"https://openalex.org/C2776154503","wikidata":"https://www.wikidata.org/wiki/Q753490","display_name":"Vibrio","level":3,"score":0.32249999046325684},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.3027999997138977},{"id":"https://openalex.org/C2776422119","wikidata":"https://www.wikidata.org/wiki/Q910922","display_name":"Vibrionaceae","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C2780722889","wikidata":"https://www.wikidata.org/wiki/Q12090","display_name":"Cholera","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.25769999623298645}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.805.6827","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.805.6827","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8f/52/2757.PMC3068689.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2165017841","https://openalex.org/W2096368653","https://openalex.org/W7168244219","https://openalex.org/W7071079640","https://openalex.org/W1977292147","https://openalex.org/W2924467216","https://openalex.org/W2156319328","https://openalex.org/W4409333274","https://openalex.org/W2755469814","https://openalex.org/W6945907394"],"abstract_inverted_index":{"Biofilm":[0],"formation":[1,97,112,197],"enhances":[2],"the":[3,8,28,34,55,62,74,86,104,123,164,167,170,178,182],"survival":[4],"and":[5,17,61,89,113,136,186,198],"persistence":[6],"of":[7,27,43,85,127,169,181],"facultative":[9],"human":[10],"pathogen":[11],"Vibrio":[12,35],"cholerae":[13,30],"in":[14,52,159,177,200],"natural":[15],"ecosystems":[16],"its":[18],"transmission":[19],"during":[20],"seasonal":[21],"cholera":[22],"outbreaks.":[23],"A":[24],"major":[25],"component":[26],"V.":[29,201],"biofilm":[31,45,80,96,111,196],"matrix":[32,81,92,153],"is":[33,39],"polysaccharide":[36],"(VPS),":[37],"which":[38,101],"essential":[40],"for":[41,110,121],"development":[42],"three-dimensional":[44],"structures.":[46],"The":[47],"vps":[48,87,105,124,147,172,189],"genes":[49,90,102],"are":[50,108],"clustered":[51],"two":[53],"regions,":[54],"vps-I":[56],"cluster":[57,64,77],"(vpsU,":[58],"vpsA\u2013K,":[59],"VC0916\u201327)":[60],"vps-II":[63],"(vpsL\u2013Q,":[65],"VC0934\u2013":[66],"39),":[67],"separated":[68],"by":[69],"an":[70],"intergenic":[71],"region":[72],"containing":[73],"rbm":[75],"gene":[76,106,173,190],"that":[78,143],"encodes":[79],"proteins.":[82],"In-frame":[83],"deletions":[84],"clusters":[88,107,148],"encoding":[91],"proteins":[93],"drastically":[94],"altered":[95],"phenotypes.":[98],"To":[99],"determine":[100],"within":[103],"required":[109],"VPS":[114,135,183,194],"synthesis,":[115],"we":[116],"generated":[117],"in-frame":[118],"deletion":[119],"mutants":[120,129,144],"all":[122],"genes.":[125],"Many":[126],"these":[128],"exhibited":[130,156],"reduced":[131],"capacity":[132],"to":[133,163,193],"produce":[134],"biofilms.":[137],"Infant":[138],"mouse":[139],"colonization":[140,161],"assays":[141],"revealed":[142],"lacking":[145],"either":[146],"or":[149],"rbmA":[150],"(encoding":[151],"secreted":[152],"protein":[154],"RbmA)":[155],"a":[157],"defect":[158],"intestinal":[160],"compared":[162],"wild-type.":[165],"Understanding":[166],"roles":[168],"various":[171],"products":[174,191],"will":[175],"aid":[176],"biochemical":[179],"characterization":[180],"biosynthetic":[184],"pathway":[185],"elucidate":[187],"how":[188],"contribute":[192],"biosynthesis,":[195],"virulence":[199],"cholerae.":[202]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}