{"id":"https://openalex.org/W7098025720","doi":null,"title":"Medical Clinic, Medical Center of the Johannes Gutenberg University,","display_name":"Medical Clinic, Medical Center of the Johannes Gutenberg University,","publication_year":2016,"publication_date":"2016-09-03","ids":{"openalex":"https://openalex.org/W7098025720"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.836.6091","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.836.6091","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://kops.uni-konstanz.de/bitstream/handle/123456789/27192/Schildknecht_271294.pdf%3Bjsessionid%3D6E9AEE09CA5EE860685974CF8BC81D68?sequence%3D2","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060391522","display_name":"Stefan Schildknecht","orcid":"https://orcid.org/0000-0001-9824-4991","observed_orcids":["https://orcid.org/0000-0001-9824-4991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Schildknecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Weber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H. R. Gerding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. R. Gerding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"R. Pape","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Pape","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M. Robotta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Robotta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M. Drescher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Drescher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061715196","display_name":"Andreas Marquardt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Marquardt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A. Daiber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Daiber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"B. Ferger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Ferger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M. Leist","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Leist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mainz Germany","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mainz Germany","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Riss Germany","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riss Germany","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.40818642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.10939999669790268,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.08799999952316284,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxynitrite-scavenging","display_name":"peroxynitrite scavenging","score":0.9589999914169312},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.8650000095367432},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8709999918937683},{"id":"https://openalex.org/keywords/tyrosine-nitration","display_name":"tyrosine nitration","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6240000128746033},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neurite-degeneration","display_name":"neurite degeneration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.8172000050544739},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7350000143051147},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.6276000142097473},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5957000255584717},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5224999785423279},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4672999978065491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.44679999351501465},{"id":"https://openalex.org/C139066938","wikidata":"https://www.wikidata.org/wiki/Q185056","display_name":"Radical","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.42570000886917114},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4097000062465668},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.39149999618530273},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.39079999923706055},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.37929999828338623},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C56783068","wikidata":"https://www.wikidata.org/wiki/Q172867","display_name":"Scavenger","level":3,"score":0.3433000147342682},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.32850000262260437},{"id":"https://openalex.org/C2779385521","wikidata":"https://www.wikidata.org/wiki/Q412383","display_name":"Nitrotyrosine","level":4,"score":0.3107999861240387},{"id":"https://openalex.org/C2776778087","wikidata":"https://www.wikidata.org/wiki/Q427071","display_name":"Hydroxyl radical","level":3,"score":0.29760000109672546},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28459998965263367},{"id":"https://openalex.org/C2777103536","wikidata":"https://www.wikidata.org/wiki/Q7169514","display_name":"Peroxynitrous acid","level":5,"score":0.2827000021934509},{"id":"https://openalex.org/C2777209548","wikidata":"https://www.wikidata.org/wiki/Q414754","display_name":"Apocynin","level":4,"score":0.2822999954223633},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.27390000224113464},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2621000111103058},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.25600001215934753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.836.6091","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.836.6091","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://kops.uni-konstanz.de/bitstream/handle/123456789/27192/Schildknecht_271294.pdf%3Bjsessionid%3D6E9AEE09CA5EE860685974CF8BC81D68?sequence%3D2","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2161279980","https://openalex.org/W2771059099","https://openalex.org/W2013085308","https://openalex.org/W7098369245","https://openalex.org/W7162255526","https://openalex.org/W4386895192","https://openalex.org/W4280495444","https://openalex.org/W2414686680","https://openalex.org/W4306319702","https://openalex.org/W7160210664"],"abstract_inverted_index":{"Abstract:":[0],"NADPH":[1],"oxidases":[2],"(NOX),":[3],"catalyzing":[4],"the":[5,12,60,69,78,112,124,181,188,198,235,245,248],"reduction":[6],"of":[7,62,77,107,126,140,151,183,190,197,216,226,234,247],"molecular":[8],"oxygen":[9],"to":[10,83,170,244],"form":[11],"superoxide":[13],"radical":[14,86],"anion":[15],"(\u2022O2-)":[16],"and":[17,129,145,160,187,240],"hydrogen":[18],"peroxide":[19],"(H2O2),":[20],"are":[21],"involved":[22,122],"in":[23,35,59,111,123,250],"several":[24,251],"pathological":[25],"conditions,":[26],"such":[27,39],"as":[28,40,104,155],"stroke,":[29,65],"diabetes,":[30],"atheroscle":[31],"rosis,":[32],"but":[33,101],"also":[34],"chronic":[36],"neurodegenerative":[37],"diseases":[38],"Parkinson\u2019s":[41,127],"disease,":[42,44],"Alzheimer\u2019s":[43],"or":[45,66,97],"multiple":[46],"sclero":[47],"sis.":[48],"GKT136901":[49,88,141,164,178,201,217],"is":[50,119,228],"a":[51,120,130,173],"novel":[52],"NOX":[53,236],"1/4":[54,237],"inhibitor":[55,238],"with":[56,80,92],"potential":[57],"application":[58],"areas":[61],"diabetic":[63],"nephropathy,":[64],"neurodegeneration.":[67],"In":[68,172,222],"present":[70,193],"study,":[71],"we":[72],"investigated":[73],"additional":[74,230],"pharmacological":[75],"activities":[76],"compound":[79],"re":[81],"spect":[82],"direct":[84],"free":[85],"scavenging.":[87],"did":[89],"not":[90],"interact":[91],"nitric":[93],"oxide":[94],"(\u2022NO),":[95],"\u2022O2-,":[96],"hydroxyl":[98],"radicals":[99],"(\u2022OH),":[100],"it":[102],"acted":[103],"selective":[105,224],"scavenger":[106],"peroxynitrite":[108],"(PON)":[109],"already":[110],"submicromolar":[113],"concentration":[114],"range.":[115],"Alpha":[116],"synuclein":[117],"(ASYN)":[118],"protein":[121],"pathogenesis":[125],"disease":[128,252],"known":[131],"target":[132],"for":[133],"PON":[134,154,195,205,227],"dependent":[135,148],"tyrosine":[136,143,147],"nitration.":[137],"Submicromolar":[138],"concentrations":[139],"prevented":[142,179],"nitration":[144],"di":[146],"dimer":[149],"formation":[150],"ASYN":[152],"by":[153,157],"indicated":[156],"Western":[158],"blot":[159],"mass":[161],"spectrometric":[162],"analysis.":[163],"itself":[165],"was":[166,202,210],"degraded":[167],"when":[168,192],"exposed":[169],"PON.":[171],"human":[174],"neuronal":[175],"cell":[176],"model,":[177],"both":[180],"depletion":[182],"reduced":[184],"intracellular":[185],"glutathione,":[186],"degeneration":[189],"neurites":[191],"during":[194],"treatment":[196],"cells.":[199],"When":[200],"applied":[203],"after":[204],"treatment,":[206],"no":[207],"protective":[208],"effect":[209],"observed,":[211],"thus":[212],"excluding":[213],"an":[214,229],"impact":[215],"on":[218],"cellular":[219],"death/survival":[220],"pathways.":[221],"summary,":[223],"scavenging":[225],"pharmacol":[231],"ogical":[232],"property":[233],"GKT136901,":[239],"this":[241],"may":[242],"add":[243],"efficiency":[246],"drug":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}