{"id":"https://openalex.org/W7098005190","doi":null,"title":"(Experimental Medicine)","display_name":"(Experimental Medicine)","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W7098005190"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.625.2590","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.625.2590","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://circle.ubc.ca/bitstream/handle/2429/11079/ubc_2009_fall_antignano_frann.pdf?sequence=1","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Frann Lillis Antignano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frann Lillis Antignano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Frann Lillis Antignano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frann Lillis Antignano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49898331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02250000089406967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.017899999395012856,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ships","display_name":"ships","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dendritic-cell-differentiation","display_name":"dendritic cell differentiation","score":0.878000020980835},{"id":"https://openalex.org/keywords/dendritic-cell-survival","display_name":"dendritic cell survival","score":0.8429999947547913},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.49399998784065247},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8289999961853027},{"id":"https://openalex.org/keywords/flt3l","display_name":"Flt3L","score":0.9559999704360962},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9649999737739563},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.949999988079071},{"id":"https://openalex.org/keywords/antigen-specific-t-cell-responses","display_name":"antigen-specific T cell responses","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6274999976158142},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.6154999732971191},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5267000198364258},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4950000047683716},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.49140000343322754},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.48840001225471497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46959999203681946},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3939000070095062},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3874000012874603},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.38260000944137573},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.3659000098705292},{"id":"https://openalex.org/C880424","wikidata":"https://www.wikidata.org/wiki/Q416030","display_name":"Colony-stimulating factor","level":4,"score":0.35280001163482666},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C50442881","wikidata":"https://www.wikidata.org/wiki/Q426626","display_name":"Macrophage colony-stimulating factor","level":4,"score":0.33399999141693115},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3118000030517578},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C2779958370","wikidata":"https://www.wikidata.org/wiki/Q5711176","display_name":"Hematopoietic growth factor","level":4,"score":0.30709999799728394},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29280000925064087},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2913999855518341},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.28790000081062317},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2793000042438507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2791999876499176},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.2775000035762787},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.257999986410141},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.625.2590","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.625.2590","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://circle.ubc.ca/bitstream/handle/2429/11079/ubc_2009_fall_antignano_frann.pdf?sequence=1","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2171772001","https://openalex.org/W2143720746","https://openalex.org/W1967945803","https://openalex.org/W2895689046","https://openalex.org/W178627171","https://openalex.org/W2028112607","https://openalex.org/W2157429934","https://openalex.org/W2468798200","https://openalex.org/W2151313755","https://openalex.org/W2051141212"],"abstract_inverted_index":{"ii":[0],"SHIP":[1,38,51],"(SH2-containing":[2],"inositol":[3],"5\u2032-phosphatase)":[4],"is":[5,150],"a":[6,35,112],"hematopoietic":[7],"restricted":[8],"enzyme":[9],"responsible":[10],"for":[11,37],"the":[12,15,40,83],"hydrolysis":[13],"of":[14,44,58,93],"phosphatidylinositol":[16],"3-kinase-generated":[17],"second":[18],"messenger":[19],"PI-3,4,5-P3":[20],"to":[21,107,125],"PI-3,4-P2":[22],"and,":[23],"thereby,":[24],"negatively":[25],"regulates":[26],"cell":[27,134,141],"survival,":[28],"proliferation":[29],"and":[30,42,56,119,145],"differentiation.":[31],"Herein,":[32],"we":[33],"demonstrate":[34],"role":[36,149],"in":[39,53,84,123,143,146],"differentiation":[41],"function":[43],"dendritic":[45],"cells":[46,110],"(DCs).":[47],"We":[48,96],"found":[49],"that":[50,87,99],"restrains":[52],"vitro":[54,144],"generation":[55],"survival":[57],"bone":[59],"marrow":[60],"derived":[61],"DCs":[62,102],"cultured":[63],"with":[64,82,115,138],"granulocyte":[65],"macrophage":[66],"colony":[67],"stimulating":[68],"factor":[69],"(GM-CSF)":[70],"or":[71],"fms-like":[72],"tyrosine":[73],"kinase":[74],"3":[75],"ligand":[76],"(Flt3L).":[77],"These":[78],"results":[79],"are":[80],"consistent":[81],"vivo":[85],"finding":[86],"SHIP-deficient":[88],"mice":[89],"have":[90,104],"increased":[91],"numbers":[92],"splenic":[94],"DCs.":[95],"provide":[97],"evidence":[98],"Ship-/-":[100],"GM-CSF-derived":[101],"(GM-DCs)":[103],"impaired":[105],"ability":[106],"activate":[108],"T":[109,133],"\u2013":[111],"defect":[113],"associated":[114,137],"deficient":[116],"DC":[117],"maturation":[118],"interleukin-12":[120],"(IL-12)":[121],"production":[122],"response":[124],"Toll-like":[126],"receptor":[127],"(TLR)":[128],"agonists.":[129],"Reduced":[130],"antigen":[131],"(Ag)-specific":[132],"activation":[135],"was":[136],"defective":[139],"TH1":[140],"induction":[142],"vivo.":[147],"SHIP\u2019s":[148],"more":[151]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-27T00:00:00"}
