{"id":"https://openalex.org/W7097778489","doi":null,"title":"The role of the Parkinson\u2019s disease gene PARK9 in essential cellular pathways and the manganese homeostasis network","display_name":"The role of the Parkinson\u2019s disease gene PARK9 in essential cellular pathways and the manganese homeostasis network","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W7097778489"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.3401","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.3401","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8f/fd/pone.0034178.PMC3311584.pdf","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145900120","display_name":"Ra Chesi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ra Chesi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144545190","display_name":"Austin Kilaru","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Austin Kilaru","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052083635","display_name":"Xiaodong Fang","orcid":"https://orcid.org/0000-0001-7061-3337","observed_orcids":["https://orcid.org/0000-0001-7061-3337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaodong Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046356609","display_name":"Antony A. Cooper","orcid":"https://orcid.org/0000-0002-6027-2353","observed_orcids":["https://orcid.org/0000-0002-6027-2353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antony A. Cooper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087989608","display_name":"Aaron D. Gitler","orcid":"https://orcid.org/0000-0001-8603-1526","observed_orcids":["https://orcid.org/0000-0001-8603-1526"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aaron D. Gitler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54409296,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8955000042915344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/park9","display_name":"PARK9","score":0.7450000047683716},{"id":"https://openalex.org/keywords/atp13a2","display_name":"ATP13A2","score":0.9129999876022339},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7329999804496765},{"id":"https://openalex.org/keywords/manganese-homeostasis","display_name":"manganese homeostasis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/manganese-toxicity","display_name":"manganese toxicity","score":0.9100000262260437},{"id":"https://openalex.org/keywords/p-type-atpase","display_name":"P-type ATPase","score":0.796999990940094},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.7089999914169312},{"id":"https://openalex.org/keywords/genetic-interactions","display_name":"genetic interactions","score":0.7730000019073486},{"id":"https://openalex.org/keywords/genome-wide-deletion-screen","display_name":"genome-wide deletion screen","score":0.6399999856948853},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.41100001335144043},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.4880000054836273},{"id":"https://openalex.org/keywords/cell-trafficking","display_name":"cell trafficking","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7408999800682068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6861000061035156},{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.6710000038146973},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6510999798774719},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5426999926567078},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5314000248908997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5264000296592712},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4848000109195709},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4650000035762787},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.420199990272522},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4072999954223633},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3880999982357025},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3488999903202057},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3098999857902527},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30160000920295715},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C207177822","wikidata":"https://www.wikidata.org/wiki/Q5050812","display_name":"Genetic screen","level":4,"score":0.2955999970436096},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2800000011920929},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.2761000096797943},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.26109999418258667}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.3401","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.3401","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8f/fd/pone.0034178.PMC3311584.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2004914033","https://openalex.org/W31525717","https://openalex.org/W7216717924","https://openalex.org/W7001915934","https://openalex.org/W196123432","https://openalex.org/W7099240369","https://openalex.org/W45444315","https://openalex.org/W7217281546","https://openalex.org/W1987820478","https://openalex.org/W7097027815"],"abstract_inverted_index":{"YPK9":[0],"(Yeast":[1],"PARK9;":[2],"also":[3],"known":[4],"as":[5],"YOR291W)":[6],"is":[7,26,93,107],"a":[8,17,50,68,87,168,221,228],"non-essential":[9,171],"yeast":[10,117,161],"gene":[11,172],"predicted":[12],"by":[13,129],"sequence":[14],"to":[15,40,81,90,105,163,165,182],"encode":[16],"transmembrane":[18],"P-type":[19],"transport":[20],"ATPase.":[21],"However,":[22],"its":[23],"substrate":[24],"specificity":[25],"unknown.":[27],"Mutations":[28],"in":[29,63,72,75,116,150,180,191,203,232],"the":[30,100,121,127,154,196,199,204,216],"human":[31],"homolog":[32],"of":[33,43,84,124,158,170,198,206,219,223],"YPK9,":[34],"ATP13A2/":[35],"PARK9,":[36],"have":[37],"been":[38],"linked":[39],"genetic":[41,52],"forms":[42],"early":[44],"onset":[45],"parkinsonism.":[46],"We":[47,194],"previously":[48],"described":[49],"strong":[51],"interaction":[53],"between":[54],"Ypk9":[55,71,125,143,159,213,231],"and":[56,67,92,126,153,210],"another":[57],"Parkinson\u2019s":[58],"disease":[59],"(PD)":[60],"protein":[61],"a-synuclein":[62],"multiple":[64,113],"model":[65],"systems,":[66],"role":[69,229],"for":[70,99,176,230],"manganese":[73,85,103,135,184,192,207,217,233],"detoxification":[74],"yeast.":[76],"In":[77,137],"humans,":[78],"environmental":[79,96],"exposure":[80,164],"toxic":[82],"levels":[83],"causes":[86],"syndrome":[88],"similar":[89],"PD":[91],"thus":[94],"an":[95],"risk":[97],"factor":[98],"disease.":[101],"How":[102],"contributes":[104],"neurodegeneration":[106],"poorly":[108],"understood.":[109],"Here":[110],"we":[111,140,174],"describe":[112],"genome-wide":[114],"screens":[115],"aimed":[118],"at":[119],"defining":[120],"cellular":[122,151],"function":[123],"mechanisms":[128],"which":[130],"it":[131],"protects":[132],"cells":[133,162],"from":[134],"toxicity.":[136],"physiological":[138],"conditions,":[139],"found":[141,211],"that":[142,212],"genetically":[144],"interacts":[145],"with":[146],"essential":[147],"genes":[148,178],"involved":[149,179,190],"trafficking":[152],"cell":[155],"cycle.":[156],"Deletion":[157],"sensitizes":[160],"excessmanganese.":[166],"Using":[167],"library":[169],"deletions,":[173],"screened":[175],"additional":[177],"tolerance":[181,218],"excess":[183],"exposure,":[185],"discovering":[186],"several":[187],"novel":[188],"pathways":[189],"homeostasis.":[193],"defined":[195],"dependence":[197],"deletion":[200,214],"strain":[201],"phenotypes":[202],"presence":[205],"on":[208],"Ypk9,":[209],"modifies":[215],"only":[220],"subset":[222],"strains.":[224],"These":[225],"results":[226],"confirm":[227]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2026-08-07T00:00:00"}
