{"id":"https://openalex.org/W7097761138","doi":null,"title":"Summary","display_name":"Summary","publication_year":2013,"publication_date":"2013-08-08","ids":{"openalex":"https://openalex.org/W7097761138"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.6301","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.6301","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://zebrafish.ust.hk/25 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000328709","display_name":"Zilong Wen","orcid":"https://orcid.org/0000-0002-4260-7682","observed_orcids":["https://orcid.org/0000-0002-4260-7682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zilong Wen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Zhong Zhong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhong Zhong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109092455","display_name":"James E. Darnell Jr.","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James E. Darnell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45363375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":1.0},{"id":"https://openalex.org/keywords/serine-phosphorylation","display_name":"serine phosphorylation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.7850000262260437},{"id":"https://openalex.org/keywords/growth-factor-signaling","display_name":"growth factor signaling","score":0.968999981880188},{"id":"https://openalex.org/keywords/serine-kinase","display_name":"serine kinase","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.6460000276565552},{"id":"https://openalex.org/keywords/gene-activation","display_name":"gene activation","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.840499997138977},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.7027000188827515},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.6872000098228455},{"id":"https://openalex.org/C104551158","wikidata":"https://www.wikidata.org/wiki/Q7187581","display_name":"Phosphorylation cascade","level":5,"score":0.5304999947547913},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4993000030517578},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4668000042438507},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4219000041484833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39629998803138733},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.37040001153945923},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32760000228881836},{"id":"https://openalex.org/C2909867262","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Protein-Tyrosine Kinases","level":4,"score":0.30799999833106995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30230000615119934},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29429998993873596},{"id":"https://openalex.org/C2780307904","wikidata":"https://www.wikidata.org/wiki/Q2701649","display_name":"Phosphoserine","level":4,"score":0.2842000126838684},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.2685999870300293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2685000002384186},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.26669999957084656},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.2619999945163727},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25850000977516174},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25459998846054077}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.6301","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.6301","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://zebrafish.ust.hk/25 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phopshorylation.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2030865745","https://openalex.org/W2068724210","https://openalex.org/W1994479081","https://openalex.org/W2140786721","https://openalex.org/W2314865317","https://openalex.org/W1984486504","https://openalex.org/W2131444119","https://openalex.org/W1993451588","https://openalex.org/W2025188362","https://openalex.org/W1879729745"],"abstract_inverted_index":{"Statl":[0,60,70],"and":[1,18,49,61,71],"Stat3":[2],"are":[3,52],"latent":[4],"transcriptional":[5,45],"factors":[6,51],"activated":[7],"initially":[8],"through":[9],"phosphorylation":[10,30,58,77],"on":[11,31,86],"single":[12,33],"tyrosine":[13,76],"residues":[14],"induced":[15],"by":[16,69],"cytokine":[17],"growth":[19,50],"factor":[20],"occupation":[21],"of":[22,54,59,90],"cell":[23],"surface":[24],"receptors.":[25],"Here":[26],"we":[27],"show":[28,65],"that":[29,66],"a":[32],"serine":[34,57,93],"(residue":[35],"727)":[36],"in":[37],"each":[38],"protein":[39],"is":[40],"also":[41,81],"required":[42],"for":[43,83],"maximal":[44,84],"activity.":[46],"Both":[47],"cytokines":[48],"capable":[53],"inducing":[55],"the":[56,91],"Stat3.":[62],"These":[63],"experiments":[64],"gene":[67],"activation":[68,85],"Stat3,":[72],"which":[73],"obligatorily":[74],"require":[75],"to":[78],"become":[79],"active,":[80],"depends":[82],"one":[87],"or":[88],"more":[89],"many":[92],"kinases.":[94]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}