{"id":"https://openalex.org/W7097645852","doi":null,"title":", Wook-bin Lee","display_name":", Wook-bin Lee","publication_year":2014,"publication_date":"2014-12-16","ids":{"openalex":"https://openalex.org/W7097645852"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.483.2859","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.483.2859","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://genome.yonsei.ac.kr/files/1195264427.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091731940","display_name":"Lark Kyun Kim","orcid":"https://orcid.org/0000-0001-5983-4470","observed_orcids":["https://orcid.org/0000-0001-5983-4470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lark Kyun Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Un Yung Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Un Yung Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004678522","display_name":"Jung Seon Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jung Seon Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jihyun Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jihyun Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041926081","display_name":"Kyoungsuk Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyoungsuk Jeong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jaewon Shim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaewon Shim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Young-joon Kim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Young-joon Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.41804889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.4733999967575073,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.4733999967575073,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11403","display_name":"Invertebrate Immune Response Mechanisms","score":0.46630001068115234,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.9169999957084656},{"id":"https://openalex.org/keywords/stat92e","display_name":"Stat92E","score":0.8309999704360962},{"id":"https://openalex.org/keywords/relish","display_name":"Relish","score":0.6909999847412109},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8370000123977661},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.703000009059906},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7940000295639038},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.972000002861023},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.35100001096725464},{"id":"https://openalex.org/keywords/bacterial-infection","display_name":"bacterial infection","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7799000144004822},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7538999915122986},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7527999877929688},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.743399977684021},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.597000002861023},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.5964999794960022},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5033000111579895},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4758000075817108},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.436599999666214},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.40070000290870667},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.39739999175071716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3971000015735626},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3781000077724457},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.37470000982284546},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3528999984264374},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.3294999897480011},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3188000023365021},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.30660000443458557},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.30660000443458557},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2906000018119812},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.27790001034736633},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2741999924182892},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.26919999718666077},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.2685000002384186},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26089999079704285}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.483.2859","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.483.2859","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://genome.yonsei.ac.kr/files/1195264427.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098367886","https://openalex.org/W2012532513","https://openalex.org/W1994557554","https://openalex.org/W7099362937","https://openalex.org/W7074154348","https://openalex.org/W2016401677","https://openalex.org/W2088249321","https://openalex.org/W1993957633","https://openalex.org/W7097129189","https://openalex.org/W4387377335"],"abstract_inverted_index":{"The":[0,19,124],"activation":[1,87,200],"of":[2,11,32,63,98,135,157,165,173,196,201,214,223],"several":[3],"transcription":[4,20],"factors":[5,21],"is":[6,208,229],"required":[7,230],"for":[8,83,210,231],"the":[9,15,30,41,64,79,89,96,119,133,171,188,211,215],"elimination":[10],"infectious":[12],"pathogens":[13],"via":[14],"innate":[16,37,90],"immune":[17,33,38,45,91,106,137,234],"response.":[18],"NF-jB,":[22],"AP-1,":[23],"and":[24,58,61,75,100,127,146,169,225,236],"STAT":[25,76,226],"play":[26,109],"major":[27,80],"roles":[28],"in":[29,93,163],"synthesis":[31],"effector":[34,138],"molecules":[35],"during":[36,88],"responses.":[39],"However,":[40],"fact":[42],"that":[43,73,194,219],"these":[44],"responses":[46,235],"can":[47],"have":[48],"cytotoxic":[49],"effects":[50],"requires":[51],"their":[52],"tight":[53],"regulation":[54],"to":[55,104,142,151,238],"achieve":[56],"restricted":[57],"transient":[59],"activation,":[60],"mis-regulation":[62,195],"damping":[65,84],"process":[66],"has":[67],"pathological":[68],"consequences.":[69],"Here":[70],"we":[71],"show":[72],"AP-1":[74,224],"are":[77,184],"themselves":[78],"inhibitors":[81],"responsible":[82,209],"NF-jB\u2013mediated":[85],"transcriptional":[86],"response":[92],"Drosophila.":[94],"As":[95],"levels":[97],"dAP-1":[99],"Stat92E":[101],"increase":[102],"due":[103],"continuous":[105],"signaling,":[107],"they":[108,147],"a":[110,115],"repressive":[111],"role":[112],"by":[113,140,155,186],"forming":[114],"repressosome":[116],"complex":[117],"with":[118],"Drosophila":[120],"HMG":[121],"protein,":[122],"Dsp1.":[123],"dAP-1\u2013,":[125],"Stat92E-,":[126],"Dsp1-containing":[128],"complexes":[129],"replace":[130],"Relish":[131,166,189],"at":[132],"promoters":[134],"diverse":[136],"genes":[139,168],"binding":[141],"evolutionarily":[143,240],"conserved":[144],"cis-elements,":[145],"recruit":[148],"histone":[149],"deacetylase":[150],"inhibit":[152],"transcription.":[153],"Reduction":[154],"mutation":[156],"dAP-1,":[158,202],"Stat92E,":[159,203],"or":[160,204],"Dsp1":[161,205],"results":[162],"hyperactivation":[164],"target":[167,206],"reduces":[170],"viability":[172],"bacterially":[174],"infected":[175],"flies":[176],"despite":[177],"more":[178],"efficient":[179],"pathogen":[180],"clearance.":[181],"These":[182],"defects":[183],"rescued":[185],"reducing":[187],"copy":[190],"number,":[191],"thus":[192],"confirming":[193],"Relish,":[197],"not":[198],"inadequate":[199],"genes,":[207],"reduced":[212],"survival":[213],"mutants.":[216],"We":[217],"conclude":[218],"an":[220],"inhibitory":[221],"effect":[222],"on":[227],"NF-jB":[228],"properly":[232],"balanced":[233],"appears":[237],"be":[239],"conserved.":[241]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}