{"id":"https://openalex.org/W7097638580","doi":null,"title":"REVIEW Update on the use of fi brates: focus on bezafi brate","display_name":"REVIEW Update on the use of fi brates: focus on bezafi brate","publication_year":2013,"publication_date":"2013-03-29","ids":{"openalex":"https://openalex.org/W7097638580"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.4888","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.4888","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/d5/Vasc_Health_Risk_Manag_2008_Feb_4(1)_131-141.tar.gz","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ilan Goldenberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilan Goldenberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012270561","display_name":"Michal Benderly","orcid":"https://orcid.org/0000-0001-6174-6322","observed_orcids":["https://orcid.org/0000-0001-6174-6322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michal Benderly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Uri Goldbourt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uri Goldbourt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56265097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bezafibrate","display_name":"bezafibrate","score":0.949999988079071},{"id":"https://openalex.org/keywords/fibrates","display_name":"fibrates","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/apolipoprotein-synthesis","display_name":"apolipoprotein synthesis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/lipoprotein-metabolism","display_name":"lipoprotein metabolism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5230000019073486},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.6269999742507935},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.7409999966621399},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C2776362216","wikidata":"https://www.wikidata.org/wiki/Q577387","display_name":"Bezafibrate","level":2,"score":0.9532999992370605},{"id":"https://openalex.org/C2776933373","wikidata":"https://www.wikidata.org/wiki/Q424744","display_name":"Fibrate","level":3,"score":0.701200008392334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6741999983787537},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.6654000282287598},{"id":"https://openalex.org/C2778110834","wikidata":"https://www.wikidata.org/wiki/Q419724","display_name":"Fenofibrate","level":2,"score":0.5698000192642212},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.49320000410079956},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37940001487731934},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.35409998893737793},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3328999876976013},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33000001311302185},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.3133000135421753},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2948000133037567},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C2991848491","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disease","level":2,"score":0.26840001344680786},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.26669999957084656},{"id":"https://openalex.org/C2993857929","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Primary prevention","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26249998807907104},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25940001010894775},{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.25440001487731934}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.4888","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.4888","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/d5/Vasc_Health_Risk_Manag_2008_Feb_4(1)_131-141.tar.gz","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2080575646","https://openalex.org/W2318286563","https://openalex.org/W2059634850","https://openalex.org/W2344525149","https://openalex.org/W2000197810","https://openalex.org/W2019632139","https://openalex.org/W1974212760","https://openalex.org/W2061245912","https://openalex.org/W2074184658","https://openalex.org/W2090101356"],"abstract_inverted_index":{"Abstract:":[0],"Low-density":[1],"lipoprotein-cholesterol":[2,38],"(LDL-C)":[3],"is":[4,32],"a":[5,70,90],"well":[6,105,157],"established":[7],"coronary":[8],"heart":[9],"disease":[10],"(CHD)":[11],"risk":[12,20,27,48],"factor.":[13],"However,":[14],"the":[15,94,108,128,136,151,165,182],"ability":[16],"of":[17,51,72,96,101,110,130,148,154,167,170,181,195],"this":[18,168],"metabolic":[19,190],"factor":[21,49],"alone":[22],"to":[23,43,75],"identify":[24],"individuals":[25],"at":[26],"for":[28,64],"future":[29],"CHD":[30],"events":[31],"limited.":[33],"The":[34],"raised":[35,137],"triglycerides-low":[36,138],"high-density":[37],"(HDL-C)":[39],"dyslipidemia":[40],"was":[41],"shown":[42],"be":[44],"an":[45],"important":[46,189],"cardiovascular":[47,193],"independently":[50],"LDL-C":[52],"levels.":[53,83],"Fibric":[54],"acid":[55],"derivatives":[56],"(fibrates)":[57],"have":[58,89],"been":[59],"used":[60],"in":[61,114,133],"clinical":[62,125,162],"practice":[63],"more":[65],"than":[66],"2":[67],"decades":[68],"as":[69,104,106,156,158],"class":[71],"agents":[73],"known":[74],"decrease":[76],"triglyceride":[77],"levels":[78],"while":[79],"substantially":[80],"increasing":[81],"HDL-C":[82,139],"Through":[84],"peroxisome":[85],"proliferator-activated":[86],"\u03b1-receptors,":[87],"fibrates":[88],"significant":[91],"impact":[92],"on":[93,107,164],"synthesis":[95],"several":[97,111,188],"apolipoproteins":[98],"and":[99,116,122,150,191],"enzymes":[100],"lipoprotein":[102],"metabolism":[103],"expression":[109],"genes":[112],"involved":[113],"fibrinolysis":[115],"inflammation.":[117],"Data":[118],"from":[119,160,178],"recent":[120,176],"primary":[121],"secondary":[123],"prevention":[124],"trials":[126,163],"demonstrate":[127],"efficacy":[129,166],"fibrate":[131],"therapy":[132],"patients":[134],"with":[135],"dyslipidemia.":[140],"This":[141],"review":[142],"summarizes":[143],"current":[144],"data":[145,177],"regarding":[146],"mechanism":[147],"action":[149],"metbolic":[152],"effects":[153,194],"fibrates,":[155],"results":[159],"major":[161],"mode":[169],"lipid":[171],"lowering":[172],"therapy.":[173],"In":[174],"addition,":[175],"subgroup":[179],"analyses":[180],"Bezafibrate":[183],"Infarction":[184],"Prevention":[185],"trial,":[186],"demonstrating":[187],"long-term":[192],"bezafibrate":[196],"therapy,":[197],"are":[198],"detailed.":[199]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-27T00:00:00"}
