{"id":"https://openalex.org/W7097474398","doi":null,"title":"OPEN LEADING ARTICLE","display_name":"OPEN LEADING ARTICLE","publication_year":2016,"publication_date":"2016-10-21","ids":{"openalex":"https://openalex.org/W7097474398"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1015.1359","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1015.1359","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3918868%26blobtype%3Dpdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50287411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":1.0},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9520000219345093},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.9480000138282776},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tet2","display_name":"TET2","score":0.8399999737739563},{"id":"https://openalex.org/keywords/sf3b1","display_name":"SF3B1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/asxl1","display_name":"ASXL1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/srsf2","display_name":"SRSF2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":1.0},{"id":"https://openalex.org/keywords/runx1","display_name":"RUNX1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prpf8","display_name":"PRPF8","score":0.9039999842643738},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.7149999737739563},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.621399998664856},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.510200023651123},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4846999943256378},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44029998779296875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4253999888896942},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.40639999508857727},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3910999894142151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3684000074863434},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36399999260902405},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3580999970436096},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.33869999647140503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33059999346733093},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3278000056743622},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.2782999873161316},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2736000120639801},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C23085057","wikidata":"https://www.wikidata.org/wiki/Q5532877","display_name":"Genetic analysis","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1015.1359","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1015.1359","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3918868%26blobtype%3Dpdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2026134786","https://openalex.org/W2921606836","https://openalex.org/W2591545264","https://openalex.org/W3127892484","https://openalex.org/W4200562109","https://openalex.org/W4400287077","https://openalex.org/W2735396245","https://openalex.org/W4223631613","https://openalex.org/W2552070582","https://openalex.org/W2767499299"],"abstract_inverted_index":{"High-throughput":[0],"DNA":[1],"sequencing":[2,46],"significantly":[3,70,111],"contributed":[4],"to":[5],"diagnosis":[6],"and":[7,19,47,78,151,190,201],"prognostication":[8,202],"in":[9,25,40,98,178,203],"patients":[10,30,54,133],"with":[11,31,72,88,123,144],"myelodysplastic":[12],"syndromes":[13],"(MDS).":[14],"We":[15],"determined":[16],"the":[17,179],"biological":[18],"prognostic":[20,129],"significance":[21],"of":[22,82,119,147,193],"genetic":[23,189],"aberrations":[24],"MDS.":[26],"In":[27,51],"total,":[28,52],"944":[29],"various":[32],"MDS":[33,204],"subtypes":[34],"were":[35,69,86,176],"screened":[36],"for":[37,199],"known/putative":[38],"mutations/deletions":[39],"104":[41],"genes":[42,68,105,109,121,166,196],"using":[43],"targeted":[44],"deep":[45],"array-based":[48],"genomic":[49],"hybridization.":[50],"845/944":[53],"(89.5%)":[55],"harbored":[56],"at":[57],"least":[58],"one":[59],"mutation":[60],"(median,":[61],"3":[62],"per":[63],"patient;":[64],"range,":[65],"0\u201312).":[66],"Forty-seven":[67],"mutated":[71,80],"TET2,":[73],"SF3B1,":[74],"ASXL1,":[75],"SRSF2,":[76],"DNMT3A,":[77],"RUNX1":[79],"in410%":[81],"cases.":[83],"Many":[84],"mutations":[85],"associated":[87],"higher":[89],"risk":[90,136,171],"groups":[91,137,172],"and/or":[92],"blast":[93],"elevation.":[94],"Survival":[95],"was":[96,161],"investigated":[97],"875":[99],"patients.":[100,205],"By":[101],"univariate":[102],"analysis,":[103],"25/48":[104],"(resulting":[106],"from":[107],"47":[108],"tested":[110],"plus":[112],"PRPF8)":[113],"affected":[114],"survival":[115,146],"(Po0.05).":[116],"The":[117],"status":[118],"14":[120,165],"combined":[122],"conventional":[124],"factors":[125],"revealed":[126],"a":[127,156],"novel":[128],"model":[130,158],"(\u2018Model-1\u2019)":[131],"separating":[132],"into":[134],"four":[135,169],"(\u2018low\u2019,":[138],"\u2018intermediate\u2019,":[139],"\u2018high\u2019,":[140],"\u2018very":[141],"high":[142],"risk\u2019)":[143],"3-year":[145],"95.2,":[148],"69.3,":[149],"32.8,":[150],"5.3":[152],"%":[153],"(Po0.001).":[154,173],"Subsequently,":[155],"\u2018gene-only":[157],"\u2019":[159],"(\u2018Model-2\u2019)":[160],"constructed":[162],"based":[163],"on":[164],"also":[167],"yielding":[168],"significant":[170],"Both":[174],"models":[175],"reproducible":[177],"validation":[180],"cohort":[181],"(n":[182],"175":[183],"patients;":[184],"Po0.001":[185],"each).":[186],"Thus,":[187],"large-scale":[188],"molecular":[191],"profiling":[192],"multiple":[194],"target":[195],"is":[197],"invaluable":[198],"subclassification":[200]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-10-27T00:00:00"}