{"id":"https://openalex.org/W7097184207","doi":null,"title":"Summary","display_name":"Summary","publication_year":2016,"publication_date":"2016-08-24","ids":{"openalex":"https://openalex.org/W7097184207"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.176","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/06/ad/acel0013-0254.PMC4331780.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Lydie Combaret","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lydie Combaret","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Daniel Taill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Taill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042111402","display_name":"Didier Attaix","orcid":"https://orcid.org/0000-0002-0429-9957","observed_orcids":["https://orcid.org/0000-0002-0429-9957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Didier Attaix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087690382","display_name":"Claire Lethias","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire Lethias","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kijoon Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kijoon Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kheng Lim Goh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kheng Lim Goh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Saint Gene\u0300s Champanelle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saint Gene\u0300s Champanelle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39212387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/muscle-aging","display_name":"muscle aging","score":0.6470000147819519},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.7599999904632568},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/myonuclei","display_name":"myonuclei","score":0.8090000152587891},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.7570000290870667},{"id":"https://openalex.org/keywords/dystrophin","display_name":"dystrophin","score":0.6949999928474426},{"id":"https://openalex.org/keywords/pax7","display_name":"Pax7","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tunel-assay","display_name":"TUNEL","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.8536999821662903},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7652999758720398},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7534000277519226},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.534600019454956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43880000710487366},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4180999994277954},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4059000015258789},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.36230000853538513},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C2910232053","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"In Situ Nick-End Labeling","level":4,"score":0.33079999685287476},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31459999084472656},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2678999900817871}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.176","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.176","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/06/ad/acel0013-0254.PMC4331780.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107698649","https://openalex.org/W2528219309","https://openalex.org/W4238853963","https://openalex.org/W1898153","https://openalex.org/W2088184393","https://openalex.org/W2107596619","https://openalex.org/W2052252703","https://openalex.org/W2048509129","https://openalex.org/W2045709794","https://openalex.org/W1888940543"],"abstract_inverted_index":{"The":[0],"age-related":[1],"loss":[2],"of":[3,14,44,61],"skeletal":[4],"muscle":[5,51],"mass":[6],"and":[7,63,102],"function":[8],"(sarco-penia)":[9],"is":[10,30],"a":[11,74],"consistent":[12],"hallmark":[13],"ageing.":[15,80],"Apoptosis":[16],"plays":[17],"an":[18],"important":[19],"role":[20],"inmuscleatrophy,and":[21],"the":[22],"intentof":[23],"this":[24],"studywas":[25],"to":[26,32,95,115,126],"specify":[27],"whether":[28],"apoptosis":[29,78,97,108],"restricted":[31,114],"myofibre":[33,55],"nuclei":[34,122],"(myonu-clei)":[35],"or":[36,41,90],"occurs":[37],"in":[38,48,77,98,120],"satellite":[39,100],"cells":[40,43,101],"stromal":[42,103,116,127],"extracellularmatrix":[45],"(ECM).":[46],"Sarcopenia":[47],"mouse":[49],"gastrocnemius":[50],"was":[52,93,109,123],"character-ized":[53],"by":[54],"atrophy,":[56],"oxidative":[57],"type":[58],"grouping,":[59],"delocalization":[60],"myonuclei":[62],"ECM":[64],"fibrosis.":[65],"Terminal":[66],"deoxynucleotidyl":[67],"trans-ferase-mediated":[68],"dUTP":[69],"nick":[70],"end-labelling":[71],"(TUNEL)":[72],"indicated":[73],"sharp":[75],"rise":[76,119],"during":[79],"TUNEL":[81],"coupledwith":[82],"immunostain-ing":[83],"for":[84],"dystrophin,":[85],"paired":[86],"box":[87],"protein-7":[88],"(Pax7)":[89],"laminin-2a,":[91],"respectively,":[92],"used":[94],"identify":[96],"myonuclei,":[99],"cells.":[104,128],"In":[105],"adult":[106],"muscle,":[107],"not":[110],"detected":[111],"inmyofibres,":[112],"butwas":[113],"cells.Moreover,":[117],"theage-related":[118],"apoptotic":[121],"essentially":[124],"due":[125]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}