{"id":"https://openalex.org/W7097141971","doi":null,"title":"BENEFICIAL EFFECTS OF DOCOSAHEXAENOIC ACID ON THE BRAIN","display_name":"BENEFICIAL EFFECTS OF DOCOSAHEXAENOIC ACID ON THE BRAIN","publication_year":2016,"publication_date":"2016-10-12","ids":{"openalex":"https://openalex.org/W7097141971"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.984.4271","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.984.4271","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3792211%26blobtype%3Dpdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54302423,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.6140000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.8330000042915344},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/synaptic-function","display_name":"synaptic function","score":0.746999979019165},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"neurotransmission","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7120000123977661},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6869999766349792},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9549999833106995},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.3720000088214874},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.8481000065803528},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5651999711990356},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5213000178337097},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4814999997615814},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4471000134944916},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4284000098705292},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.4255000054836273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39500001072883606},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3874000012874603},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.3833000063896179},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.36820000410079956},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.33550000190734863},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3343000113964081},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.319599986076355},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C2992270614","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Membrane permeability","level":3,"score":0.3102000057697296},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.2953000068664551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29420000314712524},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2888000011444092},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2858000099658966},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.26579999923706055},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C122398194","wikidata":"https://www.wikidata.org/wiki/Q6815129","display_name":"Membrane fluidity","level":3,"score":0.25780001282691956},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.2540000081062317},{"id":"https://openalex.org/C2910644744","wikidata":"https://www.wikidata.org/wiki/Q2643251","display_name":"Synaptic membrane","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.984.4271","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.984.4271","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC3792211%26blobtype%3Dpdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041717775","https://openalex.org/W1998141474","https://openalex.org/W114982249","https://openalex.org/W4224224106","https://openalex.org/W1967951788","https://openalex.org/W2225813084","https://openalex.org/W2479875541","https://openalex.org/W2020118082","https://openalex.org/W3199608017","https://openalex.org/W2228874283"],"abstract_inverted_index":{"Docosahexaenoic":[0],"acid":[1],"(DHA)":[2],"is":[3,11],"an":[4],"important":[5],"component":[6],"of":[7,16,23,43,61,67,84],"neural":[8],"membranes":[9],"and":[10,26,36,52,65,70,91,95,106],"present":[12],"in":[13,19,29,54,112],"30-40":[14],"%":[15],"the":[17,20,30],"phospho-lipids":[18],"gray":[21],"matter":[22],"cerebral":[24],"cortex":[25],"photoreceptor":[27],"cells":[28],"retina.":[31],"It":[32],"mediates":[33],"its":[34],"molecular":[35],"cellular":[37],"effects":[38,108],"not":[39],"only":[40],"through":[41],"regulation":[42],"physicochemical":[44],"properties":[45],"such":[46],"as":[47],"membrane":[48],"fl":[49],"uidity,":[50],"permeability":[51],"viscosity":[53],"syn-aptic":[55],"membranes,":[56],"but":[57],"also":[58],"via":[59],"modulation":[60],"neurotransmis-sion,":[62],"gene":[63],"expression,":[64],"activities":[66],"enzymes,":[68],"receptors":[69],"ion":[71],"channels":[72],"(Fig.":[73,119],"1)":[74,120],"(Farooqui,":[75],"2009).":[76],"These":[77],"processes":[78],"are":[79],"closely":[80],"associated":[81],"with":[82],"activation":[83],"signaling":[85],"pathways":[86],"that":[87],"sustain":[88],"synaptic":[89],"function":[90],"neuronal":[92],"survival":[93],"(Oster":[94],"Pillot,":[96],"2010).":[97],"PUFAs":[98],"including":[99],"DHA":[100],"have":[101],"anti-oxidative":[102],"stress,":[103],"anti-in-fl":[104],"ammation":[105],"anti-apoptosis":[107],"leading":[109],"to":[110],"neuroprotec-tion":[111],"aged,":[113],"damaged":[114],"or":[115],"Alzheimer\u2019s":[116],"disease":[117],"brain":[118]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}