{"id":"https://openalex.org/W7096974823","doi":null,"title":"GUEST EDITORIAL","display_name":"GUEST EDITORIAL","publication_year":2013,"publication_date":"2013-04-03","ids":{"openalex":"https://openalex.org/W7096974823"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.1996","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.1996","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/55/Br_J_Cancer_1992_Sep_66(3)_424-426.tar.gz","raw_type":"text"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108554927","display_name":"Jillian M. Birch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"J. M. Birch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108554927"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-gene","display_name":"p53 gene","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.921999990940094},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.847000002861023},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.968999981880188},{"id":"https://openalex.org/keywords/p53-deletion","display_name":"p53 deletion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cancer-genetics","display_name":"cancer genetics","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5763999819755554},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5598999857902527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5285999774932861},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5049999952316284},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47600001096725464},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.4699000120162964},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4341000020503998},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3409000039100647},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3359000086784363},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.3287999927997589},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29840001463890076},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2563999891281128},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.2533999979496002},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2515000104904175}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.277.1996","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.277.1996","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/55/Br_J_Cancer_1992_Sep_66(3)_424-426.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.1451","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.1451","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/55/Br_J_Cancer_1992_Sep_66(3)_424-426.tar.gz","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7097434941","https://openalex.org/W2962531081","https://openalex.org/W2613080813","https://openalex.org/W4231713391","https://openalex.org/W324016059","https://openalex.org/W134485649","https://openalex.org/W7095456028","https://openalex.org/W97211488","https://openalex.org/W2071063740","https://openalex.org/W1966163762"],"abstract_inverted_index":{"During":[0],"the":[1,8,16,48,67,80],"13":[2],"years":[3],"which":[4],"have":[5,19,45,64],"passed":[6],"since":[7],"p53":[9,17,49,63,83,97],"protein":[10],"was":[11],"first":[12],"identified,":[13],"studies":[14,44],"of":[15,43,82],"gene":[18,50,88,98],"gained":[20],"in":[21,62,73,117],"scientific":[22],"importance,":[23],"leading":[24,78],"to":[25,79,105],"discoveries":[26],"with":[27,54],"major":[28],"clinical":[29],"implications.":[30],"Although":[31],"originally":[32],"classified":[33],"as":[34,66,84],"an":[35],"oncogene,":[36],"more":[37],"recent":[38],"results":[39],"from":[40],"a":[41,55,85],"number":[42],"established":[46],"that":[47],"exhibits":[51],"properties":[52],"conssistent":[53],"tumour":[56,86],"suppressor":[57,87],"gene.":[58],"Mutations":[59,115],"and":[60,109],"deletions":[61],"emerged":[65],"most":[68],"common":[69,104],"genetic":[70],"changes":[71],"found":[72],"cancer":[74],"cells.":[75],"The":[76,96],"events":[77],"classification":[81],"are":[89,120],"reviewed":[90],"by":[91],"Lane":[92],"&":[93],"Benchimol,":[94],"1990.":[95],"includes":[99],"five":[100],"evolutionarily":[101],"conserved":[102],"domains":[103],"mammals,":[106],"amphibians,":[107],"birds":[108],"fish":[110],"(Soussi":[111],"et":[112],"al.,":[113],"1990).":[114],"seen":[116],"sporadic":[118],"tumours":[119]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}
