{"id":"https://openalex.org/W7096940539","doi":null,"title":"The Journal of Experimental Medicine CORRESPONDENCE Oscar Fernandez-Capetillo:","display_name":"The Journal of Experimental Medicine CORRESPONDENCE Oscar Fernandez-Capetillo:","publication_year":2013,"publication_date":"2013-03-28","ids":{"openalex":"https://openalex.org/W7096940539"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.7824","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.7824","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/22/8b/J_Exp_Med_2006_Feb_20_203(2)_297-303.tar.gz","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055584616","display_name":"Myriam Cuadrado","orcid":"https://orcid.org/0000-0001-9410-1205","observed_orcids":["https://orcid.org/0000-0001-9410-1205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myriam Cuadrado","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013693536","display_name":"B\u00e1rbara Mart\u00ednez-Pastor","orcid":"https://orcid.org/0000-0003-0960-1737","observed_orcids":["https://orcid.org/0000-0003-0960-1737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Martinez-pastor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103633205","display_name":"Matilde Murga","orcid":"https://orcid.org/0000-0002-9766-4481","observed_orcids":["https://orcid.org/0000-0002-9766-4481"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matilde Murga","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Luis I. Toledo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis I. Toledo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36745506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ataxia-telangiectasia-mutated","display_name":"ATM kinase","score":0.8320000171661377},{"id":"https://openalex.org/keywords/atr-kinase","display_name":"ATR kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":0.7689999938011169},{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dna-damage-signaling","display_name":"DNA damage signaling","score":0.7059999704360962},{"id":"https://openalex.org/keywords/chromatin-recruitment","display_name":"chromatin recruitment","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7045999765396118},{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.6603000164031982},{"id":"https://openalex.org/C50001416","wikidata":"https://www.wikidata.org/wiki/Q17861750","display_name":"CHEK1","level":5,"score":0.5846999883651733},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5202999711036682},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.49720001220703125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4618000090122223},{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.4611000120639801},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4253999888896942},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4253999888896942},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41850000619888306},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.397599995136261},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3961000144481659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3944999873638153},{"id":"https://openalex.org/C158980903","wikidata":"https://www.wikidata.org/wiki/Q7899329","display_name":"Upstream and downstream (DNA)","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34709998965263367},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.31130000948905945},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3111000061035156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2824999988079071},{"id":"https://openalex.org/C2910325170","wikidata":"https://www.wikidata.org/wiki/Q14912280","display_name":"Checkpoint Kinase 2","level":5,"score":0.2808000147342682},{"id":"https://openalex.org/C2777136964","wikidata":"https://www.wikidata.org/wiki/Q1250362","display_name":"Nijmegen breakage syndrome","level":5,"score":0.27000001072883606},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2542000114917755},{"id":"https://openalex.org/C2992406208","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"Double strand","level":4,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.7824","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.7824","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/22/8b/J_Exp_Med_2006_Feb_20_203(2)_297-303.tar.gz","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149468013","https://openalex.org/W2100817243","https://openalex.org/W2066872018","https://openalex.org/W2114767668","https://openalex.org/W2170965564","https://openalex.org/W28070522","https://openalex.org/W2062284662","https://openalex.org/W2129753373","https://openalex.org/W2058223290","https://openalex.org/W2084745121"],"abstract_inverted_index":{"DNA":[0,192],"double-strand":[1],"breaks":[2],"(DSBs)":[3],"are":[4,58,64],"among":[5],"the":[6,17,20,30,36,59,68,90,120,130],"most":[7],"deleterious":[8],"lesions":[9],"that":[10,33,63,85],"can":[11],"challenge":[12],"genomic":[13],"integrity.":[14],"Concomitant":[15],"to":[16,35,66,117,135,170,191],"repair":[18],"of":[19,38,89,112,119,129,152,167,178],"breaks,":[21],"a":[22,103,110,123],"rapid":[23],"signaling":[24,61,187],"cascade":[25,70],"must":[26],"be":[27],"coordinated":[28],"at":[29,71],"lesion":[31],"site":[32],"leads":[34,116],"activation":[37,118,128],"cell":[39],"cycle":[40],"checkpoints":[41,121],"and/or":[42],"apoptosis.":[43],"In":[44],"this":[45,138,160],"context,":[46],"ataxia":[47],"telangiectasia":[48],"mutated":[49],"(ATM)":[50],"and":[51,53,79,115,148,162,185],"ATM":[52,78,94,147,164,184],"Rad-3\u2013related":[54],"(ATR)":[55],"protein":[56],"kinases":[57],"earliest":[60],"molecules":[62],"known":[65],"initiate":[67],"transduction":[69],"damage":[72],"sites.":[73],"The":[74],"current":[75],"model":[76],"places":[77,163],"ATR":[80,106,149,168,186],"in":[81,109,122,133,189],"separate":[82],"molecular":[83],"routes":[84],"orchestrate":[86],"distinct":[87],"pathways":[88,188],"checkpoint":[91,132],"responses.":[92],"Whereas":[93],"signals":[95],"DSBs":[96,114],"arising":[97],"from":[98],"ionizing":[99],"radiation":[100],"(IR)":[101],"through":[102],"Chk2dependent":[104],"pathway,":[105],"is":[107,143],"activated":[108],"variety":[111],"replication-linked":[113],"Chk1":[124],"kinase\u2013dependent":[125],"manner.":[126],"However,":[127],"G2/M":[131],"response":[134,190],"IR":[136],"escapes":[137],"accepted":[139],"paradigm":[140],"because":[141],"it":[142],"dependent":[144],"on":[145],"both":[146],"but":[150],"independent":[151],"Chk2.":[153],"Our":[154],"data":[155,174],"provides":[156],"an":[157,179],"explanation":[158],"for":[159],"observation":[161],"activity":[165],"upstream":[166],"recruitment":[169],"IR-damaged":[171],"chromatin.":[172],"These":[173],"provide":[175],"experimental":[176],"evidence":[177],"active":[180],"cross":[181],"talk":[182],"between":[183],"damage.":[193]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-27T00:00:00"}