{"id":"https://openalex.org/W7096911059","doi":null,"title":"Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy. PLoS ONE. 2013; 8:e78287. [PubMed: 24205183","display_name":"Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy. PLoS ONE. 2013; 8:e78287. [PubMed: 24205183","publication_year":2016,"publication_date":"2016-08-20","ids":{"openalex":"https://openalex.org/W7096911059"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.1574","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.1574","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ea/29/pone.0078287.PMC3808338.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056392452","display_name":"Wolfgang St\u00f6hr","orcid":"https://orcid.org/0000-0002-6533-2888","observed_orcids":["https://orcid.org/0000-0002-6533-2888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang St\u00f6hr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067056877","display_name":"Sarah J. Fidler","orcid":"https://orcid.org/0000-0003-1676-7583","observed_orcids":["https://orcid.org/0000-0003-1676-7583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah Fidler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Myra Mcclure","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myra Mcclure","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jonathan Weber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Cooper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Cooper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110141057","display_name":"Gita Ramjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gita Ramjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mauro Schechter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mauro Schechter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107873349","display_name":"Abdel G. Babiker","orcid":"https://orcid.org/0000-0003-4711-3021","observed_orcids":["https://orcid.org/0000-0003-4711-3021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdel Babiker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Rodney E. Phillips","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney E. Phillips","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Porter John Frater","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Porter John Frater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39405762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duration-of-antiretroviral-therapy","display_name":"antiretroviral therapy duration","score":0.8920000195503235},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/viral-rebound","display_name":"viral rebound","score":0.7329999804496765},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.7929999828338623},{"id":"https://openalex.org/keywords/plasma-viral-load","display_name":"plasma viral load","score":0.7979999780654907},{"id":"https://openalex.org/keywords/seroconversion","display_name":"seroconversion","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8199999928474426},{"id":"https://openalex.org/C112758219","wikidata":"https://www.wikidata.org/wiki/Q16038819","display_name":"Duration (music)","level":2,"score":0.6728000044822693},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.656499981880188},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.652899980545044},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6413999795913696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5878000259399414},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5514000058174133},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5320000052452087},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.43369999527931213},{"id":"https://openalex.org/C140206745","wikidata":"https://www.wikidata.org/wiki/Q5308895","display_name":"Drug holiday","level":3,"score":0.39149999618530273},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.37220001220703125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35519999265670776},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.3456000089645386},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3409999907016754},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2944999933242798},{"id":"https://openalex.org/C26831200","wikidata":"https://www.wikidata.org/wiki/Q16963953","display_name":"Marginal structural model","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.2800999879837036},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.2800000011920929},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.1574","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.1574","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ea/29/pone.0078287.PMC3808338.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007573365","https://openalex.org/W2553903379","https://openalex.org/W6925184133","https://openalex.org/W2413289711","https://openalex.org/W2074968855","https://openalex.org/W2942485869","https://openalex.org/W4317936397","https://openalex.org/W2611773854","https://openalex.org/W2141943803","https://openalex.org/W2171149970"],"abstract_inverted_index":{"Objective:":[0],"A":[1],"minority":[2],"of":[3,46,56,86,104,124,128,144],"HIV-1":[4,14],"positive":[5],"individuals":[6,41],"treated":[7],"with":[8,60],"antiretroviral":[9],"therapy":[10,88],"(ART)":[11],"in":[12],"primary":[13],"infection":[15],"(PHI)":[16],"maintain":[17],"viral":[18,78],"suppression":[19],"on":[20,134],"stopping.":[21],"Whether":[22],"this":[23],"is":[24],"related":[25],"to":[26,138],"ART":[27,57,92,117,155],"duration":[28,55],"has":[29],"not":[30],"been":[31],"explored.":[32],"Design:":[33],"And":[34],"Methods:":[35],"Using":[36],"SPARTAC":[37],"trial":[38],"data":[39],"from":[40,116],"recruited":[42],"within":[43,113],"6":[44],"months":[45],"seroconversion,":[47],"we":[48],"present":[49],"an":[50],"observational":[51],"analysis":[52],"investigating":[53],"whether":[54],"was":[58,121],"associated":[59],"post-treatment":[61],"viraemic":[62],"control.":[63],"Kaplan-Meier":[64],"estimates,":[65],"logistic":[66],"regression":[67],"and":[68,151],"Cox":[69],"models":[70],"were":[71,157],"used.":[72],"Results:":[73],"165":[74],"participants":[75,109],"reached":[76],"plasma":[77],"loads":[79],"(VL)":[80],"<400":[81,130,146],"copies/ml":[82,99,131,147],"at":[83,148],"the":[84],"time":[85],"stopping":[87],"(ART":[89],"stop).":[90],"After":[91],"stop,":[93,118],"159":[94],"experienced":[95,110],"confirmed":[96],"VL":[97,111],"\u2265400":[98],"during":[100],"median":[101],"(IQR)":[102],"follow-up":[103],"167":[105],"(108,199)":[106],"weeks.":[107],"Most":[108],"rebound":[112],"12":[114],"weeks":[115,136,140,153],"however,":[119],"there":[120],"a":[122,125],"suggestion":[123],"higher":[126],"probability":[127],"remaining":[129,145],"for":[132],"those":[133],"ART>12":[135],"compared":[137],"\u226412":[139],"(p=0.061).":[141],"Cumulative":[142],"probabilities":[143],"12,":[149],"52":[150],"104":[152],"after":[154],"stop":[156],"21%":[158]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-27T00:00:00"}