{"id":"https://openalex.org/W7096900928","doi":null,"title":"OPINION ARTICLE","display_name":"OPINION ARTICLE","publication_year":2016,"publication_date":"2016-09-17","ids":{"openalex":"https://openalex.org/W7096900928"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.895.2098","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.895.2098","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://f1000researchdata.s3.amazonaws.com/manuscripts/4705/600dc913-3c05-4b05-b69c-6746fc653aea_4396%20-%20norman%20miller.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107412310","display_name":"N.E. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Norman E Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5107412310"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51844756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.11240000277757645,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesteryl-ester-transfer-protein","display_name":"cholesteryl ester transfer protein","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cetp-inhibition","display_name":"CETP inhibition","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6349999904632568},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.921999990940094},{"id":"https://openalex.org/keywords/reverse-cholesterol-transport","display_name":"reverse cholesterol transport","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hdl-function","display_name":"HDL function","score":0.8309999704360962},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C45505151","wikidata":"https://www.wikidata.org/wiki/Q424706","display_name":"Cholesterylester transfer protein","level":4,"score":0.9462000131607056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5277000069618225},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4724999964237213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45660001039505005},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4544999897480011},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4440999925136566},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.44029998779296875},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.428600013256073},{"id":"https://openalex.org/C110459506","wikidata":"https://www.wikidata.org/wiki/Q7318217","display_name":"Reverse cholesterol transport","level":4,"score":0.39590001106262207},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.38749998807907104},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3682999908924103},{"id":"https://openalex.org/C3019550498","wikidata":"https://www.wikidata.org/wiki/Q28749","display_name":"Ldl cholesterol","level":3,"score":0.34200000762939453},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.33889999985694885},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.326200008392334},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3122999966144562},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C2993401043","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Plasma lipoprotein","level":4,"score":0.2897000014781952},{"id":"https://openalex.org/C2780541478","wikidata":"https://www.wikidata.org/wiki/Q410020","display_name":"High-density lipoprotein","level":3,"score":0.2736999988555908},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2612000107765198}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.895.2098","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.895.2098","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://f1000researchdata.s3.amazonaws.com/manuscripts/4705/600dc913-3c05-4b05-b69c-6746fc653aea_4396%20-%20norman%20miller.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4234565626","https://openalex.org/W2127608622","https://openalex.org/W2296150925","https://openalex.org/W2808635493","https://openalex.org/W2009220054","https://openalex.org/W1985322784","https://openalex.org/W2029253708","https://openalex.org/W2040846794","https://openalex.org/W2187412430","https://openalex.org/W1969260244"],"abstract_inverted_index":{"Inhibition":[0],"of":[1,88,112,150],"cholesteryl":[2],"ester":[3],"transfer":[4],"protein":[5],"(CETP)":[6],"lowers":[7],"plasma":[8,104],"low-density":[9],"lipoprotein":[10,16],"cholesterol":[11,46],"concentration":[12],"and":[13,44,131,135],"raises":[14],"high-density":[15],"(HDL)":[17],"cholesterol,":[18],"suggesting":[19],"it":[20],"might":[21],"prevent":[22],"cardiovascular":[23],"disease":[24],"(CVD).":[25],"From":[26],"the":[27,30,63,83,151],"outset,":[28],"however,":[29],"concept":[31],"has":[32,51,106],"been":[33,53,108],"controversial":[34],"owing":[35],"to":[36,103],"uncertainty":[37],"about":[38],"its":[39],"effects":[40],"on":[41,66,124],"HDL":[42],"function":[43],"reverse":[45],"transport":[47],"(RCT).":[48],"Although":[49],"there":[50],"long":[52],"good":[54],"evidence":[55],"that":[56,97,153],"CETP":[57,67,90,105,156],"inhibition":[58],"reduces":[59],"atherosclerosis":[60],"in":[61,73,110,122],"rabbits,":[62],"first":[64,84,130],"information":[65],"as":[68,138,140],"a":[69,74,89],"CVD":[70,98,133,141],"risk":[71],"factor":[72],"prospectively":[75],"followed":[76],"cohort":[77,116],"was":[78,100],"not":[79],"published":[80],"until":[81],"after":[82],"Phase":[85],"3":[86],"trial":[87],"inhibitor":[91],"had":[92],"begun.":[93],"The":[94],"worrying":[95],"finding":[96],"incidence":[99],"related":[101],"inversely":[102],"since":[107],"reproduced":[109],"each":[111],"five":[113],"further":[114],"prospective":[115],"studies.":[117],"Similar":[118],"results":[119],"were":[120],"obtained":[121],"subjects":[123],"or":[125],"off":[126],"statin":[127],"therapy,":[128],"for":[129,136],"second":[132],"events,":[134],"mortality":[137],"well":[139],"morbidity.":[142],"Additionally,":[143],"two":[144],"recent":[145],"studies":[146],"have":[147],"found":[148],"alleles":[149],"gene":[152],"lower":[154],"hepatic":[155],"secretionCETP":[157]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}
