{"id":"https://openalex.org/W7096885196","doi":"https://doi.org/10.1101/lm.2.6.320","title":"Effects of a conditional Drosophila PKA mutant on olfactory learning and memory.","display_name":"Effects of a conditional Drosophila PKA mutant on olfactory learning and memory.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W7096885196","doi":"https://doi.org/10.1101/lm.2.6.320","pmid":"https://pubmed.ncbi.nlm.nih.gov/10467582"},"language":"en","primary_location":{"id":"doi:10.1101/lm.2.6.320","doi":"https://doi.org/10.1101/lm.2.6.320","is_oa":true,"landing_page_url":"https://doi.org/10.1101/lm.2.6.320","pdf_url":"http://learnmem.cshlp.org/content/2/6/320.full.pdf","source":{"id":"https://openalex.org/S73374563","display_name":"Learning & Memory","issn_l":"1072-0502","issn":["1072-0502","1549-5485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Learning & Memory","raw_type":"journal-article"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://learnmem.cshlp.org/content/2/6/320.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059403398","display_name":"Willis X. Li","orcid":"https://orcid.org/0000-0001-9041-7341","observed_orcids":["https://orcid.org/0000-0001-9041-7341"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W Li","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, New York 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, New York 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108006038","display_name":"Tim Tully","orcid":"https://orcid.org/0000-0002-2058-9073","observed_orcids":["https://orcid.org/0000-0002-2058-9073"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Tully","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, New York 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, New York 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":null,"display_name":"D Kalderon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Kalderon","raw_affiliation_strings":["Department of Biological Sciences, Columbia University, New York, New York 10027, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Columbia University, New York, New York 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"6","first_page":"320","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9850000143051147},{"id":"https://openalex.org/keywords/classical-conditioning","display_name":"classical conditioning","score":0.7710000276565552},{"id":"https://openalex.org/keywords/memory-decay","display_name":"memory decay","score":0.734000027179718},{"id":"https://openalex.org/keywords/associative-learning","display_name":"associative learning","score":0.6980000138282776},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6825000047683716},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6216999888420105},{"id":"https://openalex.org/C2983526489","wikidata":"https://www.wikidata.org/wiki/Q133500","display_name":"Associative learning","level":2,"score":0.5388000011444092},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5026000142097473},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4731000065803528},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.43479999899864197},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4278999865055084},{"id":"https://openalex.org/C2779980732","wikidata":"https://www.wikidata.org/wiki/Q24774756","display_name":"Olfactory receptor","level":3,"score":0.414900004863739},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.400299996137619},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3562999963760376},{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.3481000065803528},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3361000120639801},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3359000086784363},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3203999996185303},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.3163999915122986},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.30469998717308044},{"id":"https://openalex.org/C2993691153","wikidata":"https://www.wikidata.org/wiki/Q492","display_name":"Memory formation","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2948000133037567},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.27900001406669617},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.27000001072883606},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2567000091075897}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1101/lm.2.6.320","doi":"https://doi.org/10.1101/lm.2.6.320","is_oa":true,"landing_page_url":"https://doi.org/10.1101/lm.2.6.320","pdf_url":"http://learnmem.cshlp.org/content/2/6/320.full.pdf","source":{"id":"https://openalex.org/S73374563","display_name":"Learning & Memory","issn_l":"1072-0502","issn":["1072-0502","1549-5485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Learning & Memory","raw_type":"journal-article"},{"id":"pmid:10467582","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10467582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Learning & memory (Cold Spring Harbor, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1029.6310","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1029.6310","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://learnmem.cshlp.org/content/2/6/320.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1101/lm.2.6.320","doi":"https://doi.org/10.1101/lm.2.6.320","is_oa":true,"landing_page_url":"https://doi.org/10.1101/lm.2.6.320","pdf_url":"http://learnmem.cshlp.org/content/2/6/320.full.pdf","source":{"id":"https://openalex.org/S73374563","display_name":"Learning & Memory","issn_l":"1072-0502","issn":["1072-0502","1549-5485"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Learning & Memory","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2762702337","display_name":"Hedgehog signaling in Drosophila","funder_award_id":"R01GM041815","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3330778113","display_name":null,"funder_award_id":"GM-41815","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7096885196.pdf","grobid_xml":"https://content.openalex.org/works/W7096885196.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W44106782","https://openalex.org/W75664332","https://openalex.org/W170283987","https://openalex.org/W1483803290","https://openalex.org/W1491836751","https://openalex.org/W1527707083","https://openalex.org/W1533422392","https://openalex.org/W1676103704","https://openalex.org/W1722211492","https://openalex.org/W1917049701","https://openalex.org/W1917569852","https://openalex.org/W1953170446","https://openalex.org/W1965635919","https://openalex.org/W1965815102","https://openalex.org/W1966631841","https://openalex.org/W1970706920","https://openalex.org/W1972188808","https://openalex.org/W1973435759","https://openalex.org/W1973707586","https://openalex.org/W1974223005","https://openalex.org/W1976344568","https://openalex.org/W1978274173","https://openalex.org/W1979252107","https://openalex.org/W1988189113","https://openalex.org/W1988311363","https://openalex.org/W1988694109","https://openalex.org/W1990499518","https://openalex.org/W1990589909","https://openalex.org/W1991445188","https://openalex.org/W1992002970","https://openalex.org/W1999160588","https://openalex.org/W1999643558","https://openalex.org/W2000389793","https://openalex.org/W2001560475","https://openalex.org/W2003861265","https://openalex.org/W2010206241","https://openalex.org/W2010980507","https://openalex.org/W2011420167","https://openalex.org/W2021503948","https://openalex.org/W2022374934","https://openalex.org/W2023768940","https://openalex.org/W2023796149","https://openalex.org/W2028242823","https://openalex.org/W2031704980","https://openalex.org/W2037377049","https://openalex.org/W2051584218","https://openalex.org/W2051616273","https://openalex.org/W2055829187","https://openalex.org/W2058082452","https://openalex.org/W2060496335","https://openalex.org/W2065829059","https://openalex.org/W2076782084","https://openalex.org/W2078192383","https://openalex.org/W2078962110","https://openalex.org/W2082350440","https://openalex.org/W2083751364","https://openalex.org/W2083983571","https://openalex.org/W2088335423","https://openalex.org/W2088349471","https://openalex.org/W2094046904","https://openalex.org/W2104119127","https://openalex.org/W2125141239","https://openalex.org/W2128635872","https://openalex.org/W2144393631","https://openalex.org/W2145330934","https://openalex.org/W2153367976","https://openalex.org/W2154627422","https://openalex.org/W2159334577","https://openalex.org/W2167076540","https://openalex.org/W2174425677","https://openalex.org/W2318185954","https://openalex.org/W4236083179","https://openalex.org/W4244537630"],"related_works":["https://openalex.org/W2061961323","https://openalex.org/W2010980507","https://openalex.org/W2082350440","https://openalex.org/W2041902497","https://openalex.org/W2003154634","https://openalex.org/W2171113596","https://openalex.org/W4235055140","https://openalex.org/W7097443054","https://openalex.org/W1973617706","https://openalex.org/W1756891078"],"abstract_inverted_index":{"The":[0],"requirement":[1],"for":[2,18,153],"cAMP-dependent":[3],"protein":[4],"kinase":[5],"(PKA)":[6],"in":[7,14,73,102,129,136,143,155,159,166],"associative":[8],"learning":[9,94,106,124],"of":[10,23,33,80,150],"Drosophila":[11],"was":[12],"assessed":[13],"mutant":[15],"flies":[16],"hemizygous":[17],"a":[19,71,103,126,137,151],"cold-sensitive":[20],"allele,":[21],"X4,":[22],"the":[24,29,45,109],"DC0":[25],"gene,":[26],"which":[27],"encodes":[28],"major":[30],"catalytic":[31],"subunit":[32],"PKA.":[34],"DC0X4":[35,59,89,130,144],"hemizygotes":[36,60,90,131],"died":[37],"as":[38],"third-instar":[39],"larvae":[40],"at":[41,53],"18":[42,66,116],"degrees":[43,55,63,67,87,113,117],"C,":[44,88],"restrictive":[46],"temperature,":[47],"but":[48,98,134],"were":[49],"viable":[50],"when":[51],"raised":[52],"25":[54,62,86,112],"C.":[56],"Shifting":[57,108],"adult":[58],"from":[61,76,111],"C":[64,68,114,118],"to":[65,70,78,96,115,120,125,161],"led":[69],"decrease":[72],"PKA":[74,154],"activity":[75],"24%":[77],"16%":[79],"wild-type":[81],"without":[82],"impairing":[83],"viability.":[84],"At":[85],"exhibited":[91],"reduced":[92,122],"initial":[93,123,167],"relative":[95],"controls":[97,133],"normal":[99],"memory":[100,139,157],"decay":[101,140],"Pavlovian":[104],"olfactory":[105],"assay.":[107],"temperature":[110],"prior":[119],"training":[121],"similar":[127],"extent":[128],"and":[132],"resulted":[135],"steeper":[138],"curve":[141],"only":[142],"hemizygotes.":[145],"These":[146],"observations":[147],"are":[148],"suggestive":[149],"role":[152,165],"medium-term":[156],"formation":[158],"addition":[160],"its":[162],"previously":[163],"established":[164],"learning.":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}