{"id":"https://openalex.org/W7096873752","doi":null,"title":"INTRODUCTION: A RATIONALE FOR AD VECTOR TARGETING","display_name":"INTRODUCTION: A RATIONALE FOR AD VECTOR TARGETING","publication_year":2013,"publication_date":"2013-08-22","ids":{"openalex":"https://openalex.org/W7096873752"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.5494","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.5494","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.benthamscience.com/cgt/openaccessarticles/cgt7-3/0004Q.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082944335","display_name":"Samuel K. Campos","orcid":"https://orcid.org/0000-0003-1540-9821","observed_orcids":["https://orcid.org/0000-0003-1540-9821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel K. Campos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Michael A. Barry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Barry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43446291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/vector-targeting","display_name":"vector targeting","score":0.6880000233650208},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7369999885559082},{"id":"https://openalex.org/keywords/structure-function-relationship","display_name":"structure-function relationship","score":0.8920000195503235},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/viral-vector-development","display_name":"viral vector development","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.7444999814033508},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5012999773025513},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.48179998993873596},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44859999418258667},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4056999981403351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.335099995136261},{"id":"https://openalex.org/C43953973","wikidata":"https://www.wikidata.org/wiki/Q7917858","display_name":"Vectors in gene therapy","level":5,"score":0.32829999923706055},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.2912999987602234},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2624000012874603}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.5494","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.5494","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.benthamscience.com/cgt/openaccessarticles/cgt7-3/0004Q.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025616153","https://openalex.org/W2000070203","https://openalex.org/W4245063315","https://openalex.org/W64058586","https://openalex.org/W2127342759","https://openalex.org/W2186505304","https://openalex.org/W4405452247","https://openalex.org/W4233298146","https://openalex.org/W4236449906","https://openalex.org/W2040558709"],"abstract_inverted_index":{"Abstract:":[0],"Gene":[1],"delivery":[2],"vectors":[3,8,42,67,117],"based":[4],"on":[5],"Adenoviral":[6],"(Ad)":[7],"have":[9],"enormous":[10],"potential":[11],"for":[12,68],"the":[13,25,37,57,89,100,112,123],"treatment":[14],"of":[15,24,36,56,59,65,80,91,102,111],"both":[16],"hereditary":[17],"and":[18,43,46,82,118,121],"acquired":[19],"disease.":[20],"Detailed":[21],"structural":[22],"analysis":[23],"Ad":[26,41,60,66,85,103,116,129],"virion,":[27],"combined":[28],"with":[29],"functional":[30],"studies":[31],"has":[32,49,93],"broadened":[33],"our":[34],"knowledge":[35],"structure/function":[38,113],"relationships":[39,114],"between":[40,115],"host":[44,119],"cells/tissues":[45],"substantial":[47],"achievement":[48],"been":[50],"made":[51],"towards":[52,127],"a":[53,96,109],"thorough":[54],"understanding":[55],"biology":[58],"vectors.":[61],"The":[62,78],"widespread":[63],"use":[64],"clinical":[69],"gene":[70],"therapy":[71],"is":[72],"compromised":[73],"by":[74],"their":[75],"inherent":[76],"immunogenicity.":[77],"generation":[79],"safer":[81],"more":[83],"effective":[84],"vectors,":[86],"targeted":[87],"to":[88],"site":[90],"disease,":[92],"therefore":[94],"become":[95],"great":[97],"ambition":[98],"in":[99],"field":[101],"vector":[104,130],"development.":[105],"This":[106],"review":[107],"provides":[108],"synopsis":[110],"systems":[120],"summarizes":[122],"many":[124],"innovative":[125],"approaches":[126],"achieving":[128],"targeting.":[131]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-27T00:00:00"}