{"id":"https://openalex.org/W7096775002","doi":null,"title":"AUC Area under the concentration-time curve","display_name":"AUC Area under the concentration-time curve","publication_year":2014,"publication_date":"2014-01-29","ids":{"openalex":"https://openalex.org/W7096775002"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.412.8193","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.412.8193","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.facm.ucl.ac.be/Full-texts-FACM/Vanbambeke-2006-1.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019102142","display_name":"Fran\u00e7oise Van Bambeke A","orcid":"https://orcid.org/0000-0002-0052-7991","observed_orcids":["https://orcid.org/0000-0002-0052-7991"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Van Bambeke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042922540","display_name":"Maritza Barcia-Macay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maritza Barcia-macay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152585576","display_name":"Rine Lemaire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rine Lemaire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Paul M","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul M","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Unit\u00e9 Pharmacologie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Unit\u00e9 Pharmacologie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Cellulaire Mol\u00e9culaire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cellulaire Mol\u00e9culaire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Peak Plasma Concentration","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peak Plasma Concentration","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50458517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/area-under-the-concentration-time-curve","display_name":"area under the concentration-time curve","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cellular-pharmacokinetics","display_name":"cellular pharmacokinetics","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7929999828338623},{"id":"https://openalex.org/keywords/intracellular-drug-accumulation","display_name":"intracellular drug accumulation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/intracellular-infection","display_name":"intracellular infection","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.8385999798774719},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.8082000017166138},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7278000116348267},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.6572999954223633},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6223999857902527},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.5202999711036682},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49549999833106995},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4352000057697296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.375},{"id":"https://openalex.org/C2113261","wikidata":"https://www.wikidata.org/wiki/Q2914458","display_name":"Extracellular fluid","level":3,"score":0.35280001163482666},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3424000144004822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3384999930858612},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3131999969482422},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.29989999532699585},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.2890999913215637},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.28619998693466187},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.2646999955177307},{"id":"https://openalex.org/C79410662","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose\u2013response relationship","level":2,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.412.8193","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.412.8193","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.facm.ucl.ac.be/Full-texts-FACM/Vanbambeke-2006-1.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1761247443","https://openalex.org/W2064809559","https://openalex.org/W2352850341","https://openalex.org/W2064712422","https://openalex.org/W7098018985","https://openalex.org/W2162573988","https://openalex.org/W2733016838","https://openalex.org/W2014674546","https://openalex.org/W2009691949","https://openalex.org/W2047195572"],"abstract_inverted_index":{"The":[0],"treatment":[1],"of":[2,8,27,77,80,101],"intracellular":[3,40,55,99],"infections":[4],"requires":[5],"the":[6,24,49,68,78,90,98],"use":[7],"antibiotics":[9,53,102],"presenting":[10],"appropriate":[11,104],"cellular":[12,28],"pharmacokinetic":[13],"and":[14,31,63],"pharmacodynamic":[15],"properties.":[16],"These":[17],"properties,":[18],"however,":[19],"cannot":[20],"be":[21],"predicted":[22],"on":[23],"simple":[25],"basis":[26],"drug":[29],"accumulation":[30],"minimum":[32],"inhibitory":[33],"concentration":[34],"in":[35,86,103],"broth.":[36],"In":[37],"most":[38],"cases,":[39],"activity":[41,82,100],"is":[42],"actually":[43],"lower":[44],"than":[45,67],"extracellular":[46,69],"activity,":[47],"despite":[48],"fact":[50],"that":[51,57],"all":[52],"reach":[54],"concentrations":[56],"are":[58],"at":[59],"least":[60],"equal":[61],"to,":[62],"more":[64],"often":[65],"higher":[66],"concentrations.":[70],"This":[71],"discrepancy":[72],"may":[73],"result":[74],"from":[75],"impairment":[76],"expression":[79],"antibiotic":[81],"or":[83],"a":[84],"change":[85],"bacterial":[87],"responsiveness":[88],"inside":[89],"cells.":[91],"It":[92],"therefore":[93],"appears":[94],"important":[95],"to":[96],"evaluate":[97],"models.":[105]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}
