{"id":"https://openalex.org/W7096589783","doi":null,"title":"Chair's Summary","display_name":"Chair's Summary","publication_year":null,"publication_date":null,"ids":{"openalex":"https://openalex.org/W7096589783"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.506.3898","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.506.3898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://users.path.ox.ac.uk/~jraff/paper pdfs/peel et al., cb 2007.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145554436","display_name":"De Novo Formation","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"De Novo Formation","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071679094","display_name":"Nina Peel","orcid":"https://orcid.org/0000-0002-4277-4106","observed_orcids":["https://orcid.org/0000-0002-4277-4106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nina Peel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027117954","display_name":"Naomi R. Stevens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naomi R. Stevens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058396316","display_name":"Renata Basto","orcid":"https://orcid.org/0000-0001-5556-2770","observed_orcids":["https://orcid.org/0000-0001-5556-2770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata Basto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centriole-replication","display_name":"centriole replication","score":0.9990000128746033},{"id":"https://openalex.org/keywords/centrosome","display_name":"centrosome","score":0.7630000114440918},{"id":"https://openalex.org/keywords/sak","display_name":"SAK","score":0.7609999775886536},{"id":"https://openalex.org/keywords/centriole-number","display_name":"centriole number","score":0.625},{"id":"https://openalex.org/keywords/drosophila-embryo","display_name":"Drosophila embryo","score":0.7239999771118164},{"id":"https://openalex.org/keywords/spermatocytes","display_name":"spermatocytes","score":0.6169999837875366},{"id":"https://openalex.org/keywords/unfertilized-eggs","display_name":"unfertilized eggs","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pericentriolar-matrix","display_name":"pericentriolar matrix","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C48342290","wikidata":"https://www.wikidata.org/wiki/Q178355","display_name":"Centriole","level":3,"score":0.9702000021934509},{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.8328999876976013},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7473999857902527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6233999729156494},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.5088000297546387},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.4675000011920929},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.42829999327659607},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.35929998755455017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32679998874664307},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30480000376701355},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.30309998989105225},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.29820001125335693},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C44064316","wikidata":"https://www.wikidata.org/wiki/Q5063037","display_name":"Centrosome cycle","level":5,"score":0.27720001339912415},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.25920000672340393}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.506.3898","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.506.3898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://users.path.ox.ac.uk/~jraff/paper pdfs/peel et al., cb 2007.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2126655590","https://openalex.org/W2033638960","https://openalex.org/W1996424319","https://openalex.org/W2157443774","https://openalex.org/W2035835023","https://openalex.org/W2058537133","https://openalex.org/W4225563649","https://openalex.org/W2078073456","https://openalex.org/W3174229494","https://openalex.org/W2102532917"],"abstract_inverted_index":{"many":[0,138],"aspects":[1],"of":[2,21,24,43,75,81,115,123,126,137,140,159,165,173,182,206,218,232],"cell":[3,87],"organization,":[4],"and":[5,10,32,58],"aberrations":[6],"in":[7,55,66,94,110,131,143,185,198,221,238],"their":[8,33],"number":[9,164],"function":[11],"are":[12,235],"associated":[13],"with":[14],"various":[15],"diseases,":[16],"including":[17],"cancer.":[18],"Centrosomes":[19],"consist":[20],"a":[22,28,85],"pair":[23],"centrioles":[25,108,184],"surrounded":[26],"by":[27],"pericentriolar":[29],"matrix":[30],"(PCM),":[31],"replication":[34,54,65,83,194],"is":[35,195],"tightly":[36],"regulated.":[37],"Here,":[38],"we":[39,70],"investigate":[40],"the":[41,45,73,121,132,157,163,180,204,214,230,239],"effects":[42],"overexpressing":[44],"three":[46,117,128],"proteins":[47,129],"known":[48],"to":[49],"be":[50],"required":[51],"for":[52],"centriole":[53,64,170,193],"Drosophila\u2014DSas-6,":[56],"DSas-4,":[57,207],"Sak.":[59],"Results:":[60],"By":[61],"directly":[62],"observing":[63],"living":[67],"Drosophila":[68,222],"embryos,":[69],"show":[71],"that":[72,97,112,156,192,203,225,234],"overex-pression":[74],"GFP-DSas-6":[76,100],"can":[77,178,211],"drive":[78],"extra":[79,107,183],"rounds":[80],"cen-triole":[82],"within":[84],"single":[86],"cycle.":[88],"Extra":[89],"centri-ole-like":[90],"structures":[91,142,220],"also":[92],"accumulate":[93,109],"brain":[95],"cells":[96],"overexpress":[98,113],"either":[99,174],"or":[101,176,209],"GFP-Sak,":[102],"but":[103,188],"not":[104,149,189],"DSas-4-GFP.":[105],"No":[106],"sper-matocytes":[111],"any":[114,124],"these":[116,127],"proteins.":[118],"Most":[119],"remarkably,":[120],"overexpression":[122,205],"one":[125],"results":[130,228],"rapid":[133],"de":[134,215],"novo":[135,216],"forma-tion":[136],"hundreds":[139],"centriole-like":[141,219],"un-fertilized":[144],"eggs,":[145],"which":[146],"normally":[147,236],"do":[148],"contain":[150],"centrioles.":[151],"Conclusions:":[152],"Our":[153],"data":[154],"suggest":[155],"levels":[158],"cen-triolar":[160],"DSas-6":[161,175],"determine":[162],"daughter":[166],"centri-oles":[167],"formed":[168],"during":[169],"replication.":[171],"Overexpres-sion":[172],"Sak":[177,210],"induce":[179,213],"formation":[181,217],"some":[186],"tissues":[187],"others,":[190],"sug-gesting":[191],"regulated":[196],"differently":[197],"different":[199],"tissues.":[200],"The":[201],"finding":[202],"DSas-6,":[208],"rapidly":[212],"eggs":[223],"suggests":[224],"this":[226],"process":[227],"from":[229],"stabili-zation":[231],"centriole-precursors":[233],"present":[237],"egg.":[240]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-27T00:00:00"}