{"id":"https://openalex.org/W7096582276","doi":null,"title":"PERSPECTIVES A","display_name":"PERSPECTIVES A","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W7096582276"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.862.522","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.862.522","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://science.sciencemag.org/content/sci/341/6152/1354.full.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3664816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9210000038146973},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8379999995231628},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/pirb","display_name":"PirB","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lilrb2","display_name":"LILRB2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.6909999847412109},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9300000071525574},{"id":"https://openalex.org/keywords/synapse-loss","display_name":"synaptic loss","score":0.984000027179718},{"id":"https://openalex.org/keywords/neuronal-signaling","display_name":"neuronal signaling","score":0.46799999475479126},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.607699990272522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5552999973297119},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47200000286102295},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.46230000257492065},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4221999943256378},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4205000102519989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38040000200271606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3790000081062317},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3677999973297119},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3411000072956085},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.31949999928474426},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.30480000376701355},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C2911029443","wikidata":"https://www.wikidata.org/wiki/Q21296145","display_name":"Human proteins","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29409998655319214},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2988867146","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Human disease","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.2791999876499176},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2535000145435333}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.862.522","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.862.522","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://science.sciencemag.org/content/sci/341/6152/1354.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965552543","https://openalex.org/W1975832858","https://openalex.org/W2004819007","https://openalex.org/W7097329428","https://openalex.org/W2916287354","https://openalex.org/W4390653305","https://openalex.org/W2312871312","https://openalex.org/W2058016020","https://openalex.org/W4311153966","https://openalex.org/W3164181552"],"abstract_inverted_index":{"lthough":[0],"genetic":[1],"evidence":[2],"puts":[3],"the":[4,47,73,91],"amyloid":[5],"peptide":[6],"(\u03b2-amyloid":[7],"or":[8],"A\u03b2)":[9],"center":[10],"stage":[11],"in":[12,83],"Alzheimer\u2019s":[13],"disease":[14],"(AD),":[15],"it":[16],"remains":[17],"far":[18],"from":[19],"clear":[20],"how":[21],"this":[22,35],"4-kD":[23],"protein":[24],"fragment":[25],"compromises":[26,72],"neuronal":[27],"function":[28],"(":[29,62],"1).":[30],"On":[31],"page":[32],"1399":[33],"of":[34,76,87],"issue,":[36],"Kim":[37],"et":[38],"al.":[39],"identify":[40],"two":[41],"new":[42],"receptors":[43],"for":[44],"aggre-gated":[45],"A\u03b2:":[46],"mouse":[48,85],"paired":[49],"immunoglobulin-like":[50,59],"receptor":[51,60],"B":[52],"(PirB)":[53],"and":[54,78,94],"its":[55],"human":[56],"ortho-log,":[57],"leukocyte":[58],"LilrB2":[61,95],"2).":[63],"The":[64],"binding":[65],"interaction":[66],"triggers":[67],"a":[68,84],"signaling":[69],"cascade":[70],"that":[71],"actin":[74],"cytoskeleton":[75],"neurons":[77],"ultimately":[79],"causes":[80],"synaptic":[81],"loss":[82],"model":[86],"AD.":[88],"PirB":[89],"(see":[90],"fi":[92],"gure)":[93],"are":[96],"non-":[97]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}