{"id":"https://openalex.org/W7096530069","doi":null,"title":"Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni","display_name":"Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni","publication_year":2013,"publication_date":"2013-09-26","ids":{"openalex":"https://openalex.org/W7096530069"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.3808","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.3808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7d/1a/PLoS_Negl_Trop_Dis_2009_Aug_18_3(8)_e504.tar.gz","raw_type":"text"},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5145648383","display_name":"Ra D. Melman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ra D. Melman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044889495","display_name":"Michelle L. Steinauer","orcid":"https://orcid.org/0000-0002-3745-2401","observed_orcids":["https://orcid.org/0000-0002-3745-2401"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michelle L. Steinauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102968198","display_name":"Charles Cunningham","orcid":"https://orcid.org/0000-0003-4151-9362","observed_orcids":["https://orcid.org/0000-0003-4151-9362"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Cunningham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080396236","display_name":"Laura Salter Kubatko","orcid":"https://orcid.org/0000-0002-5215-7144","observed_orcids":["https://orcid.org/0000-0002-5215-7144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura S. Kubatko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144788717","display_name":"N H Mohamed Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ibrahim N","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067235194","display_name":"Nirvana Barker Wynn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nirvana Barker Wynn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112492265","display_name":"Martin W. Mutuku","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin W. Mutuku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107857548","display_name":"Diana M. S. Karanja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana M. S. Karanja","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065415451","display_name":"Daniel G. Colley","orcid":"https://orcid.org/0000-0002-9381-8420","observed_orcids":["https://orcid.org/0000-0002-9381-8420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel G. Colley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144938161","display_name":"Carla L","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carla L","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076715795","display_name":"William Evan Secor","orcid":"https://orcid.org/0000-0003-0584-5961","observed_orcids":["https://orcid.org/0000-0003-0584-5961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Evan Secor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002028028","display_name":"Gerald M. Mkoji","orcid":"https://orcid.org/0000-0003-3417-1644","observed_orcids":["https://orcid.org/0000-0003-3417-1644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald M. Mkoji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066024138","display_name":"Eric S. Loker","orcid":"https://orcid.org/0000-0002-2916-9868","observed_orcids":["https://orcid.org/0000-0002-2916-9868"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric S. Loker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4434579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9380000233650208},{"id":"https://openalex.org/keywords/praziquantel","display_name":"praziquantel","score":0.9229999780654907},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9139999747276306},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/miracidia","display_name":"miracidia","score":0.703000009059906},{"id":"https://openalex.org/keywords/adult-worms","display_name":"adult worms","score":0.7269999980926514},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.5839999914169312},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C2779744950","wikidata":"https://www.wikidata.org/wiki/Q424145","display_name":"Praziquantel","level":4,"score":0.9682999849319458},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.8992000222206116},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.781499981880188},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7297000288963318},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6735000014305115},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.633899986743927},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5175999999046326},{"id":"https://openalex.org/C187651312","wikidata":"https://www.wikidata.org/wiki/Q114","display_name":"Kenya","level":2,"score":0.4700999855995178},{"id":"https://openalex.org/C2779726973","wikidata":"https://www.wikidata.org/wiki/Q578994","display_name":"Helminthiasis","level":2,"score":0.4611999988555908},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4390000104904175},{"id":"https://openalex.org/C2778491710","wikidata":"https://www.wikidata.org/wiki/Q1457418","display_name":"Schistosoma","level":5,"score":0.39160001277923584},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C2776908094","wikidata":"https://www.wikidata.org/wiki/Q572294","display_name":"Anthelmintic","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3441999852657318},{"id":"https://openalex.org/C2778359929","wikidata":"https://www.wikidata.org/wiki/Q207547","display_name":"Trematoda","level":3,"score":0.3400999903678894},{"id":"https://openalex.org/C2992926266","wikidata":"https://www.wikidata.org/wiki/Q609370","display_name":"Adult male","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2590000033378601}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.3808","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.3808","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7d/1a/PLoS_Negl_Trop_Dis_2009_Aug_18_3(8)_e504.tar.gz","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2013711392","https://openalex.org/W7097828851","https://openalex.org/W2006300406","https://openalex.org/W2187144093","https://openalex.org/W7170041270","https://openalex.org/W2292312332","https://openalex.org/W2074665106","https://openalex.org/W4294232824","https://openalex.org/W2073987761","https://openalex.org/W2343648226"],"abstract_inverted_index":{"Background:":[0],"The":[1,176],"near":[2],"exclusive":[3],"use":[4],"of":[5,10,20,30,32,48,111,148,173,186],"praziquantel":[6],"(PZQ)":[7],"for":[8],"treatment":[9,110],"human":[11,96],"schistosomiasis":[12],"has":[13],"raised":[14],"concerns":[15],"about":[16],"the":[17,89,112,151,197],"possible":[18],"emergence":[19],"drug-resistant":[21],"schistosomes.":[22],"Methodology/Principal":[23],"Findings:":[24],"We":[25,57],"measured":[26],"susceptibility":[27,105],"to":[28,43,100,123,158,190],"PZQ":[29,101,124,159],"isolates":[31,163],"Schistosoma":[33],"mansoni":[34],"obtained":[35],"from":[36,38,86,95,129,164,193],"patients":[37,97],"Kisumu,":[39],"Kenya":[40,168],"continuously":[41],"exposed":[42,99],"infection":[44],"as":[45,51],"a":[46,130],"consequence":[47],"their":[49],"occupations":[50],"car":[52],"washers":[53],"or":[54],"sand":[55],"harvesters.":[56],"used":[58],"a)":[59],"an":[60,67,78,144],"in":[61,68,74,79,92,102,145,167,177],"vitro":[62,80,178],"assay":[63,70,81,147],"with":[64,108,114],"miracidia,":[65],"b)":[66],"vivo":[69,146],"targeting":[71,82],"adult":[72,83,149,179],"worms":[73],"mice":[75],"and":[76,125,169,191],"c)":[77],"schistosomes":[84],"perfused":[85],"mice.":[87],"In":[88,143],"miracidia":[90,94],"assay,":[91,180],"which":[93],"were":[98],"vitro,":[103],"reduced":[104],"was":[106,120,140,154],"associated":[107],"previous":[109],"patient":[113,131],"PZQ.":[115],"One":[116],"isolate":[117,153],"(\u2018\u2018KCW\u2019\u2019)":[118],"that":[119,196],"less":[121,156],"susceptible":[122,157],"had":[126,133],"been":[127],"derived":[128],"who":[132],"never":[134],"fully":[135],"cured":[136],"despite":[137],"multiple":[138],"treatments":[139],"studied":[141],"further.":[142],"worms,":[150],"KCW":[152,198],"significantly":[155],"than":[160],"two":[161,170],"other":[162],"natural":[165],"infections":[166],"lab-reared":[171],"strains":[172],"S.":[174],"mansoni.":[175],"based":[181],"on":[182],"measuring":[183],"length":[184],"changes":[185],"adults":[187],"following":[188],"exposure":[189],"recovery":[192],"PZQ,":[194],"confirmed":[195]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-27T00:00:00"}