{"id":"https://openalex.org/W70965044","doi":null,"title":"Role of oxidative stress in the pathogenesis of chronic hepatitis C (CHC).","display_name":"Role of oxidative stress in the pathogenesis of chronic hepatitis C (CHC).","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W70965044","mag":"70965044","pmid":"https://pubmed.ncbi.nlm.nih.gov/19690766"},"language":"en","primary_location":{"id":"pmid:19690766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19690766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039036528","display_name":"Carmen Georgeta Fierbinteanu-Braticevici","orcid":"https://orcid.org/0000-0001-8863-3301","observed_orcids":["https://orcid.org/0000-0001-8863-3301"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Carmen Fierbin\u0163eanu-Braticevici","raw_affiliation_strings":["Medical Clinic II and Gastroenterology, University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cfierbinteanu@yahoo.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Clinic II and Gastroenterology, University Emergency Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. cfierbinteanu@yahoo.com","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113774845","display_name":"Maria Mohora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Mohora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026705198","display_name":"Drago\u015f Cre\u021boiu","orcid":"https://orcid.org/0000-0003-3214-030X","observed_orcids":["https://orcid.org/0000-0003-3214-030X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Cre\u0163oiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082079599","display_name":"Sanda Maria Cre\u0163oiu","orcid":"https://orcid.org/0000-0003-2575-4880","observed_orcids":["https://orcid.org/0000-0003-2575-4880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanda Cre\u0163oiu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112607021","display_name":"Ana Petri\u015for","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Petri\u015for","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076091091","display_name":"Radu Usvat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Usvat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006527196","display_name":"Daniela Adriana Ion","orcid":"https://orcid.org/0000-0003-1031-7557","observed_orcids":["https://orcid.org/0000-0003-1031-7557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Adriana Ion","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1355,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.87182057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"50","issue":"3","first_page":"407","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9959999918937683},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9599999785423279},{"id":"https://openalex.org/keywords/gamma-glutamyl-transferase","display_name":"gamma-glutamyl transferase","score":0.9509999752044678},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9589999914169312},{"id":"https://openalex.org/keywords/hcv-genotype-1","display_name":"HCV genotype 1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.9404327869415283},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8177681565284729},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7093369364738464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6999873518943787},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6337229013442993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5894834995269775},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.5508548617362976},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5269095301628113},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.47637197375297546},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.45761531591415405},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4270690679550171},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3840082883834839},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34694764018058777},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1969529092311859},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.16980451345443726}],"mesh":[{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D019698","descriptor_name":"Hepatitis C, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19690766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19690766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie","raw_type":"Journal Article"},{"id":"mag:70965044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19690766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1951557411","https://openalex.org/W1965255263","https://openalex.org/W1972290395","https://openalex.org/W1973978057","https://openalex.org/W1990975397","https://openalex.org/W2009664127","https://openalex.org/W2010094123","https://openalex.org/W2040109162","https://openalex.org/W2043643409","https://openalex.org/W2049065283","https://openalex.org/W2049991841","https://openalex.org/W2072683805","https://openalex.org/W2075145016","https://openalex.org/W2084291231","https://openalex.org/W2087829753","https://openalex.org/W2088767361","https://openalex.org/W2094174828","https://openalex.org/W2110267763","https://openalex.org/W2116404316","https://openalex.org/W2127249598","https://openalex.org/W2132290252","https://openalex.org/W2133053216","https://openalex.org/W2160832007"],"related_works":["https://openalex.org/W2068437958","https://openalex.org/W2411737044","https://openalex.org/W2046532604","https://openalex.org/W2145220674","https://openalex.org/W2092230718","https://openalex.org/W2097815979","https://openalex.org/W2080468761","https://openalex.org/W2125154207","https://openalex.org/W2073625464","https://openalex.org/W2092600263"],"abstract_inverted_index":{"UNLABELLED:":[0],"Oxidative":[1],"stress":[2,90,204,220],"is":[3,16,148,231],"an":[4,164,232],"important":[5],"pathophysiological":[6],"mechanism":[7],"in":[8,19,63,126,142,187,212,247],"chronic":[9,68,127],"hepatitis":[10,69,128],"with":[11,35,67,76,82,129,138,163,169,174,189,192],"C-virus":[12,130],"infection":[13],"(CHC).":[14],"Steatosis":[15],"frequently":[17],"observed":[18],"CHC":[20],"and":[21,61,73,91,112,135,172,205,218,221,242],"seems":[22],"to":[23,37,47,209],"have":[24],"a":[25,143,175],"significant":[26],"impact":[27],"on":[28],"the":[29,33,49,77,120,136,223,248,251],"natural":[30],"history":[31],"of":[32,39,43,54,122,145,166,177,181,225,229,250],"disease":[34],"respect":[36],"development":[38],"fibrosis.":[40,226],"The":[41,179,227],"aim":[42],"this":[44],"study":[45],"was":[46,133,141,161,184],"investigate":[48],"relationship":[50],"between":[51],"systemic":[52],"parameters":[53],"oxidative":[55,89,203,219,236],"stress,":[56],"insulin":[57,123,206,216],"resistance,":[58],"steatosis":[59,140,160],"degree,":[60],"fibrosis":[62],"CHC.":[64],"Fifty":[65],"patients":[66,188,197],"C":[70],"(29":[71],"men":[72],"21":[74],"women":[75],"average":[78],"age":[79],"45":[80],"years),":[81],"or":[83],"without":[84],"steatosis,":[85,190,210],"were":[86],"tested":[87],"for:":[88],"antioxidant":[92],"status":[93],"by":[94,150,199,239],"measuring":[95],"serum":[96,182],"malondialdehyde":[97],"(MDA),":[98],"total":[99],"blood":[100],"non-proteic":[101],"thiols":[102],"concentration":[103],"(GSH),":[104],"gamma":[105],"glutamyl":[106],"transpeptidase":[107],"(GGT)":[108],"activity,":[109],"lipid":[110,240],"parameters,":[111],"liver":[113],"function":[114],"tests.":[115],"Our":[116],"results":[117],"show":[118],"that":[119],"prevalence":[121],"resistance":[124,207,217],"(IR)":[125],"genotype":[131,201],"1":[132],"32%":[134],"association":[137],"hepatic":[139],"proportion":[144],"48%,":[146],"IR":[147],"mediated":[149],"both":[151,215],"metabolic":[152],"factors":[153],"as":[154,156],"well":[155],"viral":[157],"factors.":[158],"Hepatic":[159],"associated":[162],"increase":[165],"MDA,":[167],"correlated":[168],"its":[170,193],"severity,":[171],"secondary":[173],"decrease":[176],"GSH.":[178],"activity":[180],"GGT":[183,230],"net":[185],"superior,":[186],"proportional":[191],"degree.":[194],"CONCLUSIONS:":[195],"In":[196],"infected":[198],"HCV":[200],"1,":[202],"contribute":[208],"which":[211],"turn":[213],"exacerbates":[214],"accelerates":[222],"progression":[224,249],"induction":[228],"adaptive":[233],"response":[234],"against":[235],"damage":[237],"elicited":[238],"peroxidation":[241],"it":[243],"may":[244],"be":[245],"critical":[246],"disease.":[252]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}