{"id":"https://openalex.org/W7096417596","doi":null,"title":"Mitochondrial Function and Insulin Resistance during Aging - A Mini-Review.\" Gerontology57(5","display_name":"Mitochondrial Function and Insulin Resistance during Aging - A Mini-Review.\" Gerontology57(5","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W7096417596"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.603.9856","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.603.9856","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://care.diabetesjournals.org/content/32/4/677.full.pdf","raw_type":"text"},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Julia Szendroedi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Szendroedi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006954462","display_name":"Martin Meyerspeer","orcid":"https://orcid.org/0000-0002-0295-8218","observed_orcids":["https://orcid.org/0000-0002-0295-8218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Meyerspeer Phd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111554971","display_name":"Camilla Cervin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla Cervin Phd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049615554","display_name":"Michaela Kacerovsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Kacerovsky Md","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008911473","display_name":"Gerhard Smekal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerhard Smekal Md","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005715811","display_name":"S Gr\u00e4ser-Lang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Gra\u0308ser-lang Md","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Leif Groop","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leif Groop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Michael Roden Md","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Roden Md","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01716528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.7820000052452087},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8090000152587891},{"id":"https://openalex.org/keywords/melas","display_name":"MELAS","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.75},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.796999990940094},{"id":"https://openalex.org/keywords/skeletal-muscle-mitochondria","display_name":"skeletal muscle mitochondria","score":0.703000009059906},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.7929999828338623},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8149999976158142},{"id":"https://openalex.org/keywords/endogenous-glucose-production","display_name":"endogenous glucose production","score":0.8880000114440918},{"id":"https://openalex.org/keywords/intramyocellular-lipid","display_name":"intramyocellular lipid","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cellular-respiration","display_name":"cellular respiration","score":0.5460000038146973},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7831000089645386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7545999884605408},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7240999937057495},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.593999981880188},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.583299994468689},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5356000065803528},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5277000069618225},{"id":"https://openalex.org/C2775833069","wikidata":"https://www.wikidata.org/wiki/Q6881881","display_name":"Mitochondrial myopathy","level":4,"score":0.4936999976634979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4918000102043152},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.475600004196167},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4690999984741211},{"id":"https://openalex.org/C2780317664","wikidata":"https://www.wikidata.org/wiki/Q1500373","display_name":"Lactic acidosis","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3382999897003174},{"id":"https://openalex.org/C11701378","wikidata":"https://www.wikidata.org/wiki/Q3493378","display_name":"Mitochondrial matrix","level":4,"score":0.30869999527931213},{"id":"https://openalex.org/C2776287708","wikidata":"https://www.wikidata.org/wiki/Q2666433","display_name":"MELAS syndrome","level":5,"score":0.3012999892234802},{"id":"https://openalex.org/C70818257","wikidata":"https://www.wikidata.org/wiki/Q502671","display_name":"Metabolic control analysis","level":3,"score":0.2912999987602234},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.2879999876022339},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.603.9856","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.603.9856","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://care.diabetesjournals.org/content/32/4/677.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099857700","https://openalex.org/W2139467028","https://openalex.org/W1998158504","https://openalex.org/W1971834999","https://openalex.org/W2027670788","https://openalex.org/W2111504946","https://openalex.org/W1973842058","https://openalex.org/W2152958952","https://openalex.org/W1973472671","https://openalex.org/W1968826789"],"abstract_inverted_index":{"OBJECTIVE":[0],"\u2014":[1,35,96,160],"Impaired":[2],"muscular":[3,38],"mitochondrial":[4,39,164,223,232],"function":[5,233],"is":[6,23,198,263],"related":[7],"to":[8,20,26,173,217,222,260],"common":[9],"insulin":[10,60,102,167,261],"resistance":[11,168],"in":[12,44,75,91,178,207],"type":[13],"2":[14],"diabetes.":[15],"Mitochondrial":[16],"diseases":[17],"frequently":[18],"lead":[19],"diabetes,":[21],"which":[22],"mostly":[24],"attributed":[25,216],"defective":[27,208],"-cell":[28],"mitochondria":[29,258],"and":[30,41,49,59,62,86,90,111,119,122,129,134,148,156,169,195,234,242],"secretion.":[31],"RESEARCH":[32],"DESIGN":[33],"ANDMETHODS":[34],"We":[36],"assessed":[37],"func-tion":[40],"lipid":[42],"deposition":[43],"liver":[45,243],"(hepatocellular":[46,245],"lipids":[47,52,238,240,244,246],"[HCLs])":[48,247],"muscle":[50,163,237],"(intramyocellular":[51,239],"[IMCLs])":[53,241],"using":[54,67],"31P/1H":[55],"magnetic":[56],"resonance":[57],"spectroscopy":[58],"sensitivity":[61,103],"en-dogenous":[63],"glucose":[64],"production":[65],"(EGP)":[66],"hyperinsulinemic-euglycemic":[68],"clamps":[69],"combined":[70],"with":[71,141,181],"isotopic":[72],"tracer":[73],"dilution":[74],"one":[76],"female":[77],"patient":[78,99,155],"suffering":[79],"from":[80],"MELAS":[81,98,154,183,190],"(myopathy,":[82,191],"encephalopathy,":[83],"lactic":[84,193],"acidosis,":[85,194],"stroke-like":[87],"episodes)":[88],"syndrome":[89,197],"six":[92],"control":[93,145,157],"subjects.":[94,146,158],"RESULTS":[95],"The":[97,189,249],"showed":[100],"impaired":[101],"(4.3":[104],"vs.":[105,116,131],"8.6":[106],"0.5":[107],"mg":[108],"kg1":[109],"min1)":[110,139],"suppression":[112],"of":[113,143,162,176,225,251,256],"EGP":[114],"(69":[115],"94":[117],"1%),":[118],"her":[120],"baseline":[121],"insulin-stimulated":[123],"ATP":[124],"synthesis":[125],"were":[126,150],"reduced":[127,231],"(7.3":[128],"8.9":[130],"10.6":[132],"1.0":[133],"12.8":[135],"1.3":[136],"mol":[137],"l1":[138],"compared":[140],"those":[142],"the":[144,153,174,182,254],"HCLs":[147],"IMCLs":[149],"comparable":[151],"between":[152],"CONCLUSIONS":[159],"Impairment":[161],"fitness":[165],"promotes":[166],"could":[170],"thereby":[171],"contribute":[172],"development":[175],"diabetes":[177,212],"some":[179],"patients":[180],"syndrome.":[184],"Diabetes":[185],"Care":[186],"32:677\u2013679,":[187],"2009":[188],"encephalop-athy,":[192],"stroke-likeepisodes)":[196],"caused":[199],"by":[200],"a":[201],"maternally":[202],"inherited":[203],"mtDNA":[204],"mutation,":[205],"resulting":[206],"cellular":[209],"respiration.":[210],"MELAS-associated":[211],"has":[213],"been":[214],"primarily":[215],"insufficient":[218],"insu-lin":[219],"secretion":[220],"due":[221],"dys-function":[224],"pancreatic":[226],"-cells.":[227],"Insulin-resistant":[228],"populations":[229],"show":[230],"increased":[235],"so-leus":[236],"(1).":[248],"sequence":[250],"events,":[252],"particularly":[253],"possibility":[255],"mus-cle":[257],"leading":[259],"resis-tance,":[262],"unclear.":[264]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-27T00:00:00"}
