{"id":"https://openalex.org/W7096099247","doi":null,"title":"RA. Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study. Circulation","display_name":"RA. Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study. Circulation","publication_year":2016,"publication_date":"2016-10-11","ids":{"openalex":"https://openalex.org/W7096099247"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.981.9657","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.981.9657","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/116/11_suppl/I-288.full.pdf","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020092566","display_name":"R\u043enen Beeri","orcid":"https://orcid.org/0000-0002-8014-0702","observed_orcids":["https://orcid.org/0000-0002-8014-0702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronen Beeri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5054227809","display_name":"Mark D. Handschumacher","orcid":"https://orcid.org/0000-0002-9214-9544","observed_orcids":["https://orcid.org/0000-0002-9214-9544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark D. Handschumacher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.50628515,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":true,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12598","display_name":"Cardiac Structural Anomalies and Repair","score":0.2069000005722046,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-mitral-regurgitation","display_name":"ischemic mitral regurgitation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mitral-valve-repair","display_name":"mitral valve repair","score":0.8479999899864197},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.9539999961853027},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9350000023841858},{"id":"https://openalex.org/keywords/sheep-model","display_name":"sheep model","score":0.5870000123977661},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.7730000019073486},{"id":"https://openalex.org/keywords/p-akt","display_name":"pAKT","score":0.8510000109672546},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/timp-4","display_name":"TIMP-4","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ventricular-contractility","display_name":"ventricular contractility","score":0.6690000295639038},{"id":"https://openalex.org/keywords/post-infarction-remodeling","display_name":"post-infarction remodeling","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8622000217437744},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7878000140190125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7687000036239624},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.6944000124931335},{"id":"https://openalex.org/C2780968331","wikidata":"https://www.wikidata.org/wiki/Q1890115","display_name":"Shunt (medical)","level":2,"score":0.5491999983787537},{"id":"https://openalex.org/C2909944400","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Functional mitral regurgitation","level":4,"score":0.504800021648407},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.4925999939441681},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.4300999939441681},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.41589999198913574},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.3944000005722046},{"id":"https://openalex.org/C179437574","wikidata":"https://www.wikidata.org/wiki/Q15089798","display_name":"Ligation","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C21143770","wikidata":"https://www.wikidata.org/wiki/Q3366819","display_name":"End-diastolic volume","level":5,"score":0.3767000138759613},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.36579999327659607},{"id":"https://openalex.org/C24595384","wikidata":"https://www.wikidata.org/wiki/Q17143767","display_name":"Volume overload","level":3,"score":0.3605000078678131},{"id":"https://openalex.org/C2775961468","wikidata":"https://www.wikidata.org/wiki/Q7487374","display_name":"Sham surgery","level":3,"score":0.35589998960494995},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.3495999872684479},{"id":"https://openalex.org/C2779745306","wikidata":"https://www.wikidata.org/wiki/Q616087","display_name":"Aortic valve regurgitation","level":3,"score":0.3395000100135803},{"id":"https://openalex.org/C2780679668","wikidata":"https://www.wikidata.org/wiki/Q6882374","display_name":"Mitral valve repair","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C2780168065","wikidata":"https://www.wikidata.org/wiki/Q1930043","display_name":"Regurgitation (circulation)","level":2,"score":0.2854999899864197},{"id":"https://openalex.org/C65882447","wikidata":"https://www.wikidata.org/wiki/Q5375773","display_name":"End-systolic volume","level":5,"score":0.2757999897003174},{"id":"https://openalex.org/C48277249","wikidata":"https://www.wikidata.org/wiki/Q1406926","display_name":"Preload","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C2776268601","wikidata":"https://www.wikidata.org/wiki/Q968808","display_name":"Occlusion","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.981.9657","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.981.9657","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/circulationaha/116/11_suppl/I-288.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018338899","https://openalex.org/W2046593402","https://openalex.org/W2049641081","https://openalex.org/W1207272333","https://openalex.org/W4251420343","https://openalex.org/W7163680037","https://openalex.org/W1974729166","https://openalex.org/W2163740518","https://openalex.org/W3213639030","https://openalex.org/W7132282228"],"abstract_inverted_index":{"Background\u2014Mitral":[0],"regurgitation":[1],"(MR)":[2],"doubles":[3],"postmyocardial":[4],"infarction":[5],"(MI)":[6],"mortality.":[7],"We":[8,31],"have":[9],"shown":[10],"that":[11,33,194],"moderate":[12,35,216],"MR":[13,36,217],"augments":[14],"remodeling":[15,112,229],"in":[16,50,60,88,149,197,218],"an":[17],"apical":[18,222],"MI":[19,40,184,223],"model":[20],"(no":[21],"intrinsic":[22],"MR)":[23],"with":[24,116,181,231],"independent":[25],"left":[26,55,102,233],"ventricle-to-left":[27,56],"atrial":[28,57],"MR-type":[29],"flow.":[30],"hypothesized":[32],"repairing":[34],"1":[37,72,83],"month":[38,73,99],"after":[39],"reverses":[41,225],"this":[42],"remodeling.":[43],"Methods":[44],"and":[45,53,81,84,92,120,124,132,142,152,164,199,205],"Results\u2014Anteroapical":[46],"MIs":[47],"were":[48,77,146],"created":[49],"18":[51],"sheep,":[52],"a":[54],"shunt":[58,69,109],"implanted":[59],"12":[61],"(regurgitant":[62],"fraction,":[63],"30%).":[64],"Six":[65],"sheep":[66],"had":[67],"the":[68,89,97,150,206,219,226],"closed":[70],"at":[71,79,82,113,178,202],"(repair":[74],"group).":[75],"Sheep":[76,87],"compared":[78],"baseline,":[80],"3":[85,114,139,179,203],"months.":[86],"MIMR":[90],"(unrepaired)":[91],"repaired":[93,151],"groups":[94,154],"remodeled":[95],"during":[96],"first":[98],"(120%":[100],"increased":[101,167,211],"ventricular":[103,234],"end-systolic":[104],"volume":[105,118],"[ESV;":[106],"P0.01]),":[107],"but":[108,175],"closure":[110],"reversed":[111],"months,":[115,140,204],"end-diastolic":[117],"(EDV)":[119],"ESV":[121],"135":[122],"%":[123,126,131,134,158,193],"128":[125],"of":[127,215,221],"baseline":[128,172],"versus":[129,155],"220":[130],"280":[133],"without":[135,160,173,195],"repair":[136,182,196,214],"(P0.001).":[137],"At":[138],"dP/dt":[141],"preload-recruitable":[143],"stroke":[144],"work":[145],"relatively":[147,236],"maintained":[148,237],"MI-only":[153],"nearly":[156],"50":[157,192],"decreases":[159],"repair.":[161],"Prohypertrophic":[162],"gp130":[163],"antiapoptotic":[165],"pAkt":[166],"followed":[168],"by":[169],"exhaustion":[170],"below":[171],"repair,":[174,187],"remained":[176],"elevated":[177],"months":[180],"or":[183],"only.":[185],"With":[186],"matrix":[188,207],"metalloproteinase-2":[189],"decreased":[190],"to":[191],"remote":[198],"border":[200],"zones":[201],"metalloproteinase":[208],"inhibitor":[209],"TIMP-4":[210],"dramatically.":[212],"Conclusions\u2014Early":[213],"setting":[220],"substantially":[224],"otherwise":[227],"progressive":[228],"process,":[230],"reduced":[232],"volumes,":[235],"contractility,":[238],"persistently":[239],"activated":[240]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-27T00:00:00"}